SIRPA-IL15 HUMANIZED SIRPA-IL15 KNOCKIN MICE AND METHODS OF USE THEREOF
비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 유전자 변형된 비-인간 동물이 제공된다. 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 비-인간 동물의 제조 방법, 및 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 비-인간 동물의 이용 방법이 또한 제공된다. 이들 동물 및 방법은, 예를 들어, 인간 T 세포 및/또는 자연 살해 (NK) 세포 발생 및 기능의 모델링, 인간 T 세포 및/또는 NK 세포의 인간 병원체 감염 모델링, 및 다양한 생체내 스크린을 포함한...
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| creator | HERNDLER BRANDSTETTER DIETMAR PALM NOAH W FRLETA DAVOR STEVENS SEAN MANZ MARKUS GABRIEL MURPHY ANDREW J YANCOPOULOS GEORGE D DE ZOETE MARCEL STROWIG TILL FLAVELL RICHARD A GURER CAGAN SHAN LIANG |
| description | 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 유전자 변형된 비-인간 동물이 제공된다. 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 비-인간 동물의 제조 방법, 및 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 비-인간 동물의 이용 방법이 또한 제공된다. 이들 동물 및 방법은, 예를 들어, 인간 T 세포 및/또는 자연 살해 (NK) 세포 발생 및 기능의 모델링, 인간 T 세포 및/또는 NK 세포의 인간 병원체 감염 모델링, 및 다양한 생체내 스크린을 포함한, 당해 기술에서 많은 용도를 찾아낸다.
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens. |
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Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.</description><language>eng ; kor</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; CARE OF BIRDS, FISHES, INSECTS ; CHEMISTRY ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NEW BREEDS OF ANIMALS ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR ; TRAPPING</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240508&DB=EPODOC&CC=KR&NR=20240060648A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240508&DB=EPODOC&CC=KR&NR=20240060648A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HERNDLER BRANDSTETTER DIETMAR</creatorcontrib><creatorcontrib>PALM NOAH W</creatorcontrib><creatorcontrib>FRLETA DAVOR</creatorcontrib><creatorcontrib>STEVENS SEAN</creatorcontrib><creatorcontrib>MANZ MARKUS GABRIEL</creatorcontrib><creatorcontrib>MURPHY ANDREW J</creatorcontrib><creatorcontrib>YANCOPOULOS GEORGE D</creatorcontrib><creatorcontrib>DE ZOETE MARCEL</creatorcontrib><creatorcontrib>STROWIG TILL</creatorcontrib><creatorcontrib>FLAVELL RICHARD A</creatorcontrib><creatorcontrib>GURER CAGAN</creatorcontrib><creatorcontrib>SHAN LIANG</creatorcontrib><title>SIRPA-IL15 HUMANIZED SIRPA-IL15 KNOCKIN MICE AND METHODS OF USE THEREOF</title><description>비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 유전자 변형된 비-인간 동물이 제공된다. 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 비-인간 동물의 제조 방법, 및 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 비-인간 동물의 이용 방법이 또한 제공된다. 이들 동물 및 방법은, 예를 들어, 인간 T 세포 및/또는 자연 살해 (NK) 세포 발생 및 기능의 모델링, 인간 T 세포 및/또는 NK 세포의 인간 병원체 감염 모델링, 및 다양한 생체내 스크린을 포함한, 당해 기술에서 많은 용도를 찾아낸다.
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>CARE OF BIRDS, FISHES, INSECTS</subject><subject>CHEMISTRY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NEW BREEDS OF ANIMALS</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</subject><subject>TRAPPING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAP9gwKcNT19DE0VfAI9XX084xydVFAEvT283f29vRT8PV0dlVw9HNR8HUN8fB3CVbwd1MIDXZVCPFwDXL1d-NhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHeQUYGRiYGBmYGZiYWjsbEqQIAMu8svg</recordid><startdate>20240508</startdate><enddate>20240508</enddate><creator>HERNDLER BRANDSTETTER DIETMAR</creator><creator>PALM NOAH W</creator><creator>FRLETA DAVOR</creator><creator>STEVENS SEAN</creator><creator>MANZ MARKUS GABRIEL</creator><creator>MURPHY ANDREW J</creator><creator>YANCOPOULOS GEORGE D</creator><creator>DE ZOETE MARCEL</creator><creator>STROWIG TILL</creator><creator>FLAVELL RICHARD A</creator><creator>GURER CAGAN</creator><creator>SHAN LIANG</creator><scope>EVB</scope></search><sort><creationdate>20240508</creationdate><title>SIRPA-IL15 HUMANIZED SIRPA-IL15 KNOCKIN MICE AND METHODS OF USE THEREOF</title><author>HERNDLER BRANDSTETTER DIETMAR ; PALM NOAH W ; FRLETA DAVOR ; STEVENS SEAN ; MANZ MARKUS GABRIEL ; MURPHY ANDREW J ; YANCOPOULOS GEORGE D ; DE ZOETE MARCEL ; STROWIG TILL ; FLAVELL RICHARD A ; GURER CAGAN ; SHAN LIANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20240060648A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2024</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>CARE OF BIRDS, FISHES, INSECTS</topic><topic>CHEMISTRY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NEW BREEDS OF ANIMALS</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</topic><topic>TRAPPING</topic><toplevel>online_resources</toplevel><creatorcontrib>HERNDLER BRANDSTETTER DIETMAR</creatorcontrib><creatorcontrib>PALM NOAH W</creatorcontrib><creatorcontrib>FRLETA DAVOR</creatorcontrib><creatorcontrib>STEVENS SEAN</creatorcontrib><creatorcontrib>MANZ MARKUS GABRIEL</creatorcontrib><creatorcontrib>MURPHY ANDREW J</creatorcontrib><creatorcontrib>YANCOPOULOS GEORGE D</creatorcontrib><creatorcontrib>DE ZOETE MARCEL</creatorcontrib><creatorcontrib>STROWIG TILL</creatorcontrib><creatorcontrib>FLAVELL RICHARD A</creatorcontrib><creatorcontrib>GURER CAGAN</creatorcontrib><creatorcontrib>SHAN LIANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HERNDLER BRANDSTETTER DIETMAR</au><au>PALM NOAH W</au><au>FRLETA DAVOR</au><au>STEVENS SEAN</au><au>MANZ MARKUS GABRIEL</au><au>MURPHY ANDREW J</au><au>YANCOPOULOS GEORGE D</au><au>DE ZOETE MARCEL</au><au>STROWIG TILL</au><au>FLAVELL RICHARD A</au><au>GURER CAGAN</au><au>SHAN LIANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SIRPA-IL15 HUMANIZED SIRPA-IL15 KNOCKIN MICE AND METHODS OF USE THEREOF</title><date>2024-05-08</date><risdate>2024</risdate><abstract>비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 유전자 변형된 비-인간 동물이 제공된다. 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 비-인간 동물의 제조 방법, 및 비-인간 동물 게놈으로부터 인간 SIRPα 및 인간 IL-15를 발현한 비-인간 동물의 이용 방법이 또한 제공된다. 이들 동물 및 방법은, 예를 들어, 인간 T 세포 및/또는 자연 살해 (NK) 세포 발생 및 기능의 모델링, 인간 T 세포 및/또는 NK 세포의 인간 병원체 감염 모델링, 및 다양한 생체내 스크린을 포함한, 당해 기술에서 많은 용도를 찾아낸다.
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR TRAPPING |
| title | SIRPA-IL15 HUMANIZED SIRPA-IL15 KNOCKIN MICE AND METHODS OF USE THEREOF |
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