Novel indazole derivatives or its pharmaceutically acceptable salts and use thereof
본 발명은 인다졸(indazole) 유도체 또는 이의 약학적으로 허용가능한 염, 및 상기 유도체 또는 이의 염을 유효성분으로 포함하는 암 예방, 치료, 또는 개선용 조성물 등에 관한 것으로서, 본 발명의 인다졸 유도체는 Hsp90의 C-terminal domain과 강력한 결합을 부여하도록 설계된 것으로 Hsp90과 HSF-1의 복합체 구조에 영향을 미치지 않으므로 HSF-1의 활성화나 Hsp 유전자들의 발현을 유도하지 않아 효과적으로 암세포의 사멸을 촉진하므로, 암의 예방, 치료, 또는 개선에 활용될 수 있다. The presen...
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| creator | SEO JAE HONG PARK MIN SU KIM YOON JAE PARK SO EUN KO DONG MI LEE JEE WOO HOANG VAN HAI LA MINH THANH KIM JI YOUNG KIM SEONG JAE ANN JI HYAE SEO JU YEON |
| description | 본 발명은 인다졸(indazole) 유도체 또는 이의 약학적으로 허용가능한 염, 및 상기 유도체 또는 이의 염을 유효성분으로 포함하는 암 예방, 치료, 또는 개선용 조성물 등에 관한 것으로서, 본 발명의 인다졸 유도체는 Hsp90의 C-terminal domain과 강력한 결합을 부여하도록 설계된 것으로 Hsp90과 HSF-1의 복합체 구조에 영향을 미치지 않으므로 HSF-1의 활성화나 Hsp 유전자들의 발현을 유도하지 않아 효과적으로 암세포의 사멸을 촉진하므로, 암의 예방, 치료, 또는 개선에 활용될 수 있다.
The present invention relates to an indazole derivative or a pharmaceutically acceptable salt thereof, and a composition for preventing, treating, or ameliorating cancer, comprising, as an active ingredient, the derivative or a pharmaceutically acceptable salt thereof. The indazole derivative of the present invention is designed to provide strong binding to the C-terminal domain of Hsp90, and does not affect the composite structure of Hsp90 and HSF-1, thus not inducing the activation of HSF-1 or the expression of Hsp genes, thereby effectively promoting apoptosis of cancer cells. Thus, the indazole derivative of the present invention can be used in the prevention, treatment, or amelioration of cancer. |
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The present invention relates to an indazole derivative or a pharmaceutically acceptable salt thereof, and a composition for preventing, treating, or ameliorating cancer, comprising, as an active ingredient, the derivative or a pharmaceutically acceptable salt thereof. The indazole derivative of the present invention is designed to provide strong binding to the C-terminal domain of Hsp90, and does not affect the composite structure of Hsp90 and HSF-1, thus not inducing the activation of HSF-1 or the expression of Hsp genes, thereby effectively promoting apoptosis of cancer cells. Thus, the indazole derivative of the present invention can be used in the prevention, treatment, or amelioration of cancer.</description><language>eng ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240419&DB=EPODOC&CC=KR&NR=20240050921A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240419&DB=EPODOC&CC=KR&NR=20240050921A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SEO JAE HONG</creatorcontrib><creatorcontrib>PARK MIN SU</creatorcontrib><creatorcontrib>KIM YOON JAE</creatorcontrib><creatorcontrib>PARK SO EUN</creatorcontrib><creatorcontrib>KO DONG MI</creatorcontrib><creatorcontrib>LEE JEE WOO</creatorcontrib><creatorcontrib>HOANG VAN HAI</creatorcontrib><creatorcontrib>LA MINH THANH</creatorcontrib><creatorcontrib>KIM JI YOUNG</creatorcontrib><creatorcontrib>KIM SEONG JAE</creatorcontrib><creatorcontrib>ANN JI HYAE</creatorcontrib><creatorcontrib>SEO JU YEON</creatorcontrib><title>Novel indazole derivatives or its pharmaceutically acceptable salts and use thereof</title><description>본 발명은 인다졸(indazole) 유도체 또는 이의 약학적으로 허용가능한 염, 및 상기 유도체 또는 이의 염을 유효성분으로 포함하는 암 예방, 치료, 또는 개선용 조성물 등에 관한 것으로서, 본 발명의 인다졸 유도체는 Hsp90의 C-terminal domain과 강력한 결합을 부여하도록 설계된 것으로 Hsp90과 HSF-1의 복합체 구조에 영향을 미치지 않으므로 HSF-1의 활성화나 Hsp 유전자들의 발현을 유도하지 않아 효과적으로 암세포의 사멸을 촉진하므로, 암의 예방, 치료, 또는 개선에 활용될 수 있다.
The present invention relates to an indazole derivative or a pharmaceutically acceptable salt thereof, and a composition for preventing, treating, or ameliorating cancer, comprising, as an active ingredient, the derivative or a pharmaceutically acceptable salt thereof. The indazole derivative of the present invention is designed to provide strong binding to the C-terminal domain of Hsp90, and does not affect the composite structure of Hsp90 and HSF-1, thus not inducing the activation of HSF-1 or the expression of Hsp genes, thereby effectively promoting apoptosis of cancer cells. Thus, the indazole derivative of the present invention can be used in the prevention, treatment, or amelioration of cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzLEKwjAURuEsDqK-wwVnIUYdOoooguCg7uWa_qWBmIQkDejTm8EHcDrLx5mK-9UXWDKu44-3oA7RFM6mIJGPZHKiMHB8scaYjWZr38RaI2R-Vp7YVsGuozGB8oAI38_FpGebsPh1Jpan4-NwXiH4FinUl0NuLzcl1VbKnWzUer_5T30BgAU5uQ</recordid><startdate>20240419</startdate><enddate>20240419</enddate><creator>SEO JAE HONG</creator><creator>PARK MIN SU</creator><creator>KIM YOON JAE</creator><creator>PARK SO EUN</creator><creator>KO DONG MI</creator><creator>LEE JEE WOO</creator><creator>HOANG VAN HAI</creator><creator>LA MINH THANH</creator><creator>KIM JI YOUNG</creator><creator>KIM SEONG JAE</creator><creator>ANN JI HYAE</creator><creator>SEO JU YEON</creator><scope>EVB</scope></search><sort><creationdate>20240419</creationdate><title>Novel indazole derivatives or its pharmaceutically acceptable salts and use thereof</title><author>SEO JAE HONG ; PARK MIN SU ; KIM YOON JAE ; PARK SO EUN ; KO DONG MI ; LEE JEE WOO ; HOANG VAN HAI ; LA MINH THANH ; KIM JI YOUNG ; KIM SEONG JAE ; ANN JI HYAE ; SEO JU YEON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20240050921A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SEO JAE HONG</creatorcontrib><creatorcontrib>PARK MIN SU</creatorcontrib><creatorcontrib>KIM YOON JAE</creatorcontrib><creatorcontrib>PARK SO EUN</creatorcontrib><creatorcontrib>KO DONG MI</creatorcontrib><creatorcontrib>LEE JEE WOO</creatorcontrib><creatorcontrib>HOANG VAN HAI</creatorcontrib><creatorcontrib>LA MINH THANH</creatorcontrib><creatorcontrib>KIM JI YOUNG</creatorcontrib><creatorcontrib>KIM SEONG JAE</creatorcontrib><creatorcontrib>ANN JI HYAE</creatorcontrib><creatorcontrib>SEO JU YEON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SEO JAE HONG</au><au>PARK MIN SU</au><au>KIM YOON JAE</au><au>PARK SO EUN</au><au>KO DONG MI</au><au>LEE JEE WOO</au><au>HOANG VAN HAI</au><au>LA MINH THANH</au><au>KIM JI YOUNG</au><au>KIM SEONG JAE</au><au>ANN JI HYAE</au><au>SEO JU YEON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Novel indazole derivatives or its pharmaceutically acceptable salts and use thereof</title><date>2024-04-19</date><risdate>2024</risdate><abstract>본 발명은 인다졸(indazole) 유도체 또는 이의 약학적으로 허용가능한 염, 및 상기 유도체 또는 이의 염을 유효성분으로 포함하는 암 예방, 치료, 또는 개선용 조성물 등에 관한 것으로서, 본 발명의 인다졸 유도체는 Hsp90의 C-terminal domain과 강력한 결합을 부여하도록 설계된 것으로 Hsp90과 HSF-1의 복합체 구조에 영향을 미치지 않으므로 HSF-1의 활성화나 Hsp 유전자들의 발현을 유도하지 않아 효과적으로 암세포의 사멸을 촉진하므로, 암의 예방, 치료, 또는 개선에 활용될 수 있다.
The present invention relates to an indazole derivative or a pharmaceutically acceptable salt thereof, and a composition for preventing, treating, or ameliorating cancer, comprising, as an active ingredient, the derivative or a pharmaceutically acceptable salt thereof. The indazole derivative of the present invention is designed to provide strong binding to the C-terminal domain of Hsp90, and does not affect the composite structure of Hsp90 and HSF-1, thus not inducing the activation of HSF-1 or the expression of Hsp genes, thereby effectively promoting apoptosis of cancer cells. Thus, the indazole derivative of the present invention can be used in the prevention, treatment, or amelioration of cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Novel indazole derivatives or its pharmaceutically acceptable salts and use thereof |
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