A fusion protein comprising an antigen binding domain and a cytokine trimer domain
The present invention relates to a new type of fusion protein (RACE (receptor-antibody conjugated (cell) engager)) combining antibodies and cytokine trimeric domains, wherein the fusion protein includes a cytokine trimeric domain in which a dimer of a first monomer and a second monomer connected by...
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| creator | SON KKA BI BAK JEONG HYEON LEE DAE HEE JANG SE IL |
| description | The present invention relates to a new type of fusion protein (RACE (receptor-antibody conjugated (cell) engager)) combining antibodies and cytokine trimeric domains, wherein the fusion protein includes a cytokine trimeric domain in which a dimer of a first monomer and a second monomer connected by a linker and a third monomer are coupled by a knob-into-hole, and the fusion protein is prepared by replacing a constant region (Fc) of an antibody with the cytokine trimeric domain. It has been confirmed that RACE according to the present invention not only exhibits superior binding ability to a target receptor than a parent antibody, but also exhibits excellent simultaneous binding ability to an antigen and the target receptor, and thus can be usefully used as a bispecific pharmaceutical composition. The fusion protein includes an antigen-binding domain and a cytokine trimeric domain.
본 발명은 링커로 연결된 제 1 단량체 및 제 2 단량체(dimer)와 제 3 단량체(monomer)가 노브-인투-홀에 의해 결합된 사이토카인 삼량체 도메인 및 항체의 불변 영역(Fc)를 상기 사이토카인 삼량체 도메인으로 대체하여 제조한, 항체 및 사이토카인 삼량체 도메인이 결합된 새로운 형태의 융합 단백질(RACE(Receptor-Antibody Conjugated (cell) Engager))에 대한 것으로, 본 발명에 따른 RACE는 타겟 수용체에 대해 모항체보다 우수한 결합능을 보일 뿐만 아니라 항원 및 타겟 수용체에 대해 우수한 동시 결합능을 보임을 확인한 바, 이를 이중특이성 약학적 조성물로 유용하게 활용할 수 있다. |
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본 발명은 링커로 연결된 제 1 단량체 및 제 2 단량체(dimer)와 제 3 단량체(monomer)가 노브-인투-홀에 의해 결합된 사이토카인 삼량체 도메인 및 항체의 불변 영역(Fc)를 상기 사이토카인 삼량체 도메인으로 대체하여 제조한, 항체 및 사이토카인 삼량체 도메인이 결합된 새로운 형태의 융합 단백질(RACE(Receptor-Antibody Conjugated (cell) Engager))에 대한 것으로, 본 발명에 따른 RACE는 타겟 수용체에 대해 모항체보다 우수한 결합능을 보일 뿐만 아니라 항원 및 타겟 수용체에 대해 우수한 동시 결합능을 보임을 확인한 바, 이를 이중특이성 약학적 조성물로 유용하게 활용할 수 있다.</description><language>eng ; kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230829&DB=EPODOC&CC=KR&NR=20230125696A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230829&DB=EPODOC&CC=KR&NR=20230125696A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SON KKA BI</creatorcontrib><creatorcontrib>BAK JEONG HYEON</creatorcontrib><creatorcontrib>LEE DAE HEE</creatorcontrib><creatorcontrib>JANG SE IL</creatorcontrib><title>A fusion protein comprising an antigen binding domain and a cytokine trimer domain</title><description>The present invention relates to a new type of fusion protein (RACE (receptor-antibody conjugated (cell) engager)) combining antibodies and cytokine trimeric domains, wherein the fusion protein includes a cytokine trimeric domain in which a dimer of a first monomer and a second monomer connected by a linker and a third monomer are coupled by a knob-into-hole, and the fusion protein is prepared by replacing a constant region (Fc) of an antibody with the cytokine trimeric domain. It has been confirmed that RACE according to the present invention not only exhibits superior binding ability to a target receptor than a parent antibody, but also exhibits excellent simultaneous binding ability to an antigen and the target receptor, and thus can be usefully used as a bispecific pharmaceutical composition. The fusion protein includes an antigen-binding domain and a cytokine trimeric domain.
본 발명은 링커로 연결된 제 1 단량체 및 제 2 단량체(dimer)와 제 3 단량체(monomer)가 노브-인투-홀에 의해 결합된 사이토카인 삼량체 도메인 및 항체의 불변 영역(Fc)를 상기 사이토카인 삼량체 도메인으로 대체하여 제조한, 항체 및 사이토카인 삼량체 도메인이 결합된 새로운 형태의 융합 단백질(RACE(Receptor-Antibody Conjugated (cell) Engager))에 대한 것으로, 본 발명에 따른 RACE는 타겟 수용체에 대해 모항체보다 우수한 결합능을 보일 뿐만 아니라 항원 및 타겟 수용체에 대해 우수한 동시 결합능을 보임을 확인한 바, 이를 이중특이성 약학적 조성물로 유용하게 활용할 수 있다.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAhyVEgrLc7Mz1MoKMovSc3MU0jOzy0oyizOzEtXSMwDopLM9NQ8haTMvBSQUEp-bmImSDhFIVEhubIkPzszL1WhpCgzN7UIKsnDwJqWmFOcyguluRmU3VxDnD10Uwvy41OLCxKTU_NSS-K9g4wMjIwNDI1MzSzNHI2JUwUA2Nc4uw</recordid><startdate>20230829</startdate><enddate>20230829</enddate><creator>SON KKA BI</creator><creator>BAK JEONG HYEON</creator><creator>LEE DAE HEE</creator><creator>JANG SE IL</creator><scope>EVB</scope></search><sort><creationdate>20230829</creationdate><title>A fusion protein comprising an antigen binding domain and a cytokine trimer domain</title><author>SON KKA BI ; BAK JEONG HYEON ; LEE DAE HEE ; JANG SE IL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20230125696A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SON KKA BI</creatorcontrib><creatorcontrib>BAK JEONG HYEON</creatorcontrib><creatorcontrib>LEE DAE HEE</creatorcontrib><creatorcontrib>JANG SE IL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SON KKA BI</au><au>BAK JEONG HYEON</au><au>LEE DAE HEE</au><au>JANG SE IL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A fusion protein comprising an antigen binding domain and a cytokine trimer domain</title><date>2023-08-29</date><risdate>2023</risdate><abstract>The present invention relates to a new type of fusion protein (RACE (receptor-antibody conjugated (cell) engager)) combining antibodies and cytokine trimeric domains, wherein the fusion protein includes a cytokine trimeric domain in which a dimer of a first monomer and a second monomer connected by a linker and a third monomer are coupled by a knob-into-hole, and the fusion protein is prepared by replacing a constant region (Fc) of an antibody with the cytokine trimeric domain. It has been confirmed that RACE according to the present invention not only exhibits superior binding ability to a target receptor than a parent antibody, but also exhibits excellent simultaneous binding ability to an antigen and the target receptor, and thus can be usefully used as a bispecific pharmaceutical composition. The fusion protein includes an antigen-binding domain and a cytokine trimeric domain.
본 발명은 링커로 연결된 제 1 단량체 및 제 2 단량체(dimer)와 제 3 단량체(monomer)가 노브-인투-홀에 의해 결합된 사이토카인 삼량체 도메인 및 항체의 불변 영역(Fc)를 상기 사이토카인 삼량체 도메인으로 대체하여 제조한, 항체 및 사이토카인 삼량체 도메인이 결합된 새로운 형태의 융합 단백질(RACE(Receptor-Antibody Conjugated (cell) Engager))에 대한 것으로, 본 발명에 따른 RACE는 타겟 수용체에 대해 모항체보다 우수한 결합능을 보일 뿐만 아니라 항원 및 타겟 수용체에 대해 우수한 동시 결합능을 보임을 확인한 바, 이를 이중특이성 약학적 조성물로 유용하게 활용할 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | A fusion protein comprising an antigen binding domain and a cytokine trimer domain |
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