PURIFICATION OF MULTISPECIFIC ANTIBODIES
본 발명은 다중특이적 항체를 정제하는 방법을 제공한다. 상기 방법은 포획 크로마토그래피, 제1 혼합 방식 크로마토그래피 및 제2 혼합 방식 크로마토그래피를 수행하는 순차 단계를 포함한다. 일부 양태에서, 본 발명은 다중특이적 항체의 조성물을 제공하고, 상기 조성물은 감소된 수준의 하나 이상의 생성물-특이적 불순물 및/또는 공정-특이적 불순물을 갖는다. The present invention provides methods of purifying multispecific antibodies. The methods comprise the...
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| creator | BIALAS AGATHE KOEHNLEIN WOLFGANG KALEAS CARROLL KIMBERLY ANN ROSENBERG EVA YIGZAW YINGES KONRAD SUSANNE WILLMANN STEFFEN GIESE GLEN SCOTT SALLIER BERNARD |
| description | 본 발명은 다중특이적 항체를 정제하는 방법을 제공한다. 상기 방법은 포획 크로마토그래피, 제1 혼합 방식 크로마토그래피 및 제2 혼합 방식 크로마토그래피를 수행하는 순차 단계를 포함한다. 일부 양태에서, 본 발명은 다중특이적 항체의 조성물을 제공하고, 상기 조성물은 감소된 수준의 하나 이상의 생성물-특이적 불순물 및/또는 공정-특이적 불순물을 갖는다.
The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In some aspects, the invention provides compositions of multispecific antibodies, which compositions have reduced levels of one or more product-specific impurities and/or process-specific impurities. |
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The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In some aspects, the invention provides compositions of multispecific antibodies, which compositions have reduced levels of one or more product-specific impurities and/or process-specific impurities.</description><language>eng ; kor</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230731&DB=EPODOC&CC=KR&NR=20230113662A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230731&DB=EPODOC&CC=KR&NR=20230113662A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BIALAS AGATHE</creatorcontrib><creatorcontrib>KOEHNLEIN WOLFGANG</creatorcontrib><creatorcontrib>KALEAS CARROLL KIMBERLY ANN</creatorcontrib><creatorcontrib>ROSENBERG EVA</creatorcontrib><creatorcontrib>YIGZAW YINGES</creatorcontrib><creatorcontrib>KONRAD SUSANNE</creatorcontrib><creatorcontrib>WILLMANN STEFFEN</creatorcontrib><creatorcontrib>GIESE GLEN SCOTT</creatorcontrib><creatorcontrib>SALLIER BERNARD</creatorcontrib><title>PURIFICATION OF MULTISPECIFIC ANTIBODIES</title><description>본 발명은 다중특이적 항체를 정제하는 방법을 제공한다. 상기 방법은 포획 크로마토그래피, 제1 혼합 방식 크로마토그래피 및 제2 혼합 방식 크로마토그래피를 수행하는 순차 단계를 포함한다. 일부 양태에서, 본 발명은 다중특이적 항체의 조성물을 제공하고, 상기 조성물은 감소된 수준의 하나 이상의 생성물-특이적 불순물 및/또는 공정-특이적 불순물을 갖는다.
The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In some aspects, the invention provides compositions of multispecific antibodies, which compositions have reduced levels of one or more product-specific impurities and/or process-specific impurities.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAICA3ydPN0dgzx9PdT8HdT8A31CfEMDnB1BokqOPqFeDr5u3i6BvMwsKYl5hSn8kJpbgZlN9cQZw_d1IL8-NTigsTk1LzUknjvICMDI2MDQ0NjMzMjR2PiVAEArBYlFA</recordid><startdate>20230731</startdate><enddate>20230731</enddate><creator>BIALAS AGATHE</creator><creator>KOEHNLEIN WOLFGANG</creator><creator>KALEAS CARROLL KIMBERLY ANN</creator><creator>ROSENBERG EVA</creator><creator>YIGZAW YINGES</creator><creator>KONRAD SUSANNE</creator><creator>WILLMANN STEFFEN</creator><creator>GIESE GLEN SCOTT</creator><creator>SALLIER BERNARD</creator><scope>EVB</scope></search><sort><creationdate>20230731</creationdate><title>PURIFICATION OF MULTISPECIFIC ANTIBODIES</title><author>BIALAS AGATHE ; KOEHNLEIN WOLFGANG ; KALEAS CARROLL KIMBERLY ANN ; ROSENBERG EVA ; YIGZAW YINGES ; KONRAD SUSANNE ; WILLMANN STEFFEN ; GIESE GLEN SCOTT ; SALLIER BERNARD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20230113662A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>BIALAS AGATHE</creatorcontrib><creatorcontrib>KOEHNLEIN WOLFGANG</creatorcontrib><creatorcontrib>KALEAS CARROLL KIMBERLY ANN</creatorcontrib><creatorcontrib>ROSENBERG EVA</creatorcontrib><creatorcontrib>YIGZAW YINGES</creatorcontrib><creatorcontrib>KONRAD SUSANNE</creatorcontrib><creatorcontrib>WILLMANN STEFFEN</creatorcontrib><creatorcontrib>GIESE GLEN SCOTT</creatorcontrib><creatorcontrib>SALLIER BERNARD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BIALAS AGATHE</au><au>KOEHNLEIN WOLFGANG</au><au>KALEAS CARROLL KIMBERLY ANN</au><au>ROSENBERG EVA</au><au>YIGZAW YINGES</au><au>KONRAD SUSANNE</au><au>WILLMANN STEFFEN</au><au>GIESE GLEN SCOTT</au><au>SALLIER BERNARD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PURIFICATION OF MULTISPECIFIC ANTIBODIES</title><date>2023-07-31</date><risdate>2023</risdate><abstract>본 발명은 다중특이적 항체를 정제하는 방법을 제공한다. 상기 방법은 포획 크로마토그래피, 제1 혼합 방식 크로마토그래피 및 제2 혼합 방식 크로마토그래피를 수행하는 순차 단계를 포함한다. 일부 양태에서, 본 발명은 다중특이적 항체의 조성물을 제공하고, 상기 조성물은 감소된 수준의 하나 이상의 생성물-특이적 불순물 및/또는 공정-특이적 불순물을 갖는다.
The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In some aspects, the invention provides compositions of multispecific antibodies, which compositions have reduced levels of one or more product-specific impurities and/or process-specific impurities.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PURIFICATION OF MULTISPECIFIC ANTIBODIES |
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