Glutathione and ultrasound sensitive drug carrier for tumor targeting and cancer therapy
The present invention relates to a drug carrier with improved cancer cell targeting ability and increased drug carrying efficiency that can be used for cancer tracking and treatment, and a method for manufacturing the same. More specifically, the present invention relates to a drug carrier in which...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; kor |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | CHOI MOON HYUN NOH SEUNG MAN |
| description | The present invention relates to a drug carrier with improved cancer cell targeting ability and increased drug carrying efficiency that can be used for cancer tracking and treatment, and a method for manufacturing the same. More specifically, the present invention relates to a drug carrier in which a micelle structure is formed using a block copolymer having a disulfide bond and then perfluorocarbon is injected into the micelle, and a method for manufacturing the same. The drug carrier's simultaneous response to ultrasound and glutathione to promote decomposition of the hydrophobic part of the block copolymer polymer, which is a drug carrier, by the chemical action of glutathione, and the mechanism of drug release by the physical action of ultrasonic waves are combined, thereby providing a synergistic effect that can maximize drug release.
본원 발명은 암 추적 및 치료에 이용할 수 있는 암세포 타겟팅 능력 향상과 약물 전달 효율이 증대된 약물전달체 및 이의 제조방법에 대한 것이다. 보다 구체적으로는 다이설파이드(disulfide) 결합을 가지는 블록공중합체를 이용하여 마이셀(micelle) 구조를 형성시킨 후 마이셀의 내부에 퍼플루오로카본(perfluorocarbon)을 주입한 약물전달체 및 이의 제조방법에 대한 것이다. 본원발명에 따른 약물전달체는 초음파와 글루타사이온에 동시에 감응하여 글루타사이온의 화학작용에 의한 약물전달체인 블록공중합 고분자의 소수성 부분이 분해의 촉진 및 초음파에 의한 물리적 작용에 의한 약물 방출의 메커니즘의 융합되어 약물방출을 극대화 할 수 있는 시너지 효과가 있다. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_KR20230090147A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>KR20230090147A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_KR20230090147A3</originalsourceid><addsrcrecordid>eNqNi70KAjEQhNNYiPoOC9ZCvBPkShF_wE4s7I4lt5cLxCRsNoJv7yk-gM3MB_PNVN1PvgjK4GIgwNBB8cKYYxkxU8hO3JOg42LBILMjhj4ySHl8EtmSuGC_T4PBjLMMxJheczXp0Wda_HqmlsfDbX9eUYot5YSGAkl7uVa6qrVu9Hqz3dX_WW_vBDvO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Glutathione and ultrasound sensitive drug carrier for tumor targeting and cancer therapy</title><source>esp@cenet</source><creator>CHOI MOON HYUN ; NOH SEUNG MAN</creator><creatorcontrib>CHOI MOON HYUN ; NOH SEUNG MAN</creatorcontrib><description>The present invention relates to a drug carrier with improved cancer cell targeting ability and increased drug carrying efficiency that can be used for cancer tracking and treatment, and a method for manufacturing the same. More specifically, the present invention relates to a drug carrier in which a micelle structure is formed using a block copolymer having a disulfide bond and then perfluorocarbon is injected into the micelle, and a method for manufacturing the same. The drug carrier's simultaneous response to ultrasound and glutathione to promote decomposition of the hydrophobic part of the block copolymer polymer, which is a drug carrier, by the chemical action of glutathione, and the mechanism of drug release by the physical action of ultrasonic waves are combined, thereby providing a synergistic effect that can maximize drug release.
본원 발명은 암 추적 및 치료에 이용할 수 있는 암세포 타겟팅 능력 향상과 약물 전달 효율이 증대된 약물전달체 및 이의 제조방법에 대한 것이다. 보다 구체적으로는 다이설파이드(disulfide) 결합을 가지는 블록공중합체를 이용하여 마이셀(micelle) 구조를 형성시킨 후 마이셀의 내부에 퍼플루오로카본(perfluorocarbon)을 주입한 약물전달체 및 이의 제조방법에 대한 것이다. 본원발명에 따른 약물전달체는 초음파와 글루타사이온에 동시에 감응하여 글루타사이온의 화학작용에 의한 약물전달체인 블록공중합 고분자의 소수성 부분이 분해의 촉진 및 초음파에 의한 물리적 작용에 의한 약물 방출의 메커니즘의 융합되어 약물방출을 극대화 할 수 있는 시너지 효과가 있다.</description><language>eng ; kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230621&DB=EPODOC&CC=KR&NR=20230090147A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230621&DB=EPODOC&CC=KR&NR=20230090147A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHOI MOON HYUN</creatorcontrib><creatorcontrib>NOH SEUNG MAN</creatorcontrib><title>Glutathione and ultrasound sensitive drug carrier for tumor targeting and cancer therapy</title><description>The present invention relates to a drug carrier with improved cancer cell targeting ability and increased drug carrying efficiency that can be used for cancer tracking and treatment, and a method for manufacturing the same. More specifically, the present invention relates to a drug carrier in which a micelle structure is formed using a block copolymer having a disulfide bond and then perfluorocarbon is injected into the micelle, and a method for manufacturing the same. The drug carrier's simultaneous response to ultrasound and glutathione to promote decomposition of the hydrophobic part of the block copolymer polymer, which is a drug carrier, by the chemical action of glutathione, and the mechanism of drug release by the physical action of ultrasonic waves are combined, thereby providing a synergistic effect that can maximize drug release.
본원 발명은 암 추적 및 치료에 이용할 수 있는 암세포 타겟팅 능력 향상과 약물 전달 효율이 증대된 약물전달체 및 이의 제조방법에 대한 것이다. 보다 구체적으로는 다이설파이드(disulfide) 결합을 가지는 블록공중합체를 이용하여 마이셀(micelle) 구조를 형성시킨 후 마이셀의 내부에 퍼플루오로카본(perfluorocarbon)을 주입한 약물전달체 및 이의 제조방법에 대한 것이다. 본원발명에 따른 약물전달체는 초음파와 글루타사이온에 동시에 감응하여 글루타사이온의 화학작용에 의한 약물전달체인 블록공중합 고분자의 소수성 부분이 분해의 촉진 및 초음파에 의한 물리적 작용에 의한 약물 방출의 메커니즘의 융합되어 약물방출을 극대화 할 수 있는 시너지 효과가 있다.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi70KAjEQhNNYiPoOC9ZCvBPkShF_wE4s7I4lt5cLxCRsNoJv7yk-gM3MB_PNVN1PvgjK4GIgwNBB8cKYYxkxU8hO3JOg42LBILMjhj4ySHl8EtmSuGC_T4PBjLMMxJheczXp0Wda_HqmlsfDbX9eUYot5YSGAkl7uVa6qrVu9Hqz3dX_WW_vBDvO</recordid><startdate>20230621</startdate><enddate>20230621</enddate><creator>CHOI MOON HYUN</creator><creator>NOH SEUNG MAN</creator><scope>EVB</scope></search><sort><creationdate>20230621</creationdate><title>Glutathione and ultrasound sensitive drug carrier for tumor targeting and cancer therapy</title><author>CHOI MOON HYUN ; NOH SEUNG MAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20230090147A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHOI MOON HYUN</creatorcontrib><creatorcontrib>NOH SEUNG MAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHOI MOON HYUN</au><au>NOH SEUNG MAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Glutathione and ultrasound sensitive drug carrier for tumor targeting and cancer therapy</title><date>2023-06-21</date><risdate>2023</risdate><abstract>The present invention relates to a drug carrier with improved cancer cell targeting ability and increased drug carrying efficiency that can be used for cancer tracking and treatment, and a method for manufacturing the same. More specifically, the present invention relates to a drug carrier in which a micelle structure is formed using a block copolymer having a disulfide bond and then perfluorocarbon is injected into the micelle, and a method for manufacturing the same. The drug carrier's simultaneous response to ultrasound and glutathione to promote decomposition of the hydrophobic part of the block copolymer polymer, which is a drug carrier, by the chemical action of glutathione, and the mechanism of drug release by the physical action of ultrasonic waves are combined, thereby providing a synergistic effect that can maximize drug release.
본원 발명은 암 추적 및 치료에 이용할 수 있는 암세포 타겟팅 능력 향상과 약물 전달 효율이 증대된 약물전달체 및 이의 제조방법에 대한 것이다. 보다 구체적으로는 다이설파이드(disulfide) 결합을 가지는 블록공중합체를 이용하여 마이셀(micelle) 구조를 형성시킨 후 마이셀의 내부에 퍼플루오로카본(perfluorocarbon)을 주입한 약물전달체 및 이의 제조방법에 대한 것이다. 본원발명에 따른 약물전달체는 초음파와 글루타사이온에 동시에 감응하여 글루타사이온의 화학작용에 의한 약물전달체인 블록공중합 고분자의 소수성 부분이 분해의 촉진 및 초음파에 의한 물리적 작용에 의한 약물 방출의 메커니즘의 융합되어 약물방출을 극대화 할 수 있는 시너지 효과가 있다.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; kor |
| recordid | cdi_epo_espacenet_KR20230090147A |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Glutathione and ultrasound sensitive drug carrier for tumor targeting and cancer therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T21%3A09%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CHOI%20MOON%20HYUN&rft.date=2023-06-21&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EKR20230090147A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |