ADCANTIBODY DRUG CONJUGATES ADCS HAVING ENZYMATICALLY CLEAVABLE GROUPS
본 발명은 개선된 특성을 갖는 신규 항체 약물 접합체 (ADC), 상기 ADC의 활성 대사물 및 그의 제조 방법에 관한 것이다. 본 발명은 또한 질환의 치료 및/또는 예방을 위한 상기 접합체의 용도, 및 질환, 특히 과다증식성 및/또는 혈관신생 질환, 예컨대, 예를 들어, 암 질환의 치료 및/또는 예방을 위한 의약의 제조를 위한 상기 접합체의 용도에 관한 것이다. The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to act...
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| creator | REBSTOCK ANNE SOPHIE DIETZ LISA HAMMER STEFANIE MAHLERT CHRISTOPH KIRCHHOFF DENNIS LERCHEN HANS GEORG STELTE LUDWIG BEATRIX SOMMER ANETTE GREVEN SIMONE MAERSCH STEPHAN BERNDT SANDRA |
| description | 본 발명은 개선된 특성을 갖는 신규 항체 약물 접합체 (ADC), 상기 ADC의 활성 대사물 및 그의 제조 방법에 관한 것이다. 본 발명은 또한 질환의 치료 및/또는 예방을 위한 상기 접합체의 용도, 및 질환, 특히 과다증식성 및/또는 혈관신생 질환, 예컨대, 예를 들어, 암 질환의 치료 및/또는 예방을 위한 의약의 제조를 위한 상기 접합체의 용도에 관한 것이다.
The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. |
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The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.</description><language>eng ; kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230613&DB=EPODOC&CC=KR&NR=20230084612A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230613&DB=EPODOC&CC=KR&NR=20230084612A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>REBSTOCK ANNE SOPHIE</creatorcontrib><creatorcontrib>DIETZ LISA</creatorcontrib><creatorcontrib>HAMMER STEFANIE</creatorcontrib><creatorcontrib>MAHLERT CHRISTOPH</creatorcontrib><creatorcontrib>KIRCHHOFF DENNIS</creatorcontrib><creatorcontrib>LERCHEN HANS GEORG</creatorcontrib><creatorcontrib>STELTE LUDWIG BEATRIX</creatorcontrib><creatorcontrib>SOMMER ANETTE</creatorcontrib><creatorcontrib>GREVEN SIMONE</creatorcontrib><creatorcontrib>MAERSCH STEPHAN</creatorcontrib><creatorcontrib>BERNDT SANDRA</creatorcontrib><title>ADCANTIBODY DRUG CONJUGATES ADCS HAVING ENZYMATICALLY CLEAVABLE GROUPS</title><description>본 발명은 개선된 특성을 갖는 신규 항체 약물 접합체 (ADC), 상기 ADC의 활성 대사물 및 그의 제조 방법에 관한 것이다. 본 발명은 또한 질환의 치료 및/또는 예방을 위한 상기 접합체의 용도, 및 질환, 특히 과다증식성 및/또는 혈관신생 질환, 예컨대, 예를 들어, 암 질환의 치료 및/또는 예방을 위한 의약의 제조를 위한 상기 접합체의 용도에 관한 것이다.
The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBzdHF29AvxdPJ3iVRwCQp1V3D29_MKdXcMcQ1WAMoFK3g4hnn6uSu4-kVF-jqGeDo7-vhEKjj7uDqGOTr5uCq4B_mHBgTzMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JJ47yAjAyNjAwMLEzNDI0dj4lQBAGsVLUU</recordid><startdate>20230613</startdate><enddate>20230613</enddate><creator>REBSTOCK ANNE SOPHIE</creator><creator>DIETZ LISA</creator><creator>HAMMER STEFANIE</creator><creator>MAHLERT CHRISTOPH</creator><creator>KIRCHHOFF DENNIS</creator><creator>LERCHEN HANS GEORG</creator><creator>STELTE LUDWIG BEATRIX</creator><creator>SOMMER ANETTE</creator><creator>GREVEN SIMONE</creator><creator>MAERSCH STEPHAN</creator><creator>BERNDT SANDRA</creator><scope>EVB</scope></search><sort><creationdate>20230613</creationdate><title>ADCANTIBODY DRUG CONJUGATES ADCS HAVING ENZYMATICALLY CLEAVABLE GROUPS</title><author>REBSTOCK ANNE SOPHIE ; DIETZ LISA ; HAMMER STEFANIE ; MAHLERT CHRISTOPH ; KIRCHHOFF DENNIS ; LERCHEN HANS GEORG ; STELTE LUDWIG BEATRIX ; SOMMER ANETTE ; GREVEN SIMONE ; MAERSCH STEPHAN ; BERNDT SANDRA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20230084612A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>REBSTOCK ANNE SOPHIE</creatorcontrib><creatorcontrib>DIETZ LISA</creatorcontrib><creatorcontrib>HAMMER STEFANIE</creatorcontrib><creatorcontrib>MAHLERT CHRISTOPH</creatorcontrib><creatorcontrib>KIRCHHOFF DENNIS</creatorcontrib><creatorcontrib>LERCHEN HANS GEORG</creatorcontrib><creatorcontrib>STELTE LUDWIG BEATRIX</creatorcontrib><creatorcontrib>SOMMER ANETTE</creatorcontrib><creatorcontrib>GREVEN SIMONE</creatorcontrib><creatorcontrib>MAERSCH STEPHAN</creatorcontrib><creatorcontrib>BERNDT SANDRA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>REBSTOCK ANNE SOPHIE</au><au>DIETZ LISA</au><au>HAMMER STEFANIE</au><au>MAHLERT CHRISTOPH</au><au>KIRCHHOFF DENNIS</au><au>LERCHEN HANS GEORG</au><au>STELTE LUDWIG BEATRIX</au><au>SOMMER ANETTE</au><au>GREVEN SIMONE</au><au>MAERSCH STEPHAN</au><au>BERNDT SANDRA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ADCANTIBODY DRUG CONJUGATES ADCS HAVING ENZYMATICALLY CLEAVABLE GROUPS</title><date>2023-06-13</date><risdate>2023</risdate><abstract>본 발명은 개선된 특성을 갖는 신규 항체 약물 접합체 (ADC), 상기 ADC의 활성 대사물 및 그의 제조 방법에 관한 것이다. 본 발명은 또한 질환의 치료 및/또는 예방을 위한 상기 접합체의 용도, 및 질환, 특히 과다증식성 및/또는 혈관신생 질환, 예컨대, 예를 들어, 암 질환의 치료 및/또는 예방을 위한 의약의 제조를 위한 상기 접합체의 용도에 관한 것이다.
The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.</abstract><oa>free_for_read</oa></addata></record> |
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| title | ADCANTIBODY DRUG CONJUGATES ADCS HAVING ENZYMATICALLY CLEAVABLE GROUPS |
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