Native C3 Antibody specifically binding to Native C3 and composition for diagnosing mild cognitive impairment comprising thereof

Native C3 Antibody specifically binding to Native C3 and composition for diagnosing mild cognitive impairment comprising thereof

The present invention relates to an antibody that specifically binds to native C3 and a composition for diagnosing mild cognitive impairment containing the same. Specifically, the present invention relates to an antibody or antibody fragment that recognizes a polypeptide containing an amino acid seq...

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Hauptverfasser: KIM YOUNG DEUG, KIM JUNG TAE, PARK BYEONG JOO, JUNG JIN WOOK
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Sprache:eng ; kor
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CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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creator KIM YOUNG DEUG
KIM JUNG TAE
PARK BYEONG JOO
JUNG JIN WOOK
description The present invention relates to an antibody that specifically binds to native C3 and a composition for diagnosing mild cognitive impairment containing the same. Specifically, the present invention relates to an antibody or antibody fragment that recognizes a polypeptide containing an amino acid sequence shown in SEQ ID NO: 3 as an epitope, a composition and kid for diagnosing mild cognitive impairment containing the same, a polynucleotide encoding the antibody, a recombinant expression vector, and cells transformed using the same. The antibodies and antibody fragments provided by the present invention specifically bind to complement C3 with high sensitivity and can be usefully used to diagnose mild cognitive impairment. Native C3에 특이적으로 결합하는 항체 및 이를 포함하는 경도인지장애 진단용 조성물에 관한 것으로, 상세하게는 서열번호 3으로 표시되는 아미노산 서열을 포함하는 폴리펩티드를 항원 결정부(epitope)로 인식하는 항체 또는 항체의 단편, 이를 포함하는 경도인지장애 진단용 조성물 및 키드, 그리고 상기 항체를 암호화하는 폴리뉴클레오티드와 재조합 발현 벡터 및 이를 이용하여 형질전환 된 세포에 관한 것이다. 본 발명에서 제공하는 항체와 항체의 단편은 높은 감도로 보체 C3에 특이적으로 결합하여, 경도인지장애를 진단하는데 유용하게 이용될 수 있다.
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Specifically, the present invention relates to an antibody or antibody fragment that recognizes a polypeptide containing an amino acid sequence shown in SEQ ID NO: 3 as an epitope, a composition and kid for diagnosing mild cognitive impairment containing the same, a polynucleotide encoding the antibody, a recombinant expression vector, and cells transformed using the same. The antibodies and antibody fragments provided by the present invention specifically bind to complement C3 with high sensitivity and can be usefully used to diagnose mild cognitive impairment. Native C3에 특이적으로 결합하는 항체 및 이를 포함하는 경도인지장애 진단용 조성물에 관한 것으로, 상세하게는 서열번호 3으로 표시되는 아미노산 서열을 포함하는 폴리펩티드를 항원 결정부(epitope)로 인식하는 항체 또는 항체의 단편, 이를 포함하는 경도인지장애 진단용 조성물 및 키드, 그리고 상기 항체를 암호화하는 폴리뉴클레오티드와 재조합 발현 벡터 및 이를 이용하여 형질전환 된 세포에 관한 것이다. 본 발명에서 제공하는 항체와 항체의 단편은 높은 감도로 보체 C3에 특이적으로 결합하여, 경도인지장애를 진단하는데 유용하게 이용될 수 있다.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
title Native C3 Antibody specifically binding to Native C3 and composition for diagnosing mild cognitive impairment comprising thereof
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