CLEAVABLE POLYMER DRUG CONJUGATES

본 발명은, 측쇄 중 하나는 PEG 체인이고 다른 측쇄는 절단가능한 링커에 공유 결합된 하나 이상의 치료학적 물질을 포함하는 적어도 2가지 타입의 측쇄를 가진 (메트)아크릴레이트 기재의 폴리머 백본을 포함하는 폴리머-약물 접합체, 이 폴리머-약물 접합체의 제조 방법, 및 암과 같은 질환의 치료를 위한 이의 용도에 관한 것이다. This invention relates to polymer drug conjugates according to formula I , methods of preparing said polymer-drug co...

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Hauptverfasser: KARACIVI MERVE, ARSLAN MEHMET, SANYAL AMITAV, KAGA SADIK, SUMER BOLU BURCU, GOK OZGUL, SANYAL RANA
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creator KARACIVI MERVE
ARSLAN MEHMET
SANYAL AMITAV
KAGA SADIK
SUMER BOLU BURCU
GOK OZGUL
SANYAL RANA
description 본 발명은, 측쇄 중 하나는 PEG 체인이고 다른 측쇄는 절단가능한 링커에 공유 결합된 하나 이상의 치료학적 물질을 포함하는 적어도 2가지 타입의 측쇄를 가진 (메트)아크릴레이트 기재의 폴리머 백본을 포함하는 폴리머-약물 접합체, 이 폴리머-약물 접합체의 제조 방법, 및 암과 같은 질환의 치료를 위한 이의 용도에 관한 것이다. This invention relates to polymer drug conjugates according to formula I , methods of preparing said polymer-drug conjugates and their use for treatment of diseases such as cancer.
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subjects CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
title CLEAVABLE POLYMER DRUG CONJUGATES
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