COMPOSITION FOR ANTIOXIDANT ANTI-INFLAMMATORY AND DEMENTIA PREVENTION OR IMPROVEMENT COMPRISING PROTEIN EXPRESSION INHIBITOR AND USE THEREOF
The present invention relates to a composition for preventing or alleviating antioxidant, anti-inflammatory, and dementia comprising a protein expression inhibitor and uses thereof. The composition inhibits neuronal cell death caused by dementia-inducing toxic substances in nerve cells and has an ex...
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| creator | EOM SU YEONG LEE HAE RI JEONG AE JIN LEE SONG HEE SEO EUN BI KWON YONG JIN YE SANG KYU NOH KUM HEE KIM SEUL KI PARK SANG HYUN |
| description | The present invention relates to a composition for preventing or alleviating antioxidant, anti-inflammatory, and dementia comprising a protein expression inhibitor and uses thereof. The composition inhibits neuronal cell death caused by dementia-inducing toxic substances in nerve cells and has an excellent neuronal protective effect, thereby preventing and alleviating nerve cell damage and exhibiting therapeutic effects. In addition, the composition effectively inhibits inflammation-inducing factors induced in activated microglial cells to have an excellent anti-inflammatory effect, thereby preventing or treating neuroinflammation-related diseases. In addition, it was confirmed that the composition exhibits a protective effect against neuronal cell death in nerve cells and inhibits neuroinflammation in activated microglial cells, which can be effective as a pharmaceutical composition which has established a new therapeutic target in cranial nerve diseases accompanied by neuronal cell death and neuroinflammation.
본 발명은 단백질 발현 억제제를 포함하는 항산화, 항염 및 치매의 예방 또는 개선용 조성물 및 이의 용도에 관한 것으로, 신경세포에서 치매 유발 독성 물질에 의해 유발되는 신경세포사멸을 억제하고 우수한 신경세포 보호 효과를 가지며, 이로 인하여 신경세포 손상의 예방, 개선 및 치료 효과가 나타낼 수 있고, 활성화된 미세아교 세포에서 유도되는 염증 유발 인자를 효과적으로 저해함으로써 우수한 염증 억제 효과를 가지며, 이로 인하여 신경염증 관련 질환에 대하여 예방 또는 치료할 수 있다. 또한, 신경세포에서의 신경 세포사멸에 대해 보호작용을 나타냄을 확인하고, 활성화된 미세야교 세포에서 신경염증을 억제함을 확인한 것으로, 이는 신경세포사멸 및 신경염증이 동반되는 뇌신경질환에서 새로운 치료타겟을 확립한 약학 조성물로 효과를 나타낼 수 있다. |
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본 발명은 단백질 발현 억제제를 포함하는 항산화, 항염 및 치매의 예방 또는 개선용 조성물 및 이의 용도에 관한 것으로, 신경세포에서 치매 유발 독성 물질에 의해 유발되는 신경세포사멸을 억제하고 우수한 신경세포 보호 효과를 가지며, 이로 인하여 신경세포 손상의 예방, 개선 및 치료 효과가 나타낼 수 있고, 활성화된 미세아교 세포에서 유도되는 염증 유발 인자를 효과적으로 저해함으로써 우수한 염증 억제 효과를 가지며, 이로 인하여 신경염증 관련 질환에 대하여 예방 또는 치료할 수 있다. 또한, 신경세포에서의 신경 세포사멸에 대해 보호작용을 나타냄을 확인하고, 활성화된 미세야교 세포에서 신경염증을 억제함을 확인한 것으로, 이는 신경세포사멸 및 신경염증이 동반되는 뇌신경질환에서 새로운 치료타겟을 확립한 약학 조성물로 효과를 나타낼 수 있다.</description><language>eng ; kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221208&DB=EPODOC&CC=KR&NR=20220162675A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221208&DB=EPODOC&CC=KR&NR=20220162675A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>EOM SU YEONG</creatorcontrib><creatorcontrib>LEE HAE RI</creatorcontrib><creatorcontrib>JEONG AE JIN</creatorcontrib><creatorcontrib>LEE SONG HEE</creatorcontrib><creatorcontrib>SEO EUN BI</creatorcontrib><creatorcontrib>KWON YONG JIN</creatorcontrib><creatorcontrib>YE SANG KYU</creatorcontrib><creatorcontrib>NOH KUM HEE</creatorcontrib><creatorcontrib>KIM SEUL KI</creatorcontrib><creatorcontrib>PARK SANG HYUN</creatorcontrib><title>COMPOSITION FOR ANTIOXIDANT ANTI-INFLAMMATORY AND DEMENTIA PREVENTION OR IMPROVEMENT COMPRISING PROTEIN EXPRESSION INHIBITOR AND USE THEREOF</title><description>The present invention relates to a composition for preventing or alleviating antioxidant, anti-inflammatory, and dementia comprising a protein expression inhibitor and uses thereof. The composition inhibits neuronal cell death caused by dementia-inducing toxic substances in nerve cells and has an excellent neuronal protective effect, thereby preventing and alleviating nerve cell damage and exhibiting therapeutic effects. In addition, the composition effectively inhibits inflammation-inducing factors induced in activated microglial cells to have an excellent anti-inflammatory effect, thereby preventing or treating neuroinflammation-related diseases. In addition, it was confirmed that the composition exhibits a protective effect against neuronal cell death in nerve cells and inhibits neuroinflammation in activated microglial cells, which can be effective as a pharmaceutical composition which has established a new therapeutic target in cranial nerve diseases accompanied by neuronal cell death and neuroinflammation.
본 발명은 단백질 발현 억제제를 포함하는 항산화, 항염 및 치매의 예방 또는 개선용 조성물 및 이의 용도에 관한 것으로, 신경세포에서 치매 유발 독성 물질에 의해 유발되는 신경세포사멸을 억제하고 우수한 신경세포 보호 효과를 가지며, 이로 인하여 신경세포 손상의 예방, 개선 및 치료 효과가 나타낼 수 있고, 활성화된 미세아교 세포에서 유도되는 염증 유발 인자를 효과적으로 저해함으로써 우수한 염증 억제 효과를 가지며, 이로 인하여 신경염증 관련 질환에 대하여 예방 또는 치료할 수 있다. 또한, 신경세포에서의 신경 세포사멸에 대해 보호작용을 나타냄을 확인하고, 활성화된 미세야교 세포에서 신경염증을 억제함을 확인한 것으로, 이는 신경세포사멸 및 신경염증이 동반되는 뇌신경질환에서 새로운 치료타겟을 확립한 약학 조성물로 효과를 나타낼 수 있다.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjcEKwjAQRHvxIOo_BDwXasR6js3GLppsSWKpp1IknkQL9TP8aNPiB3iaYefNzjz5FKQrcuiRDFNkmTDRNiijTj5Fo85Ca-HJXuNFMgkaYiBYZaEeXWzGIurKUj1lbHxq0aE5Rog8oGHQRNy5EUZT4gH9NCbZxQHzJVggtUxm9-4xhNVPF8lagS_KNPSvNgx9dwvP8G5PlmecZ5uc5_ud2P5HfQH8ikFX</recordid><startdate>20221208</startdate><enddate>20221208</enddate><creator>EOM SU YEONG</creator><creator>LEE HAE RI</creator><creator>JEONG AE JIN</creator><creator>LEE SONG HEE</creator><creator>SEO EUN BI</creator><creator>KWON YONG JIN</creator><creator>YE SANG KYU</creator><creator>NOH KUM HEE</creator><creator>KIM SEUL KI</creator><creator>PARK SANG HYUN</creator><scope>EVB</scope></search><sort><creationdate>20221208</creationdate><title>COMPOSITION FOR ANTIOXIDANT ANTI-INFLAMMATORY AND DEMENTIA PREVENTION OR IMPROVEMENT COMPRISING PROTEIN EXPRESSION INHIBITOR AND USE THEREOF</title><author>EOM SU YEONG ; LEE HAE RI ; JEONG AE JIN ; LEE SONG HEE ; SEO EUN BI ; KWON YONG JIN ; YE SANG KYU ; NOH KUM HEE ; KIM SEUL KI ; PARK SANG HYUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20220162675A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2022</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>EOM SU YEONG</creatorcontrib><creatorcontrib>LEE HAE RI</creatorcontrib><creatorcontrib>JEONG AE JIN</creatorcontrib><creatorcontrib>LEE SONG HEE</creatorcontrib><creatorcontrib>SEO EUN BI</creatorcontrib><creatorcontrib>KWON YONG JIN</creatorcontrib><creatorcontrib>YE SANG KYU</creatorcontrib><creatorcontrib>NOH KUM HEE</creatorcontrib><creatorcontrib>KIM SEUL KI</creatorcontrib><creatorcontrib>PARK SANG HYUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>EOM SU YEONG</au><au>LEE HAE RI</au><au>JEONG AE JIN</au><au>LEE SONG HEE</au><au>SEO EUN BI</au><au>KWON YONG JIN</au><au>YE SANG KYU</au><au>NOH KUM HEE</au><au>KIM SEUL KI</au><au>PARK SANG HYUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITION FOR ANTIOXIDANT ANTI-INFLAMMATORY AND DEMENTIA PREVENTION OR IMPROVEMENT COMPRISING PROTEIN EXPRESSION INHIBITOR AND USE THEREOF</title><date>2022-12-08</date><risdate>2022</risdate><abstract>The present invention relates to a composition for preventing or alleviating antioxidant, anti-inflammatory, and dementia comprising a protein expression inhibitor and uses thereof. The composition inhibits neuronal cell death caused by dementia-inducing toxic substances in nerve cells and has an excellent neuronal protective effect, thereby preventing and alleviating nerve cell damage and exhibiting therapeutic effects. In addition, the composition effectively inhibits inflammation-inducing factors induced in activated microglial cells to have an excellent anti-inflammatory effect, thereby preventing or treating neuroinflammation-related diseases. In addition, it was confirmed that the composition exhibits a protective effect against neuronal cell death in nerve cells and inhibits neuroinflammation in activated microglial cells, which can be effective as a pharmaceutical composition which has established a new therapeutic target in cranial nerve diseases accompanied by neuronal cell death and neuroinflammation.
본 발명은 단백질 발현 억제제를 포함하는 항산화, 항염 및 치매의 예방 또는 개선용 조성물 및 이의 용도에 관한 것으로, 신경세포에서 치매 유발 독성 물질에 의해 유발되는 신경세포사멸을 억제하고 우수한 신경세포 보호 효과를 가지며, 이로 인하여 신경세포 손상의 예방, 개선 및 치료 효과가 나타낼 수 있고, 활성화된 미세아교 세포에서 유도되는 염증 유발 인자를 효과적으로 저해함으로써 우수한 염증 억제 효과를 가지며, 이로 인하여 신경염증 관련 질환에 대하여 예방 또는 치료할 수 있다. 또한, 신경세포에서의 신경 세포사멸에 대해 보호작용을 나타냄을 확인하고, 활성화된 미세야교 세포에서 신경염증을 억제함을 확인한 것으로, 이는 신경세포사멸 및 신경염증이 동반되는 뇌신경질환에서 새로운 치료타겟을 확립한 약학 조성물로 효과를 나타낼 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| title | COMPOSITION FOR ANTIOXIDANT ANTI-INFLAMMATORY AND DEMENTIA PREVENTION OR IMPROVEMENT COMPRISING PROTEIN EXPRESSION INHIBITOR AND USE THEREOF |
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