간 약독화 마이코박테리아의 폐 전달에 의한 치료학적 효과
본 발명은 필요한 인간 개체에서 요법에 사용하기 위한, i) phoP의 오픈 리딩 프래임 (ORF) 서열이 서열번호 4로 구성되는, Rv0757 유전자의 유전자 결손에 의한 비활성화로 인한 PhoP- 표현형, 및 ii) fadD26의 오픈 리딩 프래임 (ORF) 서열이 서열번호 2로 구성되는, PDIM 생성을 방지하는 (PDIM- 표현형), 제2 유전자 Rv2930 (fadD26)의 결손을 가진, 마이코박테리움 투베르쿨로시스 MTBVAC 균주에 속하는 단리된 미생물을 포함하는, 폐 전달을 통해 개체에 투여되는, 생균-약독화 마이코박...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | kor |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | MARTIN MONTANES CARLOS VANEVA MARINOVA DESSISLAVA MATA LOZANO ELENA URANGA MAIZ SANTIAGO AGUILO JUAN IGNACIO TARANCON INIGUEZ RAQUEL |
| description | 본 발명은 필요한 인간 개체에서 요법에 사용하기 위한, i) phoP의 오픈 리딩 프래임 (ORF) 서열이 서열번호 4로 구성되는, Rv0757 유전자의 유전자 결손에 의한 비활성화로 인한 PhoP- 표현형, 및 ii) fadD26의 오픈 리딩 프래임 (ORF) 서열이 서열번호 2로 구성되는, PDIM 생성을 방지하는 (PDIM- 표현형), 제2 유전자 Rv2930 (fadD26)의 결손을 가진, 마이코박테리움 투베르쿨로시스 MTBVAC 균주에 속하는 단리된 미생물을 포함하는, 폐 전달을 통해 개체에 투여되는, 생균-약독화 마이코박테리움 투베르쿨로시스 조성물에 관한 것이다.
The present invention is directed to a live-attenuated Mycobacterium tuberculosis composition comprising an isolated microorganism belonging to a M. tuberculosis MTBVAC strain having a i) PhoP- phenotype by the inactivation by a genetic deletion of the Rv0757 gene, wherein the open-reading frame (ORF) sequence of phoP consists of SEQ ID NO 4, and ii) the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM- phenotype), wherein the open-reading frame (ORF) sequence of fadD26 consists of SEQ ID NO 2, for use in therapy in a human subject in need thereof, wherein the composition is administered to said subject via pulmonary delivery. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_KR20220097398A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>KR20220097398A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_KR20220097398A3</originalsourceid><addsrcrecordid>eNrjZPB_taFF4c3Uva_7W9_OnKLwennHm7lb3uyd8nrD1LetPa-XrXkzteXN3BkKb_snKLxZ0PK6e82b6UDW3Blvp85ReLNzxuvFPW-nznyzoFHh7awVrzbv4WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8d5BRgZGRgYGlubGlhaOxsSpAgDB5k43</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>간 약독화 마이코박테리아의 폐 전달에 의한 치료학적 효과</title><source>esp@cenet</source><creator>MARTIN MONTANES CARLOS ; VANEVA MARINOVA DESSISLAVA ; MATA LOZANO ELENA ; URANGA MAIZ SANTIAGO ; AGUILO JUAN IGNACIO ; TARANCON INIGUEZ RAQUEL</creator><creatorcontrib>MARTIN MONTANES CARLOS ; VANEVA MARINOVA DESSISLAVA ; MATA LOZANO ELENA ; URANGA MAIZ SANTIAGO ; AGUILO JUAN IGNACIO ; TARANCON INIGUEZ RAQUEL</creatorcontrib><description>본 발명은 필요한 인간 개체에서 요법에 사용하기 위한, i) phoP의 오픈 리딩 프래임 (ORF) 서열이 서열번호 4로 구성되는, Rv0757 유전자의 유전자 결손에 의한 비활성화로 인한 PhoP- 표현형, 및 ii) fadD26의 오픈 리딩 프래임 (ORF) 서열이 서열번호 2로 구성되는, PDIM 생성을 방지하는 (PDIM- 표현형), 제2 유전자 Rv2930 (fadD26)의 결손을 가진, 마이코박테리움 투베르쿨로시스 MTBVAC 균주에 속하는 단리된 미생물을 포함하는, 폐 전달을 통해 개체에 투여되는, 생균-약독화 마이코박테리움 투베르쿨로시스 조성물에 관한 것이다.
The present invention is directed to a live-attenuated Mycobacterium tuberculosis composition comprising an isolated microorganism belonging to a M. tuberculosis MTBVAC strain having a i) PhoP- phenotype by the inactivation by a genetic deletion of the Rv0757 gene, wherein the open-reading frame (ORF) sequence of phoP consists of SEQ ID NO 4, and ii) the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM- phenotype), wherein the open-reading frame (ORF) sequence of fadD26 consists of SEQ ID NO 2, for use in therapy in a human subject in need thereof, wherein the composition is administered to said subject via pulmonary delivery.</description><language>kor</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220707&DB=EPODOC&CC=KR&NR=20220097398A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220707&DB=EPODOC&CC=KR&NR=20220097398A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MARTIN MONTANES CARLOS</creatorcontrib><creatorcontrib>VANEVA MARINOVA DESSISLAVA</creatorcontrib><creatorcontrib>MATA LOZANO ELENA</creatorcontrib><creatorcontrib>URANGA MAIZ SANTIAGO</creatorcontrib><creatorcontrib>AGUILO JUAN IGNACIO</creatorcontrib><creatorcontrib>TARANCON INIGUEZ RAQUEL</creatorcontrib><title>간 약독화 마이코박테리아의 폐 전달에 의한 치료학적 효과</title><description>본 발명은 필요한 인간 개체에서 요법에 사용하기 위한, i) phoP의 오픈 리딩 프래임 (ORF) 서열이 서열번호 4로 구성되는, Rv0757 유전자의 유전자 결손에 의한 비활성화로 인한 PhoP- 표현형, 및 ii) fadD26의 오픈 리딩 프래임 (ORF) 서열이 서열번호 2로 구성되는, PDIM 생성을 방지하는 (PDIM- 표현형), 제2 유전자 Rv2930 (fadD26)의 결손을 가진, 마이코박테리움 투베르쿨로시스 MTBVAC 균주에 속하는 단리된 미생물을 포함하는, 폐 전달을 통해 개체에 투여되는, 생균-약독화 마이코박테리움 투베르쿨로시스 조성물에 관한 것이다.
The present invention is directed to a live-attenuated Mycobacterium tuberculosis composition comprising an isolated microorganism belonging to a M. tuberculosis MTBVAC strain having a i) PhoP- phenotype by the inactivation by a genetic deletion of the Rv0757 gene, wherein the open-reading frame (ORF) sequence of phoP consists of SEQ ID NO 4, and ii) the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM- phenotype), wherein the open-reading frame (ORF) sequence of fadD26 consists of SEQ ID NO 2, for use in therapy in a human subject in need thereof, wherein the composition is administered to said subject via pulmonary delivery.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB_taFF4c3Uva_7W9_OnKLwennHm7lb3uyd8nrD1LetPa-XrXkzteXN3BkKb_snKLxZ0PK6e82b6UDW3Blvp85ReLNzxuvFPW-nznyzoFHh7awVrzbv4WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8d5BRgZGRgYGlubGlhaOxsSpAgDB5k43</recordid><startdate>20220707</startdate><enddate>20220707</enddate><creator>MARTIN MONTANES CARLOS</creator><creator>VANEVA MARINOVA DESSISLAVA</creator><creator>MATA LOZANO ELENA</creator><creator>URANGA MAIZ SANTIAGO</creator><creator>AGUILO JUAN IGNACIO</creator><creator>TARANCON INIGUEZ RAQUEL</creator><scope>EVB</scope></search><sort><creationdate>20220707</creationdate><title>간 약독화 마이코박테리아의 폐 전달에 의한 치료학적 효과</title><author>MARTIN MONTANES CARLOS ; VANEVA MARINOVA DESSISLAVA ; MATA LOZANO ELENA ; URANGA MAIZ SANTIAGO ; AGUILO JUAN IGNACIO ; TARANCON INIGUEZ RAQUEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20220097398A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MARTIN MONTANES CARLOS</creatorcontrib><creatorcontrib>VANEVA MARINOVA DESSISLAVA</creatorcontrib><creatorcontrib>MATA LOZANO ELENA</creatorcontrib><creatorcontrib>URANGA MAIZ SANTIAGO</creatorcontrib><creatorcontrib>AGUILO JUAN IGNACIO</creatorcontrib><creatorcontrib>TARANCON INIGUEZ RAQUEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MARTIN MONTANES CARLOS</au><au>VANEVA MARINOVA DESSISLAVA</au><au>MATA LOZANO ELENA</au><au>URANGA MAIZ SANTIAGO</au><au>AGUILO JUAN IGNACIO</au><au>TARANCON INIGUEZ RAQUEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>간 약독화 마이코박테리아의 폐 전달에 의한 치료학적 효과</title><date>2022-07-07</date><risdate>2022</risdate><abstract>본 발명은 필요한 인간 개체에서 요법에 사용하기 위한, i) phoP의 오픈 리딩 프래임 (ORF) 서열이 서열번호 4로 구성되는, Rv0757 유전자의 유전자 결손에 의한 비활성화로 인한 PhoP- 표현형, 및 ii) fadD26의 오픈 리딩 프래임 (ORF) 서열이 서열번호 2로 구성되는, PDIM 생성을 방지하는 (PDIM- 표현형), 제2 유전자 Rv2930 (fadD26)의 결손을 가진, 마이코박테리움 투베르쿨로시스 MTBVAC 균주에 속하는 단리된 미생물을 포함하는, 폐 전달을 통해 개체에 투여되는, 생균-약독화 마이코박테리움 투베르쿨로시스 조성물에 관한 것이다.
The present invention is directed to a live-attenuated Mycobacterium tuberculosis composition comprising an isolated microorganism belonging to a M. tuberculosis MTBVAC strain having a i) PhoP- phenotype by the inactivation by a genetic deletion of the Rv0757 gene, wherein the open-reading frame (ORF) sequence of phoP consists of SEQ ID NO 4, and ii) the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM- phenotype), wherein the open-reading frame (ORF) sequence of fadD26 consists of SEQ ID NO 2, for use in therapy in a human subject in need thereof, wherein the composition is administered to said subject via pulmonary delivery.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | kor |
| recordid | cdi_epo_espacenet_KR20220097398A |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 간 약독화 마이코박테리아의 폐 전달에 의한 치료학적 효과 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T22%3A47%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MARTIN%20MONTANES%20CARLOS&rft.date=2022-07-07&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EKR20220097398A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |