DNA CRYOPROTECTIVE COMPOSITION COMPRISING DNA NANOSTRUCTURES AND METHODS OF USING SAME
본 발명은 기결정된 위치에서 접혀 복수개의 가닥을 이룬 스캐폴드 핵산, 및 적어도 일부가 상기 스캐폴드 핵산과 상보적인 서열을 가져, 상기 가닥 중 적어도 하나에 결합되어 이중 가닥을 형성하는 복수개의 스테이플 핵산을 포함하는 핵산 구조체, 핵산 구조체의 적어도 일부에 결합된 연결자 및 연결자의 적어도 일부에 결합된 펩타이드를 포함함으로써, 동결 보호 효과가 우수하여, 세포 및 조직의 동결 보존 시에 세포의 생존률을 높일 수 있으며, 식품의 동결에 사용시에도 그 식품의 식감을 유지할 수 있도록 하는 동결 보호용 조성물에 관한 것이다...
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| creator | LEE YE DAM KIM DO NYUN LEE CHAN SEOK AHN DONG JUNE |
| description | 본 발명은 기결정된 위치에서 접혀 복수개의 가닥을 이룬 스캐폴드 핵산, 및 적어도 일부가 상기 스캐폴드 핵산과 상보적인 서열을 가져, 상기 가닥 중 적어도 하나에 결합되어 이중 가닥을 형성하는 복수개의 스테이플 핵산을 포함하는 핵산 구조체, 핵산 구조체의 적어도 일부에 결합된 연결자 및 연결자의 적어도 일부에 결합된 펩타이드를 포함함으로써, 동결 보호 효과가 우수하여, 세포 및 조직의 동결 보존 시에 세포의 생존률을 높일 수 있으며, 식품의 동결에 사용시에도 그 식품의 식감을 유지할 수 있도록 하는 동결 보호용 조성물에 관한 것이다.
The present invention relates to a composition for cryopreservation, comprising: a nucleic acid structure which comprises a scaffold nucleic acid folded at predetermined positions to form multiple strands, and a plurality of staple nucleic acids wherein at least a portion of a sequence thereof comprises a complementary sequence to that of the scaffold nucleic acid, which are bound to at least one of the strands of the scaffold nucleic acid to form a double strand; linkers coupled to at least one of single strands in the nucleic acid structure; and an anti-freezing peptide coupled to at least one of the linkers, so as to exhibit excellent freeze-protection effects, which in turn increase cell viability during cryopreservation of cells and tissues, while retaining original texture of food even when used for freezing the food. |
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The present invention relates to a composition for cryopreservation, comprising: a nucleic acid structure which comprises a scaffold nucleic acid folded at predetermined positions to form multiple strands, and a plurality of staple nucleic acids wherein at least a portion of a sequence thereof comprises a complementary sequence to that of the scaffold nucleic acid, which are bound to at least one of the strands of the scaffold nucleic acid to form a double strand; linkers coupled to at least one of single strands in the nucleic acid structure; and an anti-freezing peptide coupled to at least one of the linkers, so as to exhibit excellent freeze-protection effects, which in turn increase cell viability during cryopreservation of cells and tissues, while retaining original texture of food even when used for freezing the food.</description><language>eng ; kor</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; FISHING ; FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES ; TRAPPING</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220613&DB=EPODOC&CC=KR&NR=20220079253A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25571,76555</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220613&DB=EPODOC&CC=KR&NR=20220079253A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEE YE DAM</creatorcontrib><creatorcontrib>KIM DO NYUN</creatorcontrib><creatorcontrib>LEE CHAN SEOK</creatorcontrib><creatorcontrib>AHN DONG JUNE</creatorcontrib><title>DNA CRYOPROTECTIVE COMPOSITION COMPRISING DNA NANOSTRUCTURES AND METHODS OF USING SAME</title><description>본 발명은 기결정된 위치에서 접혀 복수개의 가닥을 이룬 스캐폴드 핵산, 및 적어도 일부가 상기 스캐폴드 핵산과 상보적인 서열을 가져, 상기 가닥 중 적어도 하나에 결합되어 이중 가닥을 형성하는 복수개의 스테이플 핵산을 포함하는 핵산 구조체, 핵산 구조체의 적어도 일부에 결합된 연결자 및 연결자의 적어도 일부에 결합된 펩타이드를 포함함으로써, 동결 보호 효과가 우수하여, 세포 및 조직의 동결 보존 시에 세포의 생존률을 높일 수 있으며, 식품의 동결에 사용시에도 그 식품의 식감을 유지할 수 있도록 하는 동결 보호용 조성물에 관한 것이다.
The present invention relates to a composition for cryopreservation, comprising: a nucleic acid structure which comprises a scaffold nucleic acid folded at predetermined positions to form multiple strands, and a plurality of staple nucleic acids wherein at least a portion of a sequence thereof comprises a complementary sequence to that of the scaffold nucleic acid, which are bound to at least one of the strands of the scaffold nucleic acid to form a double strand; linkers coupled to at least one of single strands in the nucleic acid structure; and an anti-freezing peptide coupled to at least one of the linkers, so as to exhibit excellent freeze-protection effects, which in turn increase cell viability during cryopreservation of cells and tissues, while retaining original texture of food even when used for freezing the food.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>FISHING</subject><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><subject>TRAPPING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEsDqK-w4GzEFJEHEOS2iDJlcul0KkUiZNoob4_YvEBnP5_-Nais1GDoR5bQnaGfefAYGgxefYYlyeffLzAV0YdMTFlw5lcAh0tBMcN2gRYQ15c0sFtxeo-Puay-3Uj9rVj0xzK9BrKPI238izv4UpKKiXl6ayOla7-Ux-gfTII</recordid><startdate>20220613</startdate><enddate>20220613</enddate><creator>LEE YE DAM</creator><creator>KIM DO NYUN</creator><creator>LEE CHAN SEOK</creator><creator>AHN DONG JUNE</creator><scope>EVB</scope></search><sort><creationdate>20220613</creationdate><title>DNA CRYOPROTECTIVE COMPOSITION COMPRISING DNA NANOSTRUCTURES AND METHODS OF USING SAME</title><author>LEE YE DAM ; KIM DO NYUN ; LEE CHAN SEOK ; AHN DONG JUNE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20220079253A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2022</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>FISHING</topic><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><topic>TRAPPING</topic><toplevel>online_resources</toplevel><creatorcontrib>LEE YE DAM</creatorcontrib><creatorcontrib>KIM DO NYUN</creatorcontrib><creatorcontrib>LEE CHAN SEOK</creatorcontrib><creatorcontrib>AHN DONG JUNE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEE YE DAM</au><au>KIM DO NYUN</au><au>LEE CHAN SEOK</au><au>AHN DONG JUNE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DNA CRYOPROTECTIVE COMPOSITION COMPRISING DNA NANOSTRUCTURES AND METHODS OF USING SAME</title><date>2022-06-13</date><risdate>2022</risdate><abstract>본 발명은 기결정된 위치에서 접혀 복수개의 가닥을 이룬 스캐폴드 핵산, 및 적어도 일부가 상기 스캐폴드 핵산과 상보적인 서열을 가져, 상기 가닥 중 적어도 하나에 결합되어 이중 가닥을 형성하는 복수개의 스테이플 핵산을 포함하는 핵산 구조체, 핵산 구조체의 적어도 일부에 결합된 연결자 및 연결자의 적어도 일부에 결합된 펩타이드를 포함함으로써, 동결 보호 효과가 우수하여, 세포 및 조직의 동결 보존 시에 세포의 생존률을 높일 수 있으며, 식품의 동결에 사용시에도 그 식품의 식감을 유지할 수 있도록 하는 동결 보호용 조성물에 관한 것이다.
The present invention relates to a composition for cryopreservation, comprising: a nucleic acid structure which comprises a scaffold nucleic acid folded at predetermined positions to form multiple strands, and a plurality of staple nucleic acids wherein at least a portion of a sequence thereof comprises a complementary sequence to that of the scaffold nucleic acid, which are bound to at least one of the strands of the scaffold nucleic acid to form a double strand; linkers coupled to at least one of single strands in the nucleic acid structure; and an anti-freezing peptide coupled to at least one of the linkers, so as to exhibit excellent freeze-protection effects, which in turn increase cell viability during cryopreservation of cells and tissues, while retaining original texture of food even when used for freezing the food.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J FORESTRY HUMAN NECESSITIES HUNTING METALLURGY ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRAPPING |
| title | DNA CRYOPROTECTIVE COMPOSITION COMPRISING DNA NANOSTRUCTURES AND METHODS OF USING SAME |
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