액티빈 수용체 유사 키나아제 저해제의 염 및 결정 형태
본 발명은 하기 구조식으로 나타나는 화합물 (I)의 각종 염과 그에 따른 제약 조성물을 개시한다. JPEGpct00026.jpg5761(I) 1:1.5 화합물 (I)-숙시네이트, 1:1 화합물 (I)-염산염, 1:1 화합물 (I)-푸마레이트염 중 특정한 단결정 형태를 각종 성질 및 물리적 측량값으로 규정하였다. 본 발명은 또한 특정 단결정 형태의 조제법을 개시한다. 본 개시는 대상체의 진행성 골화성 섬유이형성증을 치료 또는 개선하는 방법을 포함한다. Various salt forms of Compound (I) represented...
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| creator | OHMER HARALD JOHNSTON STEVEN C MEDENDORP CLARE WILKIE GORDON MAZAIK DEBRA HEINRICH BRIAN MACEACHERN LAUREN WAETZIG JOSHUA D SIEGEL DOMINIK |
| description | 본 발명은 하기 구조식으로 나타나는 화합물 (I)의 각종 염과 그에 따른 제약 조성물을 개시한다. JPEGpct00026.jpg5761(I) 1:1.5 화합물 (I)-숙시네이트, 1:1 화합물 (I)-염산염, 1:1 화합물 (I)-푸마레이트염 중 특정한 단결정 형태를 각종 성질 및 물리적 측량값으로 규정하였다. 본 발명은 또한 특정 단결정 형태의 조제법을 개시한다. 본 개시는 대상체의 진행성 골화성 섬유이형성증을 치료 또는 개선하는 방법을 포함한다.
Various salt forms of Compound (I) represented by the following structural formula, and their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1.5 Compound (I) succinate, 1:1 Compound (I) hydrochloride salt, and 1:1 Compound (I) fumarate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating or ameliorating fibrodysplasia ossificans progressive in a subject. |
| format | Patent |
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Various salt forms of Compound (I) represented by the following structural formula, and their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1.5 Compound (I) succinate, 1:1 Compound (I) hydrochloride salt, and 1:1 Compound (I) fumarate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating or ameliorating fibrodysplasia ossificans progressive in a subject.</description><language>kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220428&DB=EPODOC&CC=KR&NR=20220052955A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220428&DB=EPODOC&CC=KR&NR=20220052955A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OHMER HARALD</creatorcontrib><creatorcontrib>JOHNSTON STEVEN C</creatorcontrib><creatorcontrib>MEDENDORP CLARE</creatorcontrib><creatorcontrib>WILKIE GORDON</creatorcontrib><creatorcontrib>MAZAIK DEBRA</creatorcontrib><creatorcontrib>HEINRICH BRIAN</creatorcontrib><creatorcontrib>MACEACHERN LAUREN</creatorcontrib><creatorcontrib>WAETZIG JOSHUA D</creatorcontrib><creatorcontrib>SIEGEL DOMINIK</creatorcontrib><title>액티빈 수용체 유사 키나아제 저해제의 염 및 결정 형태</title><description>본 발명은 하기 구조식으로 나타나는 화합물 (I)의 각종 염과 그에 따른 제약 조성물을 개시한다. JPEGpct00026.jpg5761(I) 1:1.5 화합물 (I)-숙시네이트, 1:1 화합물 (I)-염산염, 1:1 화합물 (I)-푸마레이트염 중 특정한 단결정 형태를 각종 성질 및 물리적 측량값으로 규정하였다. 본 발명은 또한 특정 단결정 형태의 조제법을 개시한다. 본 개시는 대상체의 진행성 골화성 섬유이형성증을 치료 또는 개선하는 방법을 포함한다.
Various salt forms of Compound (I) represented by the following structural formula, and their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1.5 Compound (I) succinate, 1:1 Compound (I) hydrochloride salt, and 1:1 Compound (I) fumarate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating or ameliorating fibrodysplasia ossificans progressive in a subject.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB6M3Xh2-4Nr3d2KLzpmPFm1so3m7YovJmz4E3TGoW3TUteN814M7XlzYI5Cm8WNLydugXIejN3hsKb6XsUXm_oV3i1acObBVMV3s6Y-rZ5Dg8Da1piTnEqL5TmZlB2cw1x9tBNLciPTy0uSExOzUstifcOMjIwMjIwMDWyNDV1NCZOFQBJFEoe</recordid><startdate>20220428</startdate><enddate>20220428</enddate><creator>OHMER HARALD</creator><creator>JOHNSTON STEVEN C</creator><creator>MEDENDORP CLARE</creator><creator>WILKIE GORDON</creator><creator>MAZAIK DEBRA</creator><creator>HEINRICH BRIAN</creator><creator>MACEACHERN LAUREN</creator><creator>WAETZIG JOSHUA D</creator><creator>SIEGEL DOMINIK</creator><scope>EVB</scope></search><sort><creationdate>20220428</creationdate><title>액티빈 수용체 유사 키나아제 저해제의 염 및 결정 형태</title><author>OHMER HARALD ; JOHNSTON STEVEN C ; MEDENDORP CLARE ; WILKIE GORDON ; MAZAIK DEBRA ; HEINRICH BRIAN ; MACEACHERN LAUREN ; WAETZIG JOSHUA D ; SIEGEL DOMINIK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20220052955A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>OHMER HARALD</creatorcontrib><creatorcontrib>JOHNSTON STEVEN C</creatorcontrib><creatorcontrib>MEDENDORP CLARE</creatorcontrib><creatorcontrib>WILKIE GORDON</creatorcontrib><creatorcontrib>MAZAIK DEBRA</creatorcontrib><creatorcontrib>HEINRICH BRIAN</creatorcontrib><creatorcontrib>MACEACHERN LAUREN</creatorcontrib><creatorcontrib>WAETZIG JOSHUA D</creatorcontrib><creatorcontrib>SIEGEL DOMINIK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OHMER HARALD</au><au>JOHNSTON STEVEN C</au><au>MEDENDORP CLARE</au><au>WILKIE GORDON</au><au>MAZAIK DEBRA</au><au>HEINRICH BRIAN</au><au>MACEACHERN LAUREN</au><au>WAETZIG JOSHUA D</au><au>SIEGEL DOMINIK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>액티빈 수용체 유사 키나아제 저해제의 염 및 결정 형태</title><date>2022-04-28</date><risdate>2022</risdate><abstract>본 발명은 하기 구조식으로 나타나는 화합물 (I)의 각종 염과 그에 따른 제약 조성물을 개시한다. JPEGpct00026.jpg5761(I) 1:1.5 화합물 (I)-숙시네이트, 1:1 화합물 (I)-염산염, 1:1 화합물 (I)-푸마레이트염 중 특정한 단결정 형태를 각종 성질 및 물리적 측량값으로 규정하였다. 본 발명은 또한 특정 단결정 형태의 조제법을 개시한다. 본 개시는 대상체의 진행성 골화성 섬유이형성증을 치료 또는 개선하는 방법을 포함한다.
Various salt forms of Compound (I) represented by the following structural formula, and their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1.5 Compound (I) succinate, 1:1 Compound (I) hydrochloride salt, and 1:1 Compound (I) fumarate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating or ameliorating fibrodysplasia ossificans progressive in a subject.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 액티빈 수용체 유사 키나아제 저해제의 염 및 결정 형태 |
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