enveloped viruses Pharmaceutical composition for the prevention and treatment of Envelopled viruses comprising taining Platycodon grandiflorus root extracts
The present invention relates to a pharmaceutical composition for the prevention and treatment of COVID-19 containing a Platycodon grandiflorum extract and platycodin D as active components. More specifically, the present invention relates to a pharmaceutical composition for prevention and treatment...
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| creator | LEE C.JUSTIN KIM TAI YOUNG |
| description | The present invention relates to a pharmaceutical composition for the prevention and treatment of COVID-19 containing a Platycodon grandiflorum extract and platycodin D as active components. More specifically, the present invention relates to a pharmaceutical composition for prevention and treatment of COVID-19 by inhibiting cellular infection of COVID-19 and inhibiting the production of intracellular infectious virus of platicodin D, a component contained in Platycodon grandiflorum, and a method for preventing and treating COVID-19 by using the pharmaceutical composition. The Platycodon grandiflorum extract or platycodin D, an active component thereof exhibits a remarkable inhibitory effect on cell entry and cell infection of coronavirus, and is confirmed to exhibit a more pronounced effect than chloroquine, camostat, and nafamostat, which are treatment candidates through inhibition of cell entry and cell infection of coronavirus. Through the same, the pharmaceutical composition can be usefully used to prevent coronavirus or to treat early stages of infection. In addition, the Platycodon grandiflorum extract or platycodin D inhibits the cleavage of the spike protein important for infection during packaging of coronavirus, thereby inhibiting the proliferation and spread of the infectious coronavirus in cells. Therefore, the composition of the present invention is useful for the prevention and treatment of coronavirus.
본 발명은 길경(桔梗) 추출물 및 플라티코딘 D(Platycodin D)를 유효성분으로 함유하는 COVID-19의 예방 및 치료용 약학 조성물에 관한 것으로, 보다 상세하게는 길경에 함유된 성분인 플라티코딘 D의 코로나 바이러스 19에 대한 세포 감염 억제 및 세포 내 감염성 바이러스의 생산 저해를 통한 COVID-19의 예방 및 치료용 약학 조성물 및 상기 약학 조성물을 이용한 COVID-19의 예방 및 치료방법에 관한 것으로, 본 발명의 길경 추출물 또는 이의 유효성분인 플라티코딘 D는 코로나 바이러스의 세포 진입 및 세포 감염에 대해 현저한 억제 효과를 나타내며, 코로나 바이러스의 세포 진입 및 세포 감염의 억제를 통한 치료 후보 물질인 클로로퀸 (Chloroquine), 카모스타트(Camostat), 나파모스타트 (Nafamostat)보다 현저한 효과를 나타냄을 확인하였다. 이를 통해, 코로나 바이러스를 예방하거나, 감염 초기 단계의 치료에 유용하게 사용될 수 있다. 또한, 상기 길경 추출물 또는 플라티코딘 D는 코로나바이스의 패키징 시 감염에 중요한 스파이크 단백질의 절단을 억제함으로써, 세포 내 감염성 코로나 바이러스의 증식 및 확산을 억제하는 효과를 나타낸다. 따라서, 본 발명의 조성믈은 코로나 바이러스의 예방 및 치료에 유용하다. |
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본 발명은 길경(桔梗) 추출물 및 플라티코딘 D(Platycodin D)를 유효성분으로 함유하는 COVID-19의 예방 및 치료용 약학 조성물에 관한 것으로, 보다 상세하게는 길경에 함유된 성분인 플라티코딘 D의 코로나 바이러스 19에 대한 세포 감염 억제 및 세포 내 감염성 바이러스의 생산 저해를 통한 COVID-19의 예방 및 치료용 약학 조성물 및 상기 약학 조성물을 이용한 COVID-19의 예방 및 치료방법에 관한 것으로, 본 발명의 길경 추출물 또는 이의 유효성분인 플라티코딘 D는 코로나 바이러스의 세포 진입 및 세포 감염에 대해 현저한 억제 효과를 나타내며, 코로나 바이러스의 세포 진입 및 세포 감염의 억제를 통한 치료 후보 물질인 클로로퀸 (Chloroquine), 카모스타트(Camostat), 나파모스타트 (Nafamostat)보다 현저한 효과를 나타냄을 확인하였다. 이를 통해, 코로나 바이러스를 예방하거나, 감염 초기 단계의 치료에 유용하게 사용될 수 있다. 또한, 상기 길경 추출물 또는 플라티코딘 D는 코로나바이스의 패키징 시 감염에 중요한 스파이크 단백질의 절단을 억제함으로써, 세포 내 감염성 코로나 바이러스의 증식 및 확산을 억제하는 효과를 나타낸다. 따라서, 본 발명의 조성믈은 코로나 바이러스의 예방 및 치료에 유용하다.</description><language>eng ; kor</language><subject>FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220215&DB=EPODOC&CC=KR&NR=20220018919A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220215&DB=EPODOC&CC=KR&NR=20220018919A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEE C.JUSTIN</creatorcontrib><creatorcontrib>KIM TAI YOUNG</creatorcontrib><title>enveloped viruses Pharmaceutical composition for the prevention and treatment of Envelopled viruses comprising taining Platycodon grandiflorus root extracts</title><description>The present invention relates to a pharmaceutical composition for the prevention and treatment of COVID-19 containing a Platycodon grandiflorum extract and platycodin D as active components. More specifically, the present invention relates to a pharmaceutical composition for prevention and treatment of COVID-19 by inhibiting cellular infection of COVID-19 and inhibiting the production of intracellular infectious virus of platicodin D, a component contained in Platycodon grandiflorum, and a method for preventing and treating COVID-19 by using the pharmaceutical composition. The Platycodon grandiflorum extract or platycodin D, an active component thereof exhibits a remarkable inhibitory effect on cell entry and cell infection of coronavirus, and is confirmed to exhibit a more pronounced effect than chloroquine, camostat, and nafamostat, which are treatment candidates through inhibition of cell entry and cell infection of coronavirus. Through the same, the pharmaceutical composition can be usefully used to prevent coronavirus or to treat early stages of infection. In addition, the Platycodon grandiflorum extract or platycodin D inhibits the cleavage of the spike protein important for infection during packaging of coronavirus, thereby inhibiting the proliferation and spread of the infectious coronavirus in cells. Therefore, the composition of the present invention is useful for the prevention and treatment of coronavirus.
본 발명은 길경(桔梗) 추출물 및 플라티코딘 D(Platycodin D)를 유효성분으로 함유하는 COVID-19의 예방 및 치료용 약학 조성물에 관한 것으로, 보다 상세하게는 길경에 함유된 성분인 플라티코딘 D의 코로나 바이러스 19에 대한 세포 감염 억제 및 세포 내 감염성 바이러스의 생산 저해를 통한 COVID-19의 예방 및 치료용 약학 조성물 및 상기 약학 조성물을 이용한 COVID-19의 예방 및 치료방법에 관한 것으로, 본 발명의 길경 추출물 또는 이의 유효성분인 플라티코딘 D는 코로나 바이러스의 세포 진입 및 세포 감염에 대해 현저한 억제 효과를 나타내며, 코로나 바이러스의 세포 진입 및 세포 감염의 억제를 통한 치료 후보 물질인 클로로퀸 (Chloroquine), 카모스타트(Camostat), 나파모스타트 (Nafamostat)보다 현저한 효과를 나타냄을 확인하였다. 이를 통해, 코로나 바이러스를 예방하거나, 감염 초기 단계의 치료에 유용하게 사용될 수 있다. 또한, 상기 길경 추출물 또는 플라티코딘 D는 코로나바이스의 패키징 시 감염에 중요한 스파이크 단백질의 절단을 억제함으로써, 세포 내 감염성 코로나 바이러스의 증식 및 확산을 억제하는 효과를 나타낸다. 따라서, 본 발명의 조성믈은 코로나 바이러스의 예방 및 치료에 유용하다.</description><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzr0KwkAQBOA0FqK-w4K1EGOjpUhEsBGxD8tlkxxcbo-9Nei7-LCeP4Wl1cAwfMw4e5AfyHGgGgYr10gRTh1Kj4auag06MNwHjlYte2hYQDuCIDSQf1foa1Ah1D4VwA2UH9D9iC9CbLS-BUXrX3lyqHfDdRJaSYZtHKcxCLMC3VTQaJxmowZdpNk3J9l8X152hwUFriiGdNKTVsdzkRdFni_Xm-Vmu_pv9QSbelb-</recordid><startdate>20220215</startdate><enddate>20220215</enddate><creator>LEE C.JUSTIN</creator><creator>KIM TAI YOUNG</creator><scope>EVB</scope></search><sort><creationdate>20220215</creationdate><title>enveloped viruses Pharmaceutical composition for the prevention and treatment of Envelopled viruses comprising taining Platycodon grandiflorus root extracts</title><author>LEE C.JUSTIN ; KIM TAI YOUNG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20220018919A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2022</creationdate><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><toplevel>online_resources</toplevel><creatorcontrib>LEE C.JUSTIN</creatorcontrib><creatorcontrib>KIM TAI YOUNG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEE C.JUSTIN</au><au>KIM TAI YOUNG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>enveloped viruses Pharmaceutical composition for the prevention and treatment of Envelopled viruses comprising taining Platycodon grandiflorus root extracts</title><date>2022-02-15</date><risdate>2022</risdate><abstract>The present invention relates to a pharmaceutical composition for the prevention and treatment of COVID-19 containing a Platycodon grandiflorum extract and platycodin D as active components. More specifically, the present invention relates to a pharmaceutical composition for prevention and treatment of COVID-19 by inhibiting cellular infection of COVID-19 and inhibiting the production of intracellular infectious virus of platicodin D, a component contained in Platycodon grandiflorum, and a method for preventing and treating COVID-19 by using the pharmaceutical composition. The Platycodon grandiflorum extract or platycodin D, an active component thereof exhibits a remarkable inhibitory effect on cell entry and cell infection of coronavirus, and is confirmed to exhibit a more pronounced effect than chloroquine, camostat, and nafamostat, which are treatment candidates through inhibition of cell entry and cell infection of coronavirus. Through the same, the pharmaceutical composition can be usefully used to prevent coronavirus or to treat early stages of infection. In addition, the Platycodon grandiflorum extract or platycodin D inhibits the cleavage of the spike protein important for infection during packaging of coronavirus, thereby inhibiting the proliferation and spread of the infectious coronavirus in cells. Therefore, the composition of the present invention is useful for the prevention and treatment of coronavirus.
본 발명은 길경(桔梗) 추출물 및 플라티코딘 D(Platycodin D)를 유효성분으로 함유하는 COVID-19의 예방 및 치료용 약학 조성물에 관한 것으로, 보다 상세하게는 길경에 함유된 성분인 플라티코딘 D의 코로나 바이러스 19에 대한 세포 감염 억제 및 세포 내 감염성 바이러스의 생산 저해를 통한 COVID-19의 예방 및 치료용 약학 조성물 및 상기 약학 조성물을 이용한 COVID-19의 예방 및 치료방법에 관한 것으로, 본 발명의 길경 추출물 또는 이의 유효성분인 플라티코딘 D는 코로나 바이러스의 세포 진입 및 세포 감염에 대해 현저한 억제 효과를 나타내며, 코로나 바이러스의 세포 진입 및 세포 감염의 억제를 통한 치료 후보 물질인 클로로퀸 (Chloroquine), 카모스타트(Camostat), 나파모스타트 (Nafamostat)보다 현저한 효과를 나타냄을 확인하였다. 이를 통해, 코로나 바이러스를 예방하거나, 감염 초기 단계의 치료에 유용하게 사용될 수 있다. 또한, 상기 길경 추출물 또는 플라티코딘 D는 코로나바이스의 패키징 시 감염에 중요한 스파이크 단백질의 절단을 억제함으로써, 세포 내 감염성 코로나 바이러스의 증식 및 확산을 억제하는 효과를 나타낸다. 따라서, 본 발명의 조성믈은 코로나 바이러스의 예방 및 치료에 유용하다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
| title | enveloped viruses Pharmaceutical composition for the prevention and treatment of Envelopled viruses comprising taining Platycodon grandiflorus root extracts |
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