Composition for preventing or treating kidney damage on heavy metal comprising extracts from Dendropanax morbifera
The present invention relates to a composition for preventing or treating kidney damage caused by heavy metals containing an extract of Dendropanax morbifera, a complex extract of Dendropanax morbifera or a complex fermented extract of Dendropanax morbifera as an active ingredient. As a result of in...
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Sprache: | eng ; kor |
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Zusammenfassung: | The present invention relates to a composition for preventing or treating kidney damage caused by heavy metals containing an extract of Dendropanax morbifera, a complex extract of Dendropanax morbifera or a complex fermented extract of Dendropanax morbifera as an active ingredient. As a result of inducing toxicity by treating LLC-PK1 kidney cells with cadmium after pre-treating the cells with the extract of Dendropanax morbifera, the complex extract of Dendropanax morbifera or the complex fermented extract of Dendropanax morbifera, it was confirmed that the pre-treated kidney cells have reduced cytotoxicity and intracellular free radical generation compared to untreated kidney cells. Accordingly, the composition containing the extract of Dendropanax morbifera, the complex extract of Dendropanax morbifera or the complex fermented extract of Dendropanax morbifera as an active ingredient may be provided as a pharmaceutical composition and a health food useful for preventing and treating kidney damage caused by heavy metals by showing the possibility of alleviating kidney damage due to cadmium.
본 발명은 황칠 추출물, 황칠 복합 추출물 또는 황칠 복합 발효 추출물을 유효성분으로 함유하는 중금속에 의한 신장 손상 예방 또는 치료용 조성물에 관한 것으로, 상기 황칠 추출물, 황칠 복합물 또는 황칠 복합 발효물을 선처리한 LLC-PK1 신장세포에 카드뮴을 처리하여 독성을 유도한 결과, 처리되지 않은 신장 세포에 비해 세포독성과 세포 내 활성산소 발생이 감소되는 것을 확인함에 따라, 상기 황칠 추출물, 황칠 복합물 또는 황칠 복합 발효물을 유효성분으로 함유하는 조성물은 카드뮴에 의한 신장 손상 완화 가능성을 나타내어 중금속에 의한 신장 손상 예방 및 치료에 유용한 약학조성물 및 건강식품으로 제공될 수 있다. |
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