벤조티아디아제핀 화합물 및 담즙산 조절제로서의 그의 용도
본 발명은 하기 화학식 (I)의 1,2,5-벤조티아디아제핀 유도체에 관한 것이다. 상기 화합물은 정단 나트륨-의존성 담즙산 수송체(ASBT) 및/또는 간 담즙산 수송(LBAT) 억제 활성을 갖는 담즙산 조절제이다. 본 발명은 또한 상기 화합물을 포함하는 약학 조성물, 그리고 심혈관 질환, 지방산 대사 및 포도당 이용 장애, 위장 질환 및 간 질환의 치료에서의 상기 화합물의 용도에 관한 것이다: TIFFpct00136.tif5477 The invention relates to 1,2,5-benzothiadiazepine derivat...
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| creator | KULKARNI SANTOSH S MATTSSON JAN STARKE INGEMAR GILLBERG PER GOERAN |
| description | 본 발명은 하기 화학식 (I)의 1,2,5-벤조티아디아제핀 유도체에 관한 것이다. 상기 화합물은 정단 나트륨-의존성 담즙산 수송체(ASBT) 및/또는 간 담즙산 수송(LBAT) 억제 활성을 갖는 담즙산 조절제이다. 본 발명은 또한 상기 화합물을 포함하는 약학 조성물, 그리고 심혈관 질환, 지방산 대사 및 포도당 이용 장애, 위장 질환 및 간 질환의 치료에서의 상기 화합물의 용도에 관한 것이다: TIFFpct00136.tif5477
The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases. |
| format | Patent |
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The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.</description><language>kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211019&DB=EPODOC&CC=KR&NR=20210126053A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211019&DB=EPODOC&CC=KR&NR=20210126053A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KULKARNI SANTOSH S</creatorcontrib><creatorcontrib>MATTSSON JAN</creatorcontrib><creatorcontrib>STARKE INGEMAR</creatorcontrib><creatorcontrib>GILLBERG PER GOERAN</creatorcontrib><title>벤조티아디아제핀 화합물 및 담즙산 조절제로서의 그의 용도</title><description>본 발명은 하기 화학식 (I)의 1,2,5-벤조티아디아제핀 유도체에 관한 것이다. 상기 화합물은 정단 나트륨-의존성 담즙산 수송체(ASBT) 및/또는 간 담즙산 수송(LBAT) 억제 활성을 갖는 담즙산 조절제이다. 본 발명은 또한 상기 화합물을 포함하는 약학 조성물, 그리고 심혈관 질환, 지방산 대사 및 포도당 이용 장애, 위장 질환 및 간 질환의 치료에서의 상기 화합물의 용도에 관한 것이다: TIFFpct00136.tif5477
The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAh8vWnJm4Ub3nZveDO15fWUKUDyzYI5b6c2KLydOeXt1JWv1-xReL2hX-F195Y3y2a-adqgAFT9ZkEHUNHrhXPetMx5M3eGwqvtO0DUm1krX_e38DCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSSeO8gIwMjQwNDIzMDU2NHY-JUAQA_IVBX</recordid><startdate>20211019</startdate><enddate>20211019</enddate><creator>KULKARNI SANTOSH S</creator><creator>MATTSSON JAN</creator><creator>STARKE INGEMAR</creator><creator>GILLBERG PER GOERAN</creator><scope>EVB</scope></search><sort><creationdate>20211019</creationdate><title>벤조티아디아제핀 화합물 및 담즙산 조절제로서의 그의 용도</title><author>KULKARNI SANTOSH S ; MATTSSON JAN ; STARKE INGEMAR ; GILLBERG PER GOERAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20210126053A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KULKARNI SANTOSH S</creatorcontrib><creatorcontrib>MATTSSON JAN</creatorcontrib><creatorcontrib>STARKE INGEMAR</creatorcontrib><creatorcontrib>GILLBERG PER GOERAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KULKARNI SANTOSH S</au><au>MATTSSON JAN</au><au>STARKE INGEMAR</au><au>GILLBERG PER GOERAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>벤조티아디아제핀 화합물 및 담즙산 조절제로서의 그의 용도</title><date>2021-10-19</date><risdate>2021</risdate><abstract>본 발명은 하기 화학식 (I)의 1,2,5-벤조티아디아제핀 유도체에 관한 것이다. 상기 화합물은 정단 나트륨-의존성 담즙산 수송체(ASBT) 및/또는 간 담즙산 수송(LBAT) 억제 활성을 갖는 담즙산 조절제이다. 본 발명은 또한 상기 화합물을 포함하는 약학 조성물, 그리고 심혈관 질환, 지방산 대사 및 포도당 이용 장애, 위장 질환 및 간 질환의 치료에서의 상기 화합물의 용도에 관한 것이다: TIFFpct00136.tif5477
The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 벤조티아디아제핀 화합물 및 담즙산 조절제로서의 그의 용도 |
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