HIV 감염된 세포에 대한 선택적 세포독성제로서의 피리미돈 유도체
본 개시내용은 화학식 I의 피리미돈 유도체, 및 HIV 나이브 세포에 대한 세포독성을 동반하지 않으면서 HIV 감염된 GAG-POL 발현 세포를 선택적으로 사멸시키기 위한 그의 용도, 및 HIV에 의한 감염의 치료 또는 예방, 또는 AIDS 또는 AIDS 관련 복합증 (ARC)의 치료, 예방 또는 그의 발병 또는 진행 지연을 위한 그의 용도에 관한 것이다. TIFFpct00151.tif3553 The present disclosure is directed to pyrimidone derivatives of Formula I and...
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| creator | MITCHELL HELEN J FORSTER ASHLEY NANTERMET PHILIPPE WANG CHENG WANG DEPING FRIE JESSICA L SHA DEYOU SHIPE WILLIAM DANIEL CONVERSO ANTONELLA KUDUK SCOTT D EL MARROUNI ABDELLATIF HUNTER DAVID N |
| description | 본 개시내용은 화학식 I의 피리미돈 유도체, 및 HIV 나이브 세포에 대한 세포독성을 동반하지 않으면서 HIV 감염된 GAG-POL 발현 세포를 선택적으로 사멸시키기 위한 그의 용도, 및 HIV에 의한 감염의 치료 또는 예방, 또는 AIDS 또는 AIDS 관련 복합증 (ARC)의 치료, 예방 또는 그의 발병 또는 진행 지연을 위한 그의 용도에 관한 것이다. TIFFpct00151.tif3553
The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC). |
| format | Patent |
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The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).</description><language>kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210825&DB=EPODOC&CC=KR&NR=20210104796A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210825&DB=EPODOC&CC=KR&NR=20210104796A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MITCHELL HELEN J</creatorcontrib><creatorcontrib>FORSTER ASHLEY</creatorcontrib><creatorcontrib>NANTERMET PHILIPPE</creatorcontrib><creatorcontrib>WANG CHENG</creatorcontrib><creatorcontrib>WANG DEPING</creatorcontrib><creatorcontrib>FRIE JESSICA L</creatorcontrib><creatorcontrib>SHA DEYOU</creatorcontrib><creatorcontrib>SHIPE WILLIAM DANIEL</creatorcontrib><creatorcontrib>CONVERSO ANTONELLA</creatorcontrib><creatorcontrib>KUDUK SCOTT D</creatorcontrib><creatorcontrib>EL MARROUNI ABDELLATIF</creatorcontrib><creatorcontrib>HUNTER DAVID N</creatorcontrib><title>HIV 감염된 세포에 대한 선택적 세포독성제로서의 피리미돈 유도체</title><description>본 개시내용은 화학식 I의 피리미돈 유도체, 및 HIV 나이브 세포에 대한 세포독성을 동반하지 않으면서 HIV 감염된 GAG-POL 발현 세포를 선택적으로 사멸시키기 위한 그의 용도, 및 HIV에 의한 감염의 치료 또는 예방, 또는 AIDS 또는 AIDS 관련 복합증 (ARC)의 치료, 예방 또는 그의 발병 또는 진행 지연을 위한 그의 용도에 관한 것이다. TIFFpct00151.tif3553
The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIjw8AxTeLVhwpvpe15PmKPwpmXH2_41b6ZPUHjd0_B2KkhgwdvmuW8WNEKlXve3vmnZ-GbBnNcL57xpmfNm7gyFt1P2vF625vX6Ha_7OxTezFnwur_lzaYtPAysaYk5xam8UJqbQdnNNcTZQze1ID8-tbggMTk1L7Uk3jvIyMDI0MDQwMTc0szRmDhVAAl8Uzc</recordid><startdate>20210825</startdate><enddate>20210825</enddate><creator>MITCHELL HELEN J</creator><creator>FORSTER ASHLEY</creator><creator>NANTERMET PHILIPPE</creator><creator>WANG CHENG</creator><creator>WANG DEPING</creator><creator>FRIE JESSICA L</creator><creator>SHA DEYOU</creator><creator>SHIPE WILLIAM DANIEL</creator><creator>CONVERSO ANTONELLA</creator><creator>KUDUK SCOTT D</creator><creator>EL MARROUNI ABDELLATIF</creator><creator>HUNTER DAVID N</creator><scope>EVB</scope></search><sort><creationdate>20210825</creationdate><title>HIV 감염된 세포에 대한 선택적 세포독성제로서의 피리미돈 유도체</title><author>MITCHELL HELEN J ; FORSTER ASHLEY ; NANTERMET PHILIPPE ; WANG CHENG ; WANG DEPING ; FRIE JESSICA L ; SHA DEYOU ; SHIPE WILLIAM DANIEL ; CONVERSO ANTONELLA ; KUDUK SCOTT D ; EL MARROUNI ABDELLATIF ; HUNTER DAVID N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20210104796A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MITCHELL HELEN J</creatorcontrib><creatorcontrib>FORSTER ASHLEY</creatorcontrib><creatorcontrib>NANTERMET PHILIPPE</creatorcontrib><creatorcontrib>WANG CHENG</creatorcontrib><creatorcontrib>WANG DEPING</creatorcontrib><creatorcontrib>FRIE JESSICA L</creatorcontrib><creatorcontrib>SHA DEYOU</creatorcontrib><creatorcontrib>SHIPE WILLIAM DANIEL</creatorcontrib><creatorcontrib>CONVERSO ANTONELLA</creatorcontrib><creatorcontrib>KUDUK SCOTT D</creatorcontrib><creatorcontrib>EL MARROUNI ABDELLATIF</creatorcontrib><creatorcontrib>HUNTER DAVID N</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MITCHELL HELEN J</au><au>FORSTER ASHLEY</au><au>NANTERMET PHILIPPE</au><au>WANG CHENG</au><au>WANG DEPING</au><au>FRIE JESSICA L</au><au>SHA DEYOU</au><au>SHIPE WILLIAM DANIEL</au><au>CONVERSO ANTONELLA</au><au>KUDUK SCOTT D</au><au>EL MARROUNI ABDELLATIF</au><au>HUNTER DAVID N</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HIV 감염된 세포에 대한 선택적 세포독성제로서의 피리미돈 유도체</title><date>2021-08-25</date><risdate>2021</risdate><abstract>본 개시내용은 화학식 I의 피리미돈 유도체, 및 HIV 나이브 세포에 대한 세포독성을 동반하지 않으면서 HIV 감염된 GAG-POL 발현 세포를 선택적으로 사멸시키기 위한 그의 용도, 및 HIV에 의한 감염의 치료 또는 예방, 또는 AIDS 또는 AIDS 관련 복합증 (ARC)의 치료, 예방 또는 그의 발병 또는 진행 지연을 위한 그의 용도에 관한 것이다. TIFFpct00151.tif3553
The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HIV 감염된 세포에 대한 선택적 세포독성제로서의 피리미돈 유도체 |
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