Z-N'-2--3--2-4--34H- Novel Z-N'-2-oxoindolin-3-ylidene-2-4-oxoquinazolin-34H-ylacetohydrazides and an anticancer composition comprising the same as an active ingredient
The present invention relates to (Z)-N'-(2-oxoindolin-3-ylidene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide and an anticancer agent composition comprising the same as an active component. Specifically, (Z)-N'-(2-oxoindolin-3-ylidene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide according to...
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| creator | KIM YOUNG SOO PARK EUN JAE NGUYEN HAI NAM DAO THI KIM OANH HONG JIN TAE HAN SANG BAE |
| description | The present invention relates to (Z)-N'-(2-oxoindolin-3-ylidene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide and an anticancer agent composition comprising the same as an active component. Specifically, (Z)-N'-(2-oxoindolin-3-ylidene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide according to the present invention promotes conversion to caspase-3 by activating procaspase-3, thereby being able to be used as a proliferation inhibitor for various cancer cells. A compound according to the present invention can be developed as an active component of a powerful anticancer agent.
본 발명은 (Z)-N'-(2-옥소인돌린-3-일리덴)-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드 및 이를 유효성분으로 포함하는 항암제 조성물에 관한 것이다. 구체적으로, 본 발명에 따른 (Z)-N'-(2-옥소인돌린-3-일리덴)-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드는 프로카스파제-3를 활성화하여 카스파제-3으로의 전환을 촉진하므로, 다양한 암세포에 대한 증식억제제로 사용될 수 있다. 본 발명에 따른 화합물은 강력한 항암제의 활성성분으로서 개발될 수 있을 것으로 기대된다. |
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본 발명은 (Z)-N'-(2-옥소인돌린-3-일리덴)-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드 및 이를 유효성분으로 포함하는 항암제 조성물에 관한 것이다. 구체적으로, 본 발명에 따른 (Z)-N'-(2-옥소인돌린-3-일리덴)-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드는 프로카스파제-3를 활성화하여 카스파제-3으로의 전환을 촉진하므로, 다양한 암세포에 대한 증식억제제로 사용될 수 있다. 본 발명에 따른 화합물은 강력한 항암제의 활성성분으로서 개발될 수 있을 것으로 기대된다.</description><language>eng ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210511&DB=EPODOC&CC=KR&NR=20210052646A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210511&DB=EPODOC&CC=KR&NR=20210052646A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM YOUNG SOO</creatorcontrib><creatorcontrib>PARK EUN JAE</creatorcontrib><creatorcontrib>NGUYEN HAI NAM</creatorcontrib><creatorcontrib>DAO THI KIM OANH</creatorcontrib><creatorcontrib>HONG JIN TAE</creatorcontrib><creatorcontrib>HAN SANG BAE</creatorcontrib><title>Z-N'-2--3--2-4--34H- Novel Z-N'-2-oxoindolin-3-ylidene-2-4-oxoquinazolin-34H-ylacetohydrazides and an anticancer composition comprising the same as an active ingredient</title><description>The present invention relates to (Z)-N'-(2-oxoindolin-3-ylidene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide and an anticancer agent composition comprising the same as an active component. Specifically, (Z)-N'-(2-oxoindolin-3-ylidene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide according to the present invention promotes conversion to caspase-3 by activating procaspase-3, thereby being able to be used as a proliferation inhibitor for various cancer cells. A compound according to the present invention can be developed as an active component of a powerful anticancer agent.
본 발명은 (Z)-N'-(2-옥소인돌린-3-일리덴)-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드 및 이를 유효성분으로 포함하는 항암제 조성물에 관한 것이다. 구체적으로, 본 발명에 따른 (Z)-N'-(2-옥소인돌린-3-일리덴)-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드는 프로카스파제-3를 활성화하여 카스파제-3으로의 전환을 촉진하므로, 다양한 암세포에 대한 증식억제제로 사용될 수 있다. 본 발명에 따른 화합물은 강력한 항암제의 활성성분으로서 개발될 수 있을 것으로 기대된다.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjU0KwjAQRrtxIeodAi5cBWpb3YsoguBCXLkpIRl1IM7UJortiTymQ-0BhPmD9z5mmHzO-jDTmda5llnILnZaHfgFXvWI34zk2COJ1Hh0QNC5Ah5PJNP-mAQbbyxEvjWuNq2IQRly0lIRrSELtbJ8rzhgRKburjEgXVW8gQrmDsqELmAjvkAJqcEhUBwng4vxASb9HiXT7ea03mmouIRQyWOCWO6PWZrN03SRLYvlKv_P-gLqL1RK</recordid><startdate>20210511</startdate><enddate>20210511</enddate><creator>KIM YOUNG SOO</creator><creator>PARK EUN JAE</creator><creator>NGUYEN HAI NAM</creator><creator>DAO THI KIM OANH</creator><creator>HONG JIN TAE</creator><creator>HAN SANG BAE</creator><scope>EVB</scope></search><sort><creationdate>20210511</creationdate><title>Z-N'-2--3--2-4--34H- Novel Z-N'-2-oxoindolin-3-ylidene-2-4-oxoquinazolin-34H-ylacetohydrazides and an anticancer composition comprising the same as an active ingredient</title><author>KIM YOUNG SOO ; PARK EUN JAE ; NGUYEN HAI NAM ; DAO THI KIM OANH ; HONG JIN TAE ; HAN SANG BAE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20210052646A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM YOUNG SOO</creatorcontrib><creatorcontrib>PARK EUN JAE</creatorcontrib><creatorcontrib>NGUYEN HAI NAM</creatorcontrib><creatorcontrib>DAO THI KIM OANH</creatorcontrib><creatorcontrib>HONG JIN TAE</creatorcontrib><creatorcontrib>HAN SANG BAE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM YOUNG SOO</au><au>PARK EUN JAE</au><au>NGUYEN HAI NAM</au><au>DAO THI KIM OANH</au><au>HONG JIN TAE</au><au>HAN SANG BAE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Z-N'-2--3--2-4--34H- Novel Z-N'-2-oxoindolin-3-ylidene-2-4-oxoquinazolin-34H-ylacetohydrazides and an anticancer composition comprising the same as an active ingredient</title><date>2021-05-11</date><risdate>2021</risdate><abstract>The present invention relates to (Z)-N'-(2-oxoindolin-3-ylidene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide and an anticancer agent composition comprising the same as an active component. Specifically, (Z)-N'-(2-oxoindolin-3-ylidene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide according to the present invention promotes conversion to caspase-3 by activating procaspase-3, thereby being able to be used as a proliferation inhibitor for various cancer cells. A compound according to the present invention can be developed as an active component of a powerful anticancer agent.
본 발명은 (Z)-N'-(2-옥소인돌린-3-일리덴)-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드 및 이를 유효성분으로 포함하는 항암제 조성물에 관한 것이다. 구체적으로, 본 발명에 따른 (Z)-N'-(2-옥소인돌린-3-일리덴)-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드는 프로카스파제-3를 활성화하여 카스파제-3으로의 전환을 촉진하므로, 다양한 암세포에 대한 증식억제제로 사용될 수 있다. 본 발명에 따른 화합물은 강력한 항암제의 활성성분으로서 개발될 수 있을 것으로 기대된다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Z-N'-2--3--2-4--34H- Novel Z-N'-2-oxoindolin-3-ylidene-2-4-oxoquinazolin-34H-ylacetohydrazides and an anticancer composition comprising the same as an active ingredient |
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