간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물
본 발명은 HLA-A2를 발현하는 간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 세포 표면에 HLA-A2를 발현하는 간엽줄기세포는 염증성 사이토카인인 TNF-α의 분비를 억제하고, 항염증성 마커인 CD163과 Arg-1의 발현을 증가시키므로, 상기 간엽줄기세포를 유효성분으로 포함하는 약학 조성물은 염증을 억제하거나, 염증 질환을 치료하는데 유용하게 사용될 수 있다. The present invention relates to a pharmaceutical compositi...
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| creator | LIM HOON YANG YUN SUN OH WONIL CHOI SOO JIN KWAK JIHYE KIM DONG HYON |
| description | 본 발명은 HLA-A2를 발현하는 간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 세포 표면에 HLA-A2를 발현하는 간엽줄기세포는 염증성 사이토카인인 TNF-α의 분비를 억제하고, 항염증성 마커인 CD163과 Arg-1의 발현을 증가시키므로, 상기 간엽줄기세포를 유효성분으로 포함하는 약학 조성물은 염증을 억제하거나, 염증 질환을 치료하는데 유용하게 사용될 수 있다.
The present invention relates to a pharmaceutical composition comprising hyaluronic acid and mesenchymal stem cells for treating cartilage damage-associated diseases. Compared to when hyaluronic acid and mesenchymal stem cells are administered as a mixture, administering mesenchymal stem cells after first administering hyaluronic acid, according to the present invention, may exhibit superior effects in alleviating disease symptoms in joint tissues affected by arthritis and also decrease the load on knees due to body weight. Accordingly, the pharmaceutical composition of the present invention may be beneficially used in the treatment of cartilage damage-associated diseases. |
| format | Patent |
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The present invention relates to a pharmaceutical composition comprising hyaluronic acid and mesenchymal stem cells for treating cartilage damage-associated diseases. Compared to when hyaluronic acid and mesenchymal stem cells are administered as a mixture, administering mesenchymal stem cells after first administering hyaluronic acid, according to the present invention, may exhibit superior effects in alleviating disease symptoms in joint tissues affected by arthritis and also decrease the load on knees due to body weight. Accordingly, the pharmaceutical composition of the present invention may be beneficially used in the treatment of cartilage damage-associated diseases.</description><language>kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210125&DB=EPODOC&CC=KR&NR=20210008873A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210125&DB=EPODOC&CC=KR&NR=20210008873A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIM HOON</creatorcontrib><creatorcontrib>YANG YUN SUN</creatorcontrib><creatorcontrib>OH WONIL</creatorcontrib><creatorcontrib>CHOI SOO JIN</creatorcontrib><creatorcontrib>KWAK JIHYE</creatorcontrib><creatorcontrib>KIM DONG HYON</creatorcontrib><title>간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물</title><description>본 발명은 HLA-A2를 발현하는 간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 세포 표면에 HLA-A2를 발현하는 간엽줄기세포는 염증성 사이토카인인 TNF-α의 분비를 억제하고, 항염증성 마커인 CD163과 Arg-1의 발현을 증가시키므로, 상기 간엽줄기세포를 유효성분으로 포함하는 약학 조성물은 염증을 억제하거나, 염증 질환을 치료하는데 유용하게 사용될 수 있다.
The present invention relates to a pharmaceutical composition comprising hyaluronic acid and mesenchymal stem cells for treating cartilage damage-associated diseases. Compared to when hyaluronic acid and mesenchymal stem cells are administered as a mixture, administering mesenchymal stem cells after first administering hyaluronic acid, according to the present invention, may exhibit superior effects in alleviating disease symptoms in joint tissues affected by arthritis and also decrease the load on knees due to body weight. Accordingly, the pharmaceutical composition of the present invention may be beneficially used in the treatment of cartilage damage-associated diseases.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZMh5taHlzfS9b5a0vNqx4U3Ljrf9a14v3aPwZs6Ct7NWvGnZ-Hpby5s5e14vnKMAlHk7dcXbqTNed01ReDN9z5tlcxXeLO94O3OGwpsZHa83rFR4PWMCWG7njNeLe97MWqnwZuret1NnKrxZuAFk0po9PAysaYk5xam8UJqbQdnNNcTZQze1ID8-tbggMTk1L7Uk3jvIyMDI0MDAwMLC3NjRmDhVAN2vYs4</recordid><startdate>20210125</startdate><enddate>20210125</enddate><creator>LIM HOON</creator><creator>YANG YUN SUN</creator><creator>OH WONIL</creator><creator>CHOI SOO JIN</creator><creator>KWAK JIHYE</creator><creator>KIM DONG HYON</creator><scope>EVB</scope></search><sort><creationdate>20210125</creationdate><title>간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물</title><author>LIM HOON ; YANG YUN SUN ; OH WONIL ; CHOI SOO JIN ; KWAK JIHYE ; KIM DONG HYON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20210008873A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIM HOON</creatorcontrib><creatorcontrib>YANG YUN SUN</creatorcontrib><creatorcontrib>OH WONIL</creatorcontrib><creatorcontrib>CHOI SOO JIN</creatorcontrib><creatorcontrib>KWAK JIHYE</creatorcontrib><creatorcontrib>KIM DONG HYON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIM HOON</au><au>YANG YUN SUN</au><au>OH WONIL</au><au>CHOI SOO JIN</au><au>KWAK JIHYE</au><au>KIM DONG HYON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물</title><date>2021-01-25</date><risdate>2021</risdate><abstract>본 발명은 HLA-A2를 발현하는 간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 세포 표면에 HLA-A2를 발현하는 간엽줄기세포는 염증성 사이토카인인 TNF-α의 분비를 억제하고, 항염증성 마커인 CD163과 Arg-1의 발현을 증가시키므로, 상기 간엽줄기세포를 유효성분으로 포함하는 약학 조성물은 염증을 억제하거나, 염증 질환을 치료하는데 유용하게 사용될 수 있다.
The present invention relates to a pharmaceutical composition comprising hyaluronic acid and mesenchymal stem cells for treating cartilage damage-associated diseases. Compared to when hyaluronic acid and mesenchymal stem cells are administered as a mixture, administering mesenchymal stem cells after first administering hyaluronic acid, according to the present invention, may exhibit superior effects in alleviating disease symptoms in joint tissues affected by arthritis and also decrease the load on knees due to body weight. Accordingly, the pharmaceutical composition of the present invention may be beneficially used in the treatment of cartilage damage-associated diseases.</abstract><oa>free_for_read</oa></addata></record> |
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| title | 간엽줄기세포를 유효성분으로 포함하는 염증 질환 예방 또는 치료용 약학 조성물 |
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