세레블론 개질 화합물을 스크리닝하는 방법
샘플을 얻는 단계; SALL4의 제1 단백질 수준을 결정하는 단계; 세레블론 개질 화합물을 샘플에 투여하는 단계; SALL4의 제2 단백질 수준을 결정하는 단계; SALL4의 제1 수준과 제2 단백질 수준을 비교하여 세레블론 개질 화합물이 SALL4의 분해를 유도하는지 여부를 결정하는 단계; 및 SALL4의 분해를 유도하지 않는 세레블론 개질 화합물을 선택하는 단계를 포함하는, 질환 또는 장애를 치료하기 위한 세레블론 개질 화합물을 스크리닝하는 방법. A method of screening a cereblon modifying co...
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| creator | CHAMBERLAIN PHILIP MATYSKIELA MARY SHERRATT PHILIP J COUTO SUZANA STURLINI LU GANG HUI JULIA STAMP KATHERINE |
| description | 샘플을 얻는 단계; SALL4의 제1 단백질 수준을 결정하는 단계; 세레블론 개질 화합물을 샘플에 투여하는 단계; SALL4의 제2 단백질 수준을 결정하는 단계; SALL4의 제1 수준과 제2 단백질 수준을 비교하여 세레블론 개질 화합물이 SALL4의 분해를 유도하는지 여부를 결정하는 단계; 및 SALL4의 분해를 유도하지 않는 세레블론 개질 화합물을 선택하는 단계를 포함하는, 질환 또는 장애를 치료하기 위한 세레블론 개질 화합물을 스크리닝하는 방법.
A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4. |
| format | Patent |
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A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.</description><language>kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200918&DB=EPODOC&CC=KR&NR=20200108427A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200918&DB=EPODOC&CC=KR&NR=20200108427A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAMBERLAIN PHILIP</creatorcontrib><creatorcontrib>MATYSKIELA MARY</creatorcontrib><creatorcontrib>SHERRATT PHILIP J</creatorcontrib><creatorcontrib>COUTO SUZANA STURLINI</creatorcontrib><creatorcontrib>LU GANG</creatorcontrib><creatorcontrib>HUI JULIA</creatorcontrib><creatorcontrib>STAMP KATHERINE</creatorcontrib><title>세레블론 개질 화합물을 스크리닝하는 방법</title><description>샘플을 얻는 단계; SALL4의 제1 단백질 수준을 결정하는 단계; 세레블론 개질 화합물을 샘플에 투여하는 단계; SALL4의 제2 단백질 수준을 결정하는 단계; SALL4의 제1 수준과 제2 단백질 수준을 비교하여 세레블론 개질 화합물이 SALL4의 분해를 유도하는지 여부를 결정하는 단계; 및 SALL4의 분해를 유도하지 않는 세레블론 개질 화합물을 선택하는 단계를 포함하는, 질환 또는 장애를 치료하기 위한 세레블론 개질 화합물을 스크리닝하는 방법.
A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB607Lj9YKO1zumvF64QOHVhjlvlncovJ055e3Ula_X7Hkzt0XhTdeSt41rXi9b87p77tupM153TVF4vWHl601TeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJvHeQkYGRgYGhgYWJkbmjMXGqAGwrQSI</recordid><startdate>20200918</startdate><enddate>20200918</enddate><creator>CHAMBERLAIN PHILIP</creator><creator>MATYSKIELA MARY</creator><creator>SHERRATT PHILIP J</creator><creator>COUTO SUZANA STURLINI</creator><creator>LU GANG</creator><creator>HUI JULIA</creator><creator>STAMP KATHERINE</creator><scope>EVB</scope></search><sort><creationdate>20200918</creationdate><title>세레블론 개질 화합물을 스크리닝하는 방법</title><author>CHAMBERLAIN PHILIP ; MATYSKIELA MARY ; SHERRATT PHILIP J ; COUTO SUZANA STURLINI ; LU GANG ; HUI JULIA ; STAMP KATHERINE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20200108427A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHAMBERLAIN PHILIP</creatorcontrib><creatorcontrib>MATYSKIELA MARY</creatorcontrib><creatorcontrib>SHERRATT PHILIP J</creatorcontrib><creatorcontrib>COUTO SUZANA STURLINI</creatorcontrib><creatorcontrib>LU GANG</creatorcontrib><creatorcontrib>HUI JULIA</creatorcontrib><creatorcontrib>STAMP KATHERINE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHAMBERLAIN PHILIP</au><au>MATYSKIELA MARY</au><au>SHERRATT PHILIP J</au><au>COUTO SUZANA STURLINI</au><au>LU GANG</au><au>HUI JULIA</au><au>STAMP KATHERINE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>세레블론 개질 화합물을 스크리닝하는 방법</title><date>2020-09-18</date><risdate>2020</risdate><abstract>샘플을 얻는 단계; SALL4의 제1 단백질 수준을 결정하는 단계; 세레블론 개질 화합물을 샘플에 투여하는 단계; SALL4의 제2 단백질 수준을 결정하는 단계; SALL4의 제1 수준과 제2 단백질 수준을 비교하여 세레블론 개질 화합물이 SALL4의 분해를 유도하는지 여부를 결정하는 단계; 및 SALL4의 분해를 유도하지 않는 세레블론 개질 화합물을 선택하는 단계를 포함하는, 질환 또는 장애를 치료하기 위한 세레블론 개질 화합물을 스크리닝하는 방법.
A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | 세레블론 개질 화합물을 스크리닝하는 방법 |
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