PCA METHOD FOR PRECIPITATION OF CULTURE FLUID USING PCA PROCESS

PCA 공정을 이용한 배양액의 결정화 방법이 제공된다. 상기 PCA 공정을 이용한 배양액의 결정화 방법은, 용기에 제1 용매 및 상기 제1 용매에 녹아있는 타겟 물질을 포함하는 배양액을 공급하는 단계, 상기 용기에 제3 용매를 공급하는 단계, 및 상기 용기에 제2 용매를 공급하는 단계를 포함한다. 상기 제1 내지 제3 용매는 다성분계 혼합물을 생성하고, 상기 타겟 물질은 석출된다. Provided are an apparatus and method for crystallizing a culture solution using a PCA process. The method for crystallizing a culture solution using a PCA process comprises the steps of: supplying, to a container, a culture solution including a first solvent and a target material dissolved in the first solvent; supplying a third solvent to the container; and supplying a second solvent to the container. The first to third solvents form a multi-component mixture, and the target material precipitates. The apparatus for crystallizing a culture solution using a PCA process is an apparatus for acquiring a target material by drying a culture solution including a first solvent and the target material being dissolved in the first solvent, the apparatus comprising: a high-pressure container to which the culture solution is supplied; a first supply unit which is connected to the high-pressure container and supplies a second solvent to the high-pressure container; a second supply unit which is connected to the high-pressure container and supplies a third solvent; a pre-cooler which is provided adjacent to the first supply unit and pre-cools the second solvent discharged from the first supply unit; and a pre-heater which is provided adjacent to the high-pressure container and pre-heats the second solvent supplied to the high-pressure container.