MUC17 및 CD3에 대한 이중특이적 항체 구축물
본 발명은 MUC17에 결합하는 제1 도메인, 인간 및 마카카의 CD3ε 쇄의 세포 외 에피토프에 결합하는 제2 도메인 및 선택적으로 특이적 Fc 모달리티인 제3 도메인을 포함하는 것을 특징으로 하는 이중특이적 항체 구축물을 제공한다. 게다가, 본 발명은 항체 구축물을 암호화하는 폴리뉴클레오티드, 이 폴리뉴클레오티드를 포함하는 벡터, 구축물을 발현시키는 숙주 세포 및 이들을 포함하는 약제학적 조성물을 제공한다. The present invention provides bispecific antibody constructs charac...
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| creator | WAHI JOACHIM RAUM TOBIAS BAILIS JULIE ARVEDSON TARA ROSS SANDRA PENDZIALEK JOCHEN BLUEMEL CLAUDIA DAHLHOFF CHRISTOPH NAHRWOLD ELISABETH CHEN IRWIN |
| description | 본 발명은 MUC17에 결합하는 제1 도메인, 인간 및 마카카의 CD3ε 쇄의 세포 외 에피토프에 결합하는 제2 도메인 및 선택적으로 특이적 Fc 모달리티인 제3 도메인을 포함하는 것을 특징으로 하는 이중특이적 항체 구축물을 제공한다. 게다가, 본 발명은 항체 구축물을 암호화하는 폴리뉴클레오티드, 이 폴리뉴클레오티드를 포함하는 벡터, 구축물을 발현시키는 숙주 세포 및 이들을 포함하는 약제학적 조성물을 제공한다.
The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same. |
| format | Patent |
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The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.</description><language>kor</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200907&DB=EPODOC&CC=KR&NR=20200105493A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200907&DB=EPODOC&CC=KR&NR=20200105493A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WAHI JOACHIM</creatorcontrib><creatorcontrib>RAUM TOBIAS</creatorcontrib><creatorcontrib>BAILIS JULIE</creatorcontrib><creatorcontrib>ARVEDSON TARA</creatorcontrib><creatorcontrib>ROSS SANDRA</creatorcontrib><creatorcontrib>PENDZIALEK JOCHEN</creatorcontrib><creatorcontrib>BLUEMEL CLAUDIA</creatorcontrib><creatorcontrib>DAHLHOFF CHRISTOPH</creatorcontrib><creatorcontrib>NAHRWOLD ELISABETH</creatorcontrib><creatorcontrib>CHEN IRWIN</creatorcontrib><title>MUC17 및 CD3에 대한 이중특이적 항체 구축물</title><description>본 발명은 MUC17에 결합하는 제1 도메인, 인간 및 마카카의 CD3ε 쇄의 세포 외 에피토프에 결합하는 제2 도메인 및 선택적으로 특이적 Fc 모달리티인 제3 도메인을 포함하는 것을 특징으로 하는 이중특이적 항체 구축물을 제공한다. 게다가, 본 발명은 항체 구축물을 암호화하는 폴리뉴클레오티드, 이 폴리뉴클레오티드를 포함하는 벡터, 구축물을 발현시키는 숙주 세포 및 이들을 포함하는 약제학적 조성물을 제공한다.
The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDwDXU2NFd4vaFfwdnF-M30CQqvexreTp2j8GbuljdLJr7t2gliLGhUeDt17ZtNWxRebV3zZtvU12v28DCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSSeO8gIwMjAwNDA1MTS2NHY-JUAQAItjs2</recordid><startdate>20200907</startdate><enddate>20200907</enddate><creator>WAHI JOACHIM</creator><creator>RAUM TOBIAS</creator><creator>BAILIS JULIE</creator><creator>ARVEDSON TARA</creator><creator>ROSS SANDRA</creator><creator>PENDZIALEK JOCHEN</creator><creator>BLUEMEL CLAUDIA</creator><creator>DAHLHOFF CHRISTOPH</creator><creator>NAHRWOLD ELISABETH</creator><creator>CHEN IRWIN</creator><scope>EVB</scope></search><sort><creationdate>20200907</creationdate><title>MUC17 및 CD3에 대한 이중특이적 항체 구축물</title><author>WAHI JOACHIM ; RAUM TOBIAS ; BAILIS JULIE ; ARVEDSON TARA ; ROSS SANDRA ; PENDZIALEK JOCHEN ; BLUEMEL CLAUDIA ; DAHLHOFF CHRISTOPH ; NAHRWOLD ELISABETH ; CHEN IRWIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20200105493A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WAHI JOACHIM</creatorcontrib><creatorcontrib>RAUM TOBIAS</creatorcontrib><creatorcontrib>BAILIS JULIE</creatorcontrib><creatorcontrib>ARVEDSON TARA</creatorcontrib><creatorcontrib>ROSS SANDRA</creatorcontrib><creatorcontrib>PENDZIALEK JOCHEN</creatorcontrib><creatorcontrib>BLUEMEL CLAUDIA</creatorcontrib><creatorcontrib>DAHLHOFF CHRISTOPH</creatorcontrib><creatorcontrib>NAHRWOLD ELISABETH</creatorcontrib><creatorcontrib>CHEN IRWIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WAHI JOACHIM</au><au>RAUM TOBIAS</au><au>BAILIS JULIE</au><au>ARVEDSON TARA</au><au>ROSS SANDRA</au><au>PENDZIALEK JOCHEN</au><au>BLUEMEL CLAUDIA</au><au>DAHLHOFF CHRISTOPH</au><au>NAHRWOLD ELISABETH</au><au>CHEN IRWIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MUC17 및 CD3에 대한 이중특이적 항체 구축물</title><date>2020-09-07</date><risdate>2020</risdate><abstract>본 발명은 MUC17에 결합하는 제1 도메인, 인간 및 마카카의 CD3ε 쇄의 세포 외 에피토프에 결합하는 제2 도메인 및 선택적으로 특이적 Fc 모달리티인 제3 도메인을 포함하는 것을 특징으로 하는 이중특이적 항체 구축물을 제공한다. 게다가, 본 발명은 항체 구축물을 암호화하는 폴리뉴클레오티드, 이 폴리뉴클레오티드를 포함하는 벡터, 구축물을 발현시키는 숙주 세포 및 이들을 포함하는 약제학적 조성물을 제공한다.
The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.</abstract><oa>free_for_read</oa></addata></record> |
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| title | MUC17 및 CD3에 대한 이중특이적 항체 구축물 |
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