Biomarker composition for identification of exposure to humidifier disinfectant component in lung tissue and the method of identification using the same
The present invention relates to a biomarker composition for identifying the exposure to a humidifier disinfectant component in lung tissues, and to an identification method using the same. In the present invention, an analysis of a protein body is performed by using a lung tissue of an acute group...
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| creator | HONG SANG BUM YU JI YOUNG KIM KYUNG GON HONG SOO JONG YEOM JEONG HUN |
| description | The present invention relates to a biomarker composition for identifying the exposure to a humidifier disinfectant component in lung tissues, and to an identification method using the same. In the present invention, an analysis of a protein body is performed by using a lung tissue of an acute group which is exposed to a humidifier disinfectant (within two months after the visit to a hospital due to the occurrence of symptoms) and a lung tissue of a normal control group which is not exposed to the humidifier disinfectant. At the same time, a protein for distinguishing the normal control group and the acute group is sorted, by using a protein representing a specific quantitative change in blood proteins of the acute group and a keeping group (three years after the visit to a hospital due to the occurrence of symptoms). Therefore, the protein can be used as a biomarker composition for identifying the exposure to a humidifier disinfectant component.
본 발명은 폐조직 내 가습기 살균제 성분 노출 여부 확인용 바이오마커 조성물 및 이를 이용한 확인 방법에 관한 것으로, 본 발명에서는 가습기 살균제에 노출된 급성군(증상 발생하여 내원 후 2달 이내)의 폐조직 및 가습기 살균제에 노출되지 않은 정상대조군의 폐조직을 이용하여 단백질체 분석을 수행하였으며, 이와 동시에 급성군 및 유지군(증상 발생하여 내원 후 3년 경과)의 혈액 단백질에서 특이적 양적 변화를 나타내는 단백질을 이용하여 정상대조군 및 급성군을 감별할 수 있는 단백질을 선별한 바, 상기 단백질은 가습기 살균제 성분 노출 여부를 확인용 바이오마커 조성물로 활용될 수 있다. |
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본 발명은 폐조직 내 가습기 살균제 성분 노출 여부 확인용 바이오마커 조성물 및 이를 이용한 확인 방법에 관한 것으로, 본 발명에서는 가습기 살균제에 노출된 급성군(증상 발생하여 내원 후 2달 이내)의 폐조직 및 가습기 살균제에 노출되지 않은 정상대조군의 폐조직을 이용하여 단백질체 분석을 수행하였으며, 이와 동시에 급성군 및 유지군(증상 발생하여 내원 후 3년 경과)의 혈액 단백질에서 특이적 양적 변화를 나타내는 단백질을 이용하여 정상대조군 및 급성군을 감별할 수 있는 단백질을 선별한 바, 상기 단백질은 가습기 살균제 성분 노출 여부를 확인용 바이오마커 조성물로 활용될 수 있다.</description><language>eng ; kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200122&DB=EPODOC&CC=KR&NR=20200007258A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200122&DB=EPODOC&CC=KR&NR=20200007258A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HONG SANG BUM</creatorcontrib><creatorcontrib>YU JI YOUNG</creatorcontrib><creatorcontrib>KIM KYUNG GON</creatorcontrib><creatorcontrib>HONG SOO JONG</creatorcontrib><creatorcontrib>YEOM JEONG HUN</creatorcontrib><title>Biomarker composition for identification of exposure to humidifier disinfectant component in lung tissue and the method of identification using the same</title><description>The present invention relates to a biomarker composition for identifying the exposure to a humidifier disinfectant component in lung tissues, and to an identification method using the same. In the present invention, an analysis of a protein body is performed by using a lung tissue of an acute group which is exposed to a humidifier disinfectant (within two months after the visit to a hospital due to the occurrence of symptoms) and a lung tissue of a normal control group which is not exposed to the humidifier disinfectant. At the same time, a protein for distinguishing the normal control group and the acute group is sorted, by using a protein representing a specific quantitative change in blood proteins of the acute group and a keeping group (three years after the visit to a hospital due to the occurrence of symptoms). Therefore, the protein can be used as a biomarker composition for identifying the exposure to a humidifier disinfectant component.
본 발명은 폐조직 내 가습기 살균제 성분 노출 여부 확인용 바이오마커 조성물 및 이를 이용한 확인 방법에 관한 것으로, 본 발명에서는 가습기 살균제에 노출된 급성군(증상 발생하여 내원 후 2달 이내)의 폐조직 및 가습기 살균제에 노출되지 않은 정상대조군의 폐조직을 이용하여 단백질체 분석을 수행하였으며, 이와 동시에 급성군 및 유지군(증상 발생하여 내원 후 3년 경과)의 혈액 단백질에서 특이적 양적 변화를 나타내는 단백질을 이용하여 정상대조군 및 급성군을 감별할 수 있는 단백질을 선별한 바, 상기 단백질은 가습기 살균제 성분 노출 여부를 확인용 바이오마커 조성물로 활용될 수 있다.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjbEKwkAMhrs4iPoOAWehVERXFUVwE_dy9HI22EvKXQ58FB_Xszo5mSWQ__u_jIvnjsSbcMcAjfheIikJg5MAZJGVHDVmOIkDfGQgBQQVaJMnm9NctBSJHTZqWD8Wzk0ghi7xDZRiTAiGLWiL4FFbsW_dz4OULbcBicbjtBg500WcffekmB8P1_1pgb3UGHvTIKPW50tVVmWedbXabJf_US94yVQj</recordid><startdate>20200122</startdate><enddate>20200122</enddate><creator>HONG SANG BUM</creator><creator>YU JI YOUNG</creator><creator>KIM KYUNG GON</creator><creator>HONG SOO JONG</creator><creator>YEOM JEONG HUN</creator><scope>EVB</scope></search><sort><creationdate>20200122</creationdate><title>Biomarker composition for identification of exposure to humidifier disinfectant component in lung tissue and the method of identification using the same</title><author>HONG SANG BUM ; YU JI YOUNG ; KIM KYUNG GON ; HONG SOO JONG ; YEOM JEONG HUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20200007258A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HONG SANG BUM</creatorcontrib><creatorcontrib>YU JI YOUNG</creatorcontrib><creatorcontrib>KIM KYUNG GON</creatorcontrib><creatorcontrib>HONG SOO JONG</creatorcontrib><creatorcontrib>YEOM JEONG HUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HONG SANG BUM</au><au>YU JI YOUNG</au><au>KIM KYUNG GON</au><au>HONG SOO JONG</au><au>YEOM JEONG HUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Biomarker composition for identification of exposure to humidifier disinfectant component in lung tissue and the method of identification using the same</title><date>2020-01-22</date><risdate>2020</risdate><abstract>The present invention relates to a biomarker composition for identifying the exposure to a humidifier disinfectant component in lung tissues, and to an identification method using the same. In the present invention, an analysis of a protein body is performed by using a lung tissue of an acute group which is exposed to a humidifier disinfectant (within two months after the visit to a hospital due to the occurrence of symptoms) and a lung tissue of a normal control group which is not exposed to the humidifier disinfectant. At the same time, a protein for distinguishing the normal control group and the acute group is sorted, by using a protein representing a specific quantitative change in blood proteins of the acute group and a keeping group (three years after the visit to a hospital due to the occurrence of symptoms). Therefore, the protein can be used as a biomarker composition for identifying the exposure to a humidifier disinfectant component.
본 발명은 폐조직 내 가습기 살균제 성분 노출 여부 확인용 바이오마커 조성물 및 이를 이용한 확인 방법에 관한 것으로, 본 발명에서는 가습기 살균제에 노출된 급성군(증상 발생하여 내원 후 2달 이내)의 폐조직 및 가습기 살균제에 노출되지 않은 정상대조군의 폐조직을 이용하여 단백질체 분석을 수행하였으며, 이와 동시에 급성군 및 유지군(증상 발생하여 내원 후 3년 경과)의 혈액 단백질에서 특이적 양적 변화를 나타내는 단백질을 이용하여 정상대조군 및 급성군을 감별할 수 있는 단백질을 선별한 바, 상기 단백질은 가습기 살균제 성분 노출 여부를 확인용 바이오마커 조성물로 활용될 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE |
| title | Biomarker composition for identification of exposure to humidifier disinfectant component in lung tissue and the method of identification using the same |
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