종양 항원 제시 유도체 작제물 및 그의 용도

항원-제시 세포 (APC) 상에 발현된 ISR에 결합한 적어도 하나 선천성 자극 수용체 (ISR)-결합 작제물, 및 하나 이상의 다른 TAA를 포함하는 종양 세포-유래 물질 (TCDM)과 물리적으로 연결된 제1 TAA에 직접 결합된 적어도 하나 TAA-결합 작제물을 포함하는 종양-관련 항원 (TAA) 제시 유발체 작제물이 본원에서 제공된다. 상기 ISR-결합 작제물 및 상기 TAA-결합 작제물은 서로 연결되고, 상기 TAA 제시 유발체 작제물은 제1 TAA 및 하나 이상의 다른 TAA에 대해 다중 클론 T 세포 반응을 유발한다. 또...

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Hauptverfasser:	MILLS DAVID M, ESCOBAR CABRERA ERIC
Format:	Patent
Sprache:	kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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creator	MILLS DAVID M ESCOBAR CABRERA ERIC
description	항원-제시 세포 (APC) 상에 발현된 ISR에 결합한 적어도 하나 선천성 자극 수용체 (ISR)-결합 작제물, 및 하나 이상의 다른 TAA를 포함하는 종양 세포-유래 물질 (TCDM)과 물리적으로 연결된 제1 TAA에 직접 결합된 적어도 하나 TAA-결합 작제물을 포함하는 종양-관련 항원 (TAA) 제시 유발체 작제물이 본원에서 제공된다. 상기 ISR-결합 작제물 및 상기 TAA-결합 작제물은 서로 연결되고, 상기 TAA 제시 유발체 작제물은 제1 TAA 및 하나 이상의 다른 TAA에 대해 다중 클론 T 세포 반응을 유발한다. 또한, 예를 들어 암 치료에 있어서, 상기 TAA 제시 유발체 작제물을 사용하는 방법도 제공된다. Provided herein are tumor-associated antigen (TAA) presentation inducer constructs comprising at least one innate stimulatory receptor (ISR)-binding construct that binds to an ISR expressed on an antigen-presenting cell (APC), and at least one TAA-binding construct that binds directly to a first TAA that is physically associated with tumor cell-derived material (TCDM) comprising one or more other TAAs. The ISR-binding construct and TAA-binding construct are linked to each other, and the TAA presentation inducer construct induces a polyclonal T cell response to the first TAA and to the one or more other TAAs. Also provided are methods of using the TAA presentation inducer constructs, for example, in the treatment of cancer.
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Provided herein are tumor-associated antigen (TAA) presentation inducer constructs comprising at least one innate stimulatory receptor (ISR)-binding construct that binds to an ISR expressed on an antigen-presenting cell (APC), and at least one TAA-binding construct that binds directly to a first TAA that is physically associated with tumor cell-derived material (TCDM) comprising one or more other TAAs. The ISR-binding construct and TAA-binding construct are linked to each other, and the TAA presentation inducer construct induces a polyclonal T cell response to the first TAA and to the one or more other TAAs. Also provided are methods of using the TAA presentation inducer constructs, for example, in the treatment of cancer.</description><language>kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191205&DB=EPODOC&CC=KR&NR=20190135007A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191205&DB=EPODOC&CC=KR&NR=20190135007A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MILLS DAVID M</creatorcontrib><creatorcontrib>ESCOBAR CABRERA ERIC</creatorcontrib><title>종양 항원 제시 유도체 작제물 및 그의 용도</title><description>항원-제시 세포 (APC) 상에 발현된 ISR에 결합한 적어도 하나 선천성 자극 수용체 (ISR)-결합 작제물, 및 하나 이상의 다른 TAA를 포함하는 종양 세포-유래 물질 (TCDM)과 물리적으로 연결된 제1 TAA에 직접 결합된 적어도 하나 TAA-결합 작제물을 포함하는 종양-관련 항원 (TAA) 제시 유발체 작제물이 본원에서 제공된다. 상기 ISR-결합 작제물 및 상기 TAA-결합 작제물은 서로 연결되고, 상기 TAA 제시 유발체 작제물은 제1 TAA 및 하나 이상의 다른 TAA에 대해 다중 클론 T 세포 반응을 유발한다. 또한, 예를 들어 암 치료에 있어서, 상기 TAA 제시 유발체 작제물을 사용하는 방법도 제공된다. Provided herein are tumor-associated antigen (TAA) presentation inducer constructs comprising at least one innate stimulatory receptor (ISR)-binding construct that binds to an ISR expressed on an antigen-presenting cell (APC), and at least one TAA-binding construct that binds directly to a first TAA that is physically associated with tumor cell-derived material (TCDM) comprising one or more other TAAs. The ISR-binding construct and TAA-binding construct are linked to each other, and the TAA presentation inducer construct induces a polyclonal T cell response to the first TAA and to the one or more other TAAs. Also provided are methods of using the TAA presentation inducer constructs, for example, in the treatment of cancer.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB6s6j1zbSJCm-nrn0ze4LCmwVz3nTPUXgzZ8Hr_pY3m7YovJk3ESj2es0ehdcb-hVebd_xZu4MhTezVgKleRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJvHeQkYGhpYGhsamBgbmjMXGqAI5NP1s</recordid><startdate>20191205</startdate><enddate>20191205</enddate><creator>MILLS DAVID M</creator><creator>ESCOBAR CABRERA ERIC</creator><scope>EVB</scope></search><sort><creationdate>20191205</creationdate><title>종양 항원 제시 유도체 작제물 및 그의 용도</title><author>MILLS DAVID M ; ESCOBAR CABRERA ERIC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20190135007A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2019</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MILLS DAVID M</creatorcontrib><creatorcontrib>ESCOBAR CABRERA ERIC</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MILLS DAVID M</au><au>ESCOBAR CABRERA ERIC</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>종양 항원 제시 유도체 작제물 및 그의 용도</title><date>2019-12-05</date><risdate>2019</risdate><abstract>항원-제시 세포 (APC) 상에 발현된 ISR에 결합한 적어도 하나 선천성 자극 수용체 (ISR)-결합 작제물, 및 하나 이상의 다른 TAA를 포함하는 종양 세포-유래 물질 (TCDM)과 물리적으로 연결된 제1 TAA에 직접 결합된 적어도 하나 TAA-결합 작제물을 포함하는 종양-관련 항원 (TAA) 제시 유발체 작제물이 본원에서 제공된다. 상기 ISR-결합 작제물 및 상기 TAA-결합 작제물은 서로 연결되고, 상기 TAA 제시 유발체 작제물은 제1 TAA 및 하나 이상의 다른 TAA에 대해 다중 클론 T 세포 반응을 유발한다. 또한, 예를 들어 암 치료에 있어서, 상기 TAA 제시 유발체 작제물을 사용하는 방법도 제공된다. Provided herein are tumor-associated antigen (TAA) presentation inducer constructs comprising at least one innate stimulatory receptor (ISR)-binding construct that binds to an ISR expressed on an antigen-presenting cell (APC), and at least one TAA-binding construct that binds directly to a first TAA that is physically associated with tumor cell-derived material (TCDM) comprising one or more other TAAs. The ISR-binding construct and TAA-binding construct are linked to each other, and the TAA presentation inducer construct induces a polyclonal T cell response to the first TAA and to the one or more other TAAs. Also provided are methods of using the TAA presentation inducer constructs, for example, in the treatment of cancer.</abstract><oa>free_for_read</oa></addata></record>
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
title	종양 항원 제시 유도체 작제물 및 그의 용도
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