radish Nrf2 Nrf2 activating composition containing radish extract as an active ingredient and a method for producing the radish extract
The present invention relates to a composition for inducing the activation and expression of Nrf2, comprising a radish extract as an effective component, and more particularly, the present invention has confirmed that the composition expresses, by activating a transcription factor, Nrf2, NADPH produ...
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| creator | KIM, GI OK JUNG YONG HWAN YANG DA WUN OH DONG KWAN LEE NAM HO HONG SEUNG HYUN |
| description | The present invention relates to a composition for inducing the activation and expression of Nrf2, comprising a radish extract as an effective component, and more particularly, the present invention has confirmed that the composition expresses, by activating a transcription factor, Nrf2, NADPH production regulatory gene, GSH production regulatory gene, quinone detoxification gene, iron regulatory gene, redox homeostasis regulatory gene, heme metabolism gene, and the like. By using liver cells, HepG2 cells, RAW264.7 cells used as an inflammation model, and 3T3L1 cells whose mechanism of adipocyte differentiation is extensively studied, the present invention has confirmed that Nrf2 activation due to the composition results in 1) the effect of suppressing the differentiation from liver cells to fat liver cells, 2) anti-inflammatory effect in inflammatory cells, and 3) the effect of suppressing the differentiation from preadipocytes to adipocytes.
본 발명은 무(radish) 추출물을 유효성분으로 포함하는 Nrf2 활성화 및 발현유도 조성물에 관한 것으로, 상기 조성물이 전사인자인 Nrf2를 활성화 시켜 NADPH 생산 조절 유전자, GSH 생산조절 유전자, Quinone 디톡스 유전자, iron 조절유전자, redox homeostasis 조절 유전자, Heme metabolism 유전자 등을 발현시키는 것을 확인하였다. 본 발명에서는 간세포인 HepG2 세포, 염증모델로 이용되는 RAW264.7 세포, 지방세포로의 분화 기작이 잘 알려진 3T3L1 세포를 이용하여, 상기 조성물에 의한 Nrf2 활성화 작용으로 1) 간세포에서 지방간 세포로의 분화억제 효과, 2) 염증세포에서의 항염증 효과 3) 전구지방세포의 지방세포로의 분화 억제 효과를 확인하였다. |
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본 발명은 무(radish) 추출물을 유효성분으로 포함하는 Nrf2 활성화 및 발현유도 조성물에 관한 것으로, 상기 조성물이 전사인자인 Nrf2를 활성화 시켜 NADPH 생산 조절 유전자, GSH 생산조절 유전자, Quinone 디톡스 유전자, iron 조절유전자, redox homeostasis 조절 유전자, Heme metabolism 유전자 등을 발현시키는 것을 확인하였다. 본 발명에서는 간세포인 HepG2 세포, 염증모델로 이용되는 RAW264.7 세포, 지방세포로의 분화 기작이 잘 알려진 3T3L1 세포를 이용하여, 상기 조성물에 의한 Nrf2 활성화 작용으로 1) 간세포에서 지방간 세포로의 분화억제 효과, 2) 염증세포에서의 항염증 효과 3) 전구지방세포의 지방세포로의 분화 억제 효과를 확인하였다.</description><language>eng ; kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190826&DB=EPODOC&CC=KR&NR=20190099183A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190826&DB=EPODOC&CC=KR&NR=20190099183A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM, GI OK</creatorcontrib><creatorcontrib>JUNG YONG HWAN</creatorcontrib><creatorcontrib>YANG DA WUN</creatorcontrib><creatorcontrib>OH DONG KWAN</creatorcontrib><creatorcontrib>LEE NAM HO</creatorcontrib><creatorcontrib>HONG SEUNG HYUN</creatorcontrib><title>radish Nrf2 Nrf2 activating composition containing radish extract as an active ingredient and a method for producing the radish extract</title><description>The present invention relates to a composition for inducing the activation and expression of Nrf2, comprising a radish extract as an effective component, and more particularly, the present invention has confirmed that the composition expresses, by activating a transcription factor, Nrf2, NADPH production regulatory gene, GSH production regulatory gene, quinone detoxification gene, iron regulatory gene, redox homeostasis regulatory gene, heme metabolism gene, and the like. By using liver cells, HepG2 cells, RAW264.7 cells used as an inflammation model, and 3T3L1 cells whose mechanism of adipocyte differentiation is extensively studied, the present invention has confirmed that Nrf2 activation due to the composition results in 1) the effect of suppressing the differentiation from liver cells to fat liver cells, 2) anti-inflammatory effect in inflammatory cells, and 3) the effect of suppressing the differentiation from preadipocytes to adipocytes.
본 발명은 무(radish) 추출물을 유효성분으로 포함하는 Nrf2 활성화 및 발현유도 조성물에 관한 것으로, 상기 조성물이 전사인자인 Nrf2를 활성화 시켜 NADPH 생산 조절 유전자, GSH 생산조절 유전자, Quinone 디톡스 유전자, iron 조절유전자, redox homeostasis 조절 유전자, Heme metabolism 유전자 등을 발현시키는 것을 확인하였다. 본 발명에서는 간세포인 HepG2 세포, 염증모델로 이용되는 RAW264.7 세포, 지방세포로의 분화 기작이 잘 알려진 3T3L1 세포를 이용하여, 상기 조성물에 의한 Nrf2 활성화 작용으로 1) 간세포에서 지방간 세포로의 분화억제 효과, 2) 염증세포에서의 항염증 효과 3) 전구지방세포의 지방세포로의 분화 억제 효과를 확인하였다.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTLsKwkAQTGMh6j8sWAt5NKYUUQTBQuzDcrcxC2bvuFvFP_C3vZBUVjYzw7zm2Seg5djBJbTlCGiUX6gsdzCu9y6yspOkRZFlsKcJvTWkMmAElHFGkPJAlkmSLxYQetLOWWhdAB-cfZrhQTv6eVlmsxYfkVYTL7L18XDbnzbkXUPRoyEhbc7XMi_qPK_rYlvtqv9aX3RuTI0</recordid><startdate>20190826</startdate><enddate>20190826</enddate><creator>KIM, GI OK</creator><creator>JUNG YONG HWAN</creator><creator>YANG DA WUN</creator><creator>OH DONG KWAN</creator><creator>LEE NAM HO</creator><creator>HONG SEUNG HYUN</creator><scope>EVB</scope></search><sort><creationdate>20190826</creationdate><title>radish Nrf2 Nrf2 activating composition containing radish extract as an active ingredient and a method for producing the radish extract</title><author>KIM, GI OK ; JUNG YONG HWAN ; YANG DA WUN ; OH DONG KWAN ; LEE NAM HO ; HONG SEUNG HYUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20190099183A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM, GI OK</creatorcontrib><creatorcontrib>JUNG YONG HWAN</creatorcontrib><creatorcontrib>YANG DA WUN</creatorcontrib><creatorcontrib>OH DONG KWAN</creatorcontrib><creatorcontrib>LEE NAM HO</creatorcontrib><creatorcontrib>HONG SEUNG HYUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM, GI OK</au><au>JUNG YONG HWAN</au><au>YANG DA WUN</au><au>OH DONG KWAN</au><au>LEE NAM HO</au><au>HONG SEUNG HYUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>radish Nrf2 Nrf2 activating composition containing radish extract as an active ingredient and a method for producing the radish extract</title><date>2019-08-26</date><risdate>2019</risdate><abstract>The present invention relates to a composition for inducing the activation and expression of Nrf2, comprising a radish extract as an effective component, and more particularly, the present invention has confirmed that the composition expresses, by activating a transcription factor, Nrf2, NADPH production regulatory gene, GSH production regulatory gene, quinone detoxification gene, iron regulatory gene, redox homeostasis regulatory gene, heme metabolism gene, and the like. By using liver cells, HepG2 cells, RAW264.7 cells used as an inflammation model, and 3T3L1 cells whose mechanism of adipocyte differentiation is extensively studied, the present invention has confirmed that Nrf2 activation due to the composition results in 1) the effect of suppressing the differentiation from liver cells to fat liver cells, 2) anti-inflammatory effect in inflammatory cells, and 3) the effect of suppressing the differentiation from preadipocytes to adipocytes.
본 발명은 무(radish) 추출물을 유효성분으로 포함하는 Nrf2 활성화 및 발현유도 조성물에 관한 것으로, 상기 조성물이 전사인자인 Nrf2를 활성화 시켜 NADPH 생산 조절 유전자, GSH 생산조절 유전자, Quinone 디톡스 유전자, iron 조절유전자, redox homeostasis 조절 유전자, Heme metabolism 유전자 등을 발현시키는 것을 확인하였다. 본 발명에서는 간세포인 HepG2 세포, 염증모델로 이용되는 RAW264.7 세포, 지방세포로의 분화 기작이 잘 알려진 3T3L1 세포를 이용하여, 상기 조성물에 의한 Nrf2 활성화 작용으로 1) 간세포에서 지방간 세포로의 분화억제 효과, 2) 염증세포에서의 항염증 효과 3) 전구지방세포의 지방세포로의 분화 억제 효과를 확인하였다.</abstract><oa>free_for_read</oa></addata></record> |
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| title | radish Nrf2 Nrf2 activating composition containing radish extract as an active ingredient and a method for producing the radish extract |
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