ROR 감마 조절인자로서 신규의 카보사이클릭 화합물
본 발명은 레티노이드-관련 고아 수용체 감마 t (RORγt)의 조절인자로서 활성인 신규의 카보사이클릭 화학식 (I)의 화합물 및 이의 약제학적으로 허용되는 염에 관한 것으로, 여기서 R, R, R, R, R, R, R, R, n, m 및 p는 본 발명에 정의된 바와 같다. 이러한 화합물은 RORγt의 활성을 예방, 저해 또는 억제하여, RORγt 매개성 질병, 질환, 증후군 또는 병태, 예컨대, 통증, 염증, COPD, 천식, 류마티스 관절염, 대장염, 다발성 경화증, 건선, 신경변성 질환 및 암의 치료에 유용하다. The pre...
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| creator | BAJPAI MALINI SHELKE DNYANESHWAR EKNATH KHAIRATKAR JOSHI NEELIMA HARDE RAJENDRA LAXMAN PARDESHI SHAILESH RAMESH DAS SANJIB GHARAT LAXMIKANT ATMARAM THOMAS ABRAHAM SHAH DAISY MANISH |
| description | 본 발명은 레티노이드-관련 고아 수용체 감마 t (RORγt)의 조절인자로서 활성인 신규의 카보사이클릭 화학식 (I)의 화합물 및 이의 약제학적으로 허용되는 염에 관한 것으로, 여기서 R, R, R, R, R, R, R, R, n, m 및 p는 본 발명에 정의된 바와 같다. 이러한 화합물은 RORγt의 활성을 예방, 저해 또는 억제하여, RORγt 매개성 질병, 질환, 증후군 또는 병태, 예컨대, 통증, 염증, COPD, 천식, 류마티스 관절염, 대장염, 다발성 경화증, 건선, 신경변성 질환 및 암의 치료에 유용하다.
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_KR20180044384A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>KR20180044384A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_KR20180044384A3</originalsourceid><addsrcrecordid>eNrjZHAJ8g9SeLVhwuvlHQpvFm54s6Djzdwdb-ZNeL1wzpuWOQpvuhe82j7nzdwZCm92bnm9ecubpjVv5m5527jl9bK1Cm9nTnk7deXrNXt4GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakm8d5CRgaGFgYGJibGFiaMxcaoA6adHMQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ROR 감마 조절인자로서 신규의 카보사이클릭 화합물</title><source>esp@cenet</source><creator>BAJPAI MALINI ; SHELKE DNYANESHWAR EKNATH ; KHAIRATKAR JOSHI NEELIMA ; HARDE RAJENDRA LAXMAN ; PARDESHI SHAILESH RAMESH ; DAS SANJIB ; GHARAT LAXMIKANT ATMARAM ; THOMAS ABRAHAM ; SHAH DAISY MANISH</creator><creatorcontrib>BAJPAI MALINI ; SHELKE DNYANESHWAR EKNATH ; KHAIRATKAR JOSHI NEELIMA ; HARDE RAJENDRA LAXMAN ; PARDESHI SHAILESH RAMESH ; DAS SANJIB ; GHARAT LAXMIKANT ATMARAM ; THOMAS ABRAHAM ; SHAH DAISY MANISH</creatorcontrib><description>본 발명은 레티노이드-관련 고아 수용체 감마 t (RORγt)의 조절인자로서 활성인 신규의 카보사이클릭 화학식 (I)의 화합물 및 이의 약제학적으로 허용되는 염에 관한 것으로, 여기서 R, R, R, R, R, R, R, R, n, m 및 p는 본 발명에 정의된 바와 같다. 이러한 화합물은 RORγt의 활성을 예방, 저해 또는 억제하여, RORγt 매개성 질병, 질환, 증후군 또는 병태, 예컨대, 통증, 염증, COPD, 천식, 류마티스 관절염, 대장염, 다발성 경화증, 건선, 신경변성 질환 및 암의 치료에 유용하다.
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.</description><language>kor</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180502&DB=EPODOC&CC=KR&NR=20180044384A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180502&DB=EPODOC&CC=KR&NR=20180044384A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BAJPAI MALINI</creatorcontrib><creatorcontrib>SHELKE DNYANESHWAR EKNATH</creatorcontrib><creatorcontrib>KHAIRATKAR JOSHI NEELIMA</creatorcontrib><creatorcontrib>HARDE RAJENDRA LAXMAN</creatorcontrib><creatorcontrib>PARDESHI SHAILESH RAMESH</creatorcontrib><creatorcontrib>DAS SANJIB</creatorcontrib><creatorcontrib>GHARAT LAXMIKANT ATMARAM</creatorcontrib><creatorcontrib>THOMAS ABRAHAM</creatorcontrib><creatorcontrib>SHAH DAISY MANISH</creatorcontrib><title>ROR 감마 조절인자로서 신규의 카보사이클릭 화합물</title><description>본 발명은 레티노이드-관련 고아 수용체 감마 t (RORγt)의 조절인자로서 활성인 신규의 카보사이클릭 화학식 (I)의 화합물 및 이의 약제학적으로 허용되는 염에 관한 것으로, 여기서 R, R, R, R, R, R, R, R, n, m 및 p는 본 발명에 정의된 바와 같다. 이러한 화합물은 RORγt의 활성을 예방, 저해 또는 억제하여, RORγt 매개성 질병, 질환, 증후군 또는 병태, 예컨대, 통증, 염증, COPD, 천식, 류마티스 관절염, 대장염, 다발성 경화증, 건선, 신경변성 질환 및 암의 치료에 유용하다.
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAJ8g9SeLVhwuvlHQpvFm54s6Djzdwdb-ZNeL1wzpuWOQpvuhe82j7nzdwZCm92bnm9ecubpjVv5m5527jl9bK1Cm9nTnk7deXrNXt4GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakm8d5CRgaGFgYGJibGFiaMxcaoA6adHMQ</recordid><startdate>20180502</startdate><enddate>20180502</enddate><creator>BAJPAI MALINI</creator><creator>SHELKE DNYANESHWAR EKNATH</creator><creator>KHAIRATKAR JOSHI NEELIMA</creator><creator>HARDE RAJENDRA LAXMAN</creator><creator>PARDESHI SHAILESH RAMESH</creator><creator>DAS SANJIB</creator><creator>GHARAT LAXMIKANT ATMARAM</creator><creator>THOMAS ABRAHAM</creator><creator>SHAH DAISY MANISH</creator><scope>EVB</scope></search><sort><creationdate>20180502</creationdate><title>ROR 감마 조절인자로서 신규의 카보사이클릭 화합물</title><author>BAJPAI MALINI ; SHELKE DNYANESHWAR EKNATH ; KHAIRATKAR JOSHI NEELIMA ; HARDE RAJENDRA LAXMAN ; PARDESHI SHAILESH RAMESH ; DAS SANJIB ; GHARAT LAXMIKANT ATMARAM ; THOMAS ABRAHAM ; SHAH DAISY MANISH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20180044384A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2018</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BAJPAI MALINI</creatorcontrib><creatorcontrib>SHELKE DNYANESHWAR EKNATH</creatorcontrib><creatorcontrib>KHAIRATKAR JOSHI NEELIMA</creatorcontrib><creatorcontrib>HARDE RAJENDRA LAXMAN</creatorcontrib><creatorcontrib>PARDESHI SHAILESH RAMESH</creatorcontrib><creatorcontrib>DAS SANJIB</creatorcontrib><creatorcontrib>GHARAT LAXMIKANT ATMARAM</creatorcontrib><creatorcontrib>THOMAS ABRAHAM</creatorcontrib><creatorcontrib>SHAH DAISY MANISH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BAJPAI MALINI</au><au>SHELKE DNYANESHWAR EKNATH</au><au>KHAIRATKAR JOSHI NEELIMA</au><au>HARDE RAJENDRA LAXMAN</au><au>PARDESHI SHAILESH RAMESH</au><au>DAS SANJIB</au><au>GHARAT LAXMIKANT ATMARAM</au><au>THOMAS ABRAHAM</au><au>SHAH DAISY MANISH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ROR 감마 조절인자로서 신규의 카보사이클릭 화합물</title><date>2018-05-02</date><risdate>2018</risdate><abstract>본 발명은 레티노이드-관련 고아 수용체 감마 t (RORγt)의 조절인자로서 활성인 신규의 카보사이클릭 화학식 (I)의 화합물 및 이의 약제학적으로 허용되는 염에 관한 것으로, 여기서 R, R, R, R, R, R, R, R, n, m 및 p는 본 발명에 정의된 바와 같다. 이러한 화합물은 RORγt의 활성을 예방, 저해 또는 억제하여, RORγt 매개성 질병, 질환, 증후군 또는 병태, 예컨대, 통증, 염증, COPD, 천식, 류마티스 관절염, 대장염, 다발성 경화증, 건선, 신경변성 질환 및 암의 치료에 유용하다.
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| title | ROR 감마 조절인자로서 신규의 카보사이클릭 화합물 |
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