Peptide Nucleic Acid Complex with Increased Cell Permeability and pharmaceutical composition comprising the same

The present invention relates to a novel structure of nucleic acid complex in which bioactive nucleic acid can be introduced into cells, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using...

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Bibliographische Detailangaben
Hauptverfasser:	PARK, HEE KYUNG, JEO, GOON HO, YU, JI YEON, HUR, DEOK HWE, KIM, HYE JOO, BATOCHIR CHINBAYAR
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a novel structure of nucleic acid complex in which bioactive nucleic acid can be introduced into cells, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same and, more specifically, to a nucleic acid complex in which a bioactive nucleic acid is complementarily combined with a carrier peptide nucleic acid modified to have a positive charge overall, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same. 본 발명은 생활성 핵산을 세포내에 도입할 수 있는 새로운 구조의 핵산 복합체, 이를 포함하는 질병의 치료 및 진단용 조성물 및 이를 이용한 표적 유전자의 발현 조절 방법에 관한 것으로, 더욱 자세하게는, 생활성 핵산과 전체적으로 양전하를 가지도록 변형된 캐리어 펩티드 핵산(Carrier Peptide Nucleic Acid)이 상보적으로 결합된 핵산 복합체 이를 포함하는 질병의 치료 및 진단용 조성물 및 이를 이용한 표적 유전자의 발현 조절 방법에 관한 것이다.