ALK EML4-ALK Method of providing the information for selecting the drugs for treating EML4-ALK positive non-small-cell lung cancer resistant to ALK inhibitors
The present invention provides a biomarker for providing information on drug selection for the treatment of EML4-ALK-positive non-small-cell lung cancer which has acquired resistance to ALK inhibitors. The present invention can provide a method, a composition, and a kit for detecting the expression...
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| creator | CHOI, HUN MI YOON, MI RAN KIM, HYE RYUN LIM, SUN MIN CHO, BYOUNG CHUL |
| description | The present invention provides a biomarker for providing information on drug selection for the treatment of EML4-ALK-positive non-small-cell lung cancer which has acquired resistance to ALK inhibitors. The present invention can provide a method, a composition, and a kit for detecting the expression levels of miR-34a and/or miR-449 to provide information on drug selection for the treatment of EML4-ALK-positive non-small-cell lung cancer which has acquired resistance to ALK inhibitors.
본 발명은 ALK 저해제에 내성을 획득한 EML4-ALK 양성 비소세포폐암의 치료에 있어서 약물 선택의 정보를 제공하기 위한 바이오마커를 제공하는 것으로, ALK 저해제에 내성을 획득한 EML4-ALK 양성 비소세포폐암의 치료에 있어서 약물 선택의 정보를 제공하기 위해 miR-34a 및/또는 miR-449의 발현 수준을 탐지하기 위한 방법, 조성물 및 키트를 제공할 수 있다. |
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본 발명은 ALK 저해제에 내성을 획득한 EML4-ALK 양성 비소세포폐암의 치료에 있어서 약물 선택의 정보를 제공하기 위한 바이오마커를 제공하는 것으로, ALK 저해제에 내성을 획득한 EML4-ALK 양성 비소세포폐암의 치료에 있어서 약물 선택의 정보를 제공하기 위해 miR-34a 및/또는 miR-449의 발현 수준을 탐지하기 위한 방법, 조성물 및 키트를 제공할 수 있다.</description><language>eng ; kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180212&DB=EPODOC&CC=KR&NR=20180014967A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180212&DB=EPODOC&CC=KR&NR=20180014967A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHOI, HUN MI</creatorcontrib><creatorcontrib>YOON, MI RAN</creatorcontrib><creatorcontrib>KIM, HYE RYUN</creatorcontrib><creatorcontrib>LIM, SUN MIN</creatorcontrib><creatorcontrib>CHO, BYOUNG CHUL</creatorcontrib><title>ALK EML4-ALK Method of providing the information for selecting the drugs for treating EML4-ALK positive non-small-cell lung cancer resistant to ALK inhibitors</title><description>The present invention provides a biomarker for providing information on drug selection for the treatment of EML4-ALK-positive non-small-cell lung cancer which has acquired resistance to ALK inhibitors. The present invention can provide a method, a composition, and a kit for detecting the expression levels of miR-34a and/or miR-449 to provide information on drug selection for the treatment of EML4-ALK-positive non-small-cell lung cancer which has acquired resistance to ALK inhibitors.
본 발명은 ALK 저해제에 내성을 획득한 EML4-ALK 양성 비소세포폐암의 치료에 있어서 약물 선택의 정보를 제공하기 위한 바이오마커를 제공하는 것으로, ALK 저해제에 내성을 획득한 EML4-ALK 양성 비소세포폐암의 치료에 있어서 약물 선택의 정보를 제공하기 위해 miR-34a 및/또는 miR-449의 발현 수준을 탐지하기 위한 방법, 조성물 및 키트를 제공할 수 있다.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLkKwkAQhtNYiPoOA9aBeOBRiihCYiP2sm4mZmCdCTtjHsdn9UCtrf6P_-om91WRw2ZfTNMX7NFqKUEqaKK0VBJfwGoE4kri1RkJw5NAMaC3b1rG20XfvkV0b_v32IiSUYvAwqleXQipxxAg3J4t79hjhIhKao4NTOA1Iq7pTCZR-0mnckFx8NFeMtxujutdio2cUBvnkdFO-WGcjRZZNpouZ_PV5L_WA7W5Utg</recordid><startdate>20180212</startdate><enddate>20180212</enddate><creator>CHOI, HUN MI</creator><creator>YOON, MI RAN</creator><creator>KIM, HYE RYUN</creator><creator>LIM, SUN MIN</creator><creator>CHO, BYOUNG CHUL</creator><scope>EVB</scope></search><sort><creationdate>20180212</creationdate><title>ALK EML4-ALK Method of providing the information for selecting the drugs for treating EML4-ALK positive non-small-cell lung cancer resistant to ALK inhibitors</title><author>CHOI, HUN MI ; YOON, MI RAN ; KIM, HYE RYUN ; LIM, SUN MIN ; CHO, BYOUNG CHUL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20180014967A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHOI, HUN MI</creatorcontrib><creatorcontrib>YOON, MI RAN</creatorcontrib><creatorcontrib>KIM, HYE RYUN</creatorcontrib><creatorcontrib>LIM, SUN MIN</creatorcontrib><creatorcontrib>CHO, BYOUNG CHUL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHOI, HUN MI</au><au>YOON, MI RAN</au><au>KIM, HYE RYUN</au><au>LIM, SUN MIN</au><au>CHO, BYOUNG CHUL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ALK EML4-ALK Method of providing the information for selecting the drugs for treating EML4-ALK positive non-small-cell lung cancer resistant to ALK inhibitors</title><date>2018-02-12</date><risdate>2018</risdate><abstract>The present invention provides a biomarker for providing information on drug selection for the treatment of EML4-ALK-positive non-small-cell lung cancer which has acquired resistance to ALK inhibitors. The present invention can provide a method, a composition, and a kit for detecting the expression levels of miR-34a and/or miR-449 to provide information on drug selection for the treatment of EML4-ALK-positive non-small-cell lung cancer which has acquired resistance to ALK inhibitors.
본 발명은 ALK 저해제에 내성을 획득한 EML4-ALK 양성 비소세포폐암의 치료에 있어서 약물 선택의 정보를 제공하기 위한 바이오마커를 제공하는 것으로, ALK 저해제에 내성을 획득한 EML4-ALK 양성 비소세포폐암의 치료에 있어서 약물 선택의 정보를 제공하기 위해 miR-34a 및/또는 miR-449의 발현 수준을 탐지하기 위한 방법, 조성물 및 키트를 제공할 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | ALK EML4-ALK Method of providing the information for selecting the drugs for treating EML4-ALK positive non-small-cell lung cancer resistant to ALK inhibitors |
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