PDE10 억제제 및 관련 조성물 및 방법
본원에 PDE10을 억제하는 단리된 또는 순수한 화합물이 기재되며, 상기 화합물은, 정신병적, 불안, 기분 장애 및/또는 신경 장애, 예컨대, 파킨슨 병, 헌팅턴 병, 알츠하이머 병, 뇌염, 공포증, 간질, 실어증, 벨 마비, 뇌성 마비, 수면 장애, 통증, 투렛 증후군, 조현병, 망상 장애, 약물-유발 정신증 및 공황 및 강박 장애를 비롯한 다양한 병증의 치료에 유용성을 갖는다. 상기 화합물의 약학적으로 허용가능한 염, 입체이성질체, 용매화물 및 전구약물 또한 본원에 제공된다. 또한, 상기 단리된 또는 순수한 화합물과 함께 약학적...
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| creator | VARAPRASAD BOTLA DURGA BOMMAGANI RAGHURAM REDDY KARNATI LAXMA HARBOL KEVIN L NARAYANAN SATYAMURTHI GAGE JENNIFER LYNN |
| description | 본원에 PDE10을 억제하는 단리된 또는 순수한 화합물이 기재되며, 상기 화합물은, 정신병적, 불안, 기분 장애 및/또는 신경 장애, 예컨대, 파킨슨 병, 헌팅턴 병, 알츠하이머 병, 뇌염, 공포증, 간질, 실어증, 벨 마비, 뇌성 마비, 수면 장애, 통증, 투렛 증후군, 조현병, 망상 장애, 약물-유발 정신증 및 공황 및 강박 장애를 비롯한 다양한 병증의 치료에 유용성을 갖는다. 상기 화합물의 약학적으로 허용가능한 염, 입체이성질체, 용매화물 및 전구약물 또한 본원에 제공된다. 또한, 상기 단리된 또는 순수한 화합물과 함께 약학적으로 허용가능한 담체를 포함하는 조성물 뿐만 아니라, PDE10의 억제를 필요로 하는 온혈 동물에서 PDE10을 억제하기 위한 이의 사용 방법이 기재된다.
Isolated or pure compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including but not limited to psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing an isolated or pure compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same. |
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Isolated or pure compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including but not limited to psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing an isolated or pure compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.</description><language>kor</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SUGARS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171218&DB=EPODOC&CC=KR&NR=20170139074A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171218&DB=EPODOC&CC=KR&NR=20170139074A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VARAPRASAD BOTLA DURGA</creatorcontrib><creatorcontrib>BOMMAGANI RAGHURAM</creatorcontrib><creatorcontrib>REDDY KARNATI LAXMA</creatorcontrib><creatorcontrib>HARBOL KEVIN L</creatorcontrib><creatorcontrib>NARAYANAN SATYAMURTHI</creatorcontrib><creatorcontrib>GAGE JENNIFER LYNN</creatorcontrib><title>PDE10 억제제 및 관련 조성물 및 방법</title><description>본원에 PDE10을 억제하는 단리된 또는 순수한 화합물이 기재되며, 상기 화합물은, 정신병적, 불안, 기분 장애 및/또는 신경 장애, 예컨대, 파킨슨 병, 헌팅턴 병, 알츠하이머 병, 뇌염, 공포증, 간질, 실어증, 벨 마비, 뇌성 마비, 수면 장애, 통증, 투렛 증후군, 조현병, 망상 장애, 약물-유발 정신증 및 공황 및 강박 장애를 비롯한 다양한 병증의 치료에 유용성을 갖는다. 상기 화합물의 약학적으로 허용가능한 염, 입체이성질체, 용매화물 및 전구약물 또한 본원에 제공된다. 또한, 상기 단리된 또는 순수한 화합물과 함께 약학적으로 허용가능한 담체를 포함하는 조성물 뿐만 아니라, PDE10의 억제를 필요로 하는 온혈 동물에서 PDE10을 억제하기 위한 이의 사용 방법이 기재된다.
Isolated or pure compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including but not limited to psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing an isolated or pure compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAPcHE1NFB4M23rmwVzgEjh9YZ-hVdbGl4vWKHwZuGGNy0bX6_ZAxZ8vWHl601TeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJvHeQkYGhuYGhsaWBuYmjMXGqAGd5NkM</recordid><startdate>20171218</startdate><enddate>20171218</enddate><creator>VARAPRASAD BOTLA DURGA</creator><creator>BOMMAGANI RAGHURAM</creator><creator>REDDY KARNATI LAXMA</creator><creator>HARBOL KEVIN L</creator><creator>NARAYANAN SATYAMURTHI</creator><creator>GAGE JENNIFER LYNN</creator><scope>EVB</scope></search><sort><creationdate>20171218</creationdate><title>PDE10 억제제 및 관련 조성물 및 방법</title><author>VARAPRASAD BOTLA DURGA ; BOMMAGANI RAGHURAM ; REDDY KARNATI LAXMA ; HARBOL KEVIN L ; NARAYANAN SATYAMURTHI ; GAGE JENNIFER LYNN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20170139074A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>VARAPRASAD BOTLA DURGA</creatorcontrib><creatorcontrib>BOMMAGANI RAGHURAM</creatorcontrib><creatorcontrib>REDDY KARNATI LAXMA</creatorcontrib><creatorcontrib>HARBOL KEVIN L</creatorcontrib><creatorcontrib>NARAYANAN SATYAMURTHI</creatorcontrib><creatorcontrib>GAGE JENNIFER LYNN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VARAPRASAD BOTLA DURGA</au><au>BOMMAGANI RAGHURAM</au><au>REDDY KARNATI LAXMA</au><au>HARBOL KEVIN L</au><au>NARAYANAN SATYAMURTHI</au><au>GAGE JENNIFER LYNN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PDE10 억제제 및 관련 조성물 및 방법</title><date>2017-12-18</date><risdate>2017</risdate><abstract>본원에 PDE10을 억제하는 단리된 또는 순수한 화합물이 기재되며, 상기 화합물은, 정신병적, 불안, 기분 장애 및/또는 신경 장애, 예컨대, 파킨슨 병, 헌팅턴 병, 알츠하이머 병, 뇌염, 공포증, 간질, 실어증, 벨 마비, 뇌성 마비, 수면 장애, 통증, 투렛 증후군, 조현병, 망상 장애, 약물-유발 정신증 및 공황 및 강박 장애를 비롯한 다양한 병증의 치료에 유용성을 갖는다. 상기 화합물의 약학적으로 허용가능한 염, 입체이성질체, 용매화물 및 전구약물 또한 본원에 제공된다. 또한, 상기 단리된 또는 순수한 화합물과 함께 약학적으로 허용가능한 담체를 포함하는 조성물 뿐만 아니라, PDE10의 억제를 필요로 하는 온혈 동물에서 PDE10을 억제하기 위한 이의 사용 방법이 기재된다.
Isolated or pure compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including but not limited to psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing an isolated or pure compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PDE10 억제제 및 관련 조성물 및 방법 |
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