Nanoparticle for improving intestinal permeability and thereof production method
The present invention relates to intestinal permeable nanoparticles manufactured by mixing chitosan and dextran sulfate at a weight ratio of 1 : 0.2-1, and to a production method thereof. The chitosan/dextran sulfate nanoparticles manufactured by the present invention shows excellent enterocyte adso...
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| creator | LEE, HYEON GYU KIM, EUN SUH LEE, JI SOO SUH, JI WOON JE, HYUN JEONG |
| description | The present invention relates to intestinal permeable nanoparticles manufactured by mixing chitosan and dextran sulfate at a weight ratio of 1 : 0.2-1, and to a production method thereof. The chitosan/dextran sulfate nanoparticles manufactured by the present invention shows excellent enterocyte adsorption abilities and collects an object to be collected (target material) which has low solubility, is unstable and has low internal resorption rates such as coenzyme Q10, thereby significantly increasing absorption of the object to be collected to enterocyte and increasing internal resorption rates of the object to be collected.
본 발명은 키토산 및 덱스트란 설페이트를 1 : 0.2 ~ 1 중량비로 혼합하여 제조된 것을 특징으로 하는 장 투과성 나노입자 및 그 제조방법에 관한 것으로, 다. 본 발명에 의해 제조된 키토산/덱스트란 설페이트 나노입자는 우수한 장 세포 흡착능을 발휘하는데, 코엔자임Q10과 같이 용해도가 낮고, 불안정하며 체내 흡수율이 낮은 포집대상물(목적물질)을 포집함으로써, 포집대상물질의 장 세포로의 흡수를 현저히 향상시켜, 이들 포집대상물질의 체내 흡수율을 증진시킬 수 있다. |
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본 발명은 키토산 및 덱스트란 설페이트를 1 : 0.2 ~ 1 중량비로 혼합하여 제조된 것을 특징으로 하는 장 투과성 나노입자 및 그 제조방법에 관한 것으로, 다. 본 발명에 의해 제조된 키토산/덱스트란 설페이트 나노입자는 우수한 장 세포 흡착능을 발휘하는데, 코엔자임Q10과 같이 용해도가 낮고, 불안정하며 체내 흡수율이 낮은 포집대상물(목적물질)을 포집함으로써, 포집대상물질의 장 세포로의 흡수를 현저히 향상시켜, 이들 포집대상물질의 체내 흡수율을 증진시킬 수 있다.</description><language>eng ; kor</language><subject>FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HUMAN NECESSITIES ; HYGIENE ; INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLICBEVERAGES ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY ASINGLE OTHER SUBCLASS ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171113&DB=EPODOC&CC=KR&NR=20170124689A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171113&DB=EPODOC&CC=KR&NR=20170124689A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEE, HYEON GYU</creatorcontrib><creatorcontrib>KIM, EUN SUH</creatorcontrib><creatorcontrib>LEE, JI SOO</creatorcontrib><creatorcontrib>SUH, JI WOON</creatorcontrib><creatorcontrib>JE, HYUN JEONG</creatorcontrib><title>Nanoparticle for improving intestinal permeability and thereof production method</title><description>The present invention relates to intestinal permeable nanoparticles manufactured by mixing chitosan and dextran sulfate at a weight ratio of 1 : 0.2-1, and to a production method thereof. The chitosan/dextran sulfate nanoparticles manufactured by the present invention shows excellent enterocyte adsorption abilities and collects an object to be collected (target material) which has low solubility, is unstable and has low internal resorption rates such as coenzyme Q10, thereby significantly increasing absorption of the object to be collected to enterocyte and increasing internal resorption rates of the object to be collected.
본 발명은 키토산 및 덱스트란 설페이트를 1 : 0.2 ~ 1 중량비로 혼합하여 제조된 것을 특징으로 하는 장 투과성 나노입자 및 그 제조방법에 관한 것으로, 다. 본 발명에 의해 제조된 키토산/덱스트란 설페이트 나노입자는 우수한 장 세포 흡착능을 발휘하는데, 코엔자임Q10과 같이 용해도가 낮고, 불안정하며 체내 흡수율이 낮은 포집대상물(목적물질)을 포집함으로써, 포집대상물질의 장 세포로의 흡수를 현저히 향상시켜, 이들 포집대상물질의 체내 흡수율을 증진시킬 수 있다.</description><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLICBEVERAGES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY ASINGLE OTHER SUBCLASS</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyr0KwkAMAOAuDqK-Q8BZaKv4M4oogiAi7iXe5WzgmhzXKPj2OvgATt_yDYvLGUUTZmMXCYJm4C5lfbE8gMWoNxaMkCh3hHeObG9A8WAtZdIA3-ufzlgFOrJW_bgYBIw9TX6Oiulhf9sdZ5S0oT6hIyFrTte6rFZlVS-W6812_t_6AAWzOU8</recordid><startdate>20171113</startdate><enddate>20171113</enddate><creator>LEE, HYEON GYU</creator><creator>KIM, EUN SUH</creator><creator>LEE, JI SOO</creator><creator>SUH, JI WOON</creator><creator>JE, HYUN JEONG</creator><scope>EVB</scope></search><sort><creationdate>20171113</creationdate><title>Nanoparticle for improving intestinal permeability and thereof production method</title><author>LEE, HYEON GYU ; KIM, EUN SUH ; LEE, JI SOO ; SUH, JI WOON ; JE, HYUN JEONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20170124689A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2017</creationdate><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLICBEVERAGES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY ASINGLE OTHER SUBCLASS</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><toplevel>online_resources</toplevel><creatorcontrib>LEE, HYEON GYU</creatorcontrib><creatorcontrib>KIM, EUN SUH</creatorcontrib><creatorcontrib>LEE, JI SOO</creatorcontrib><creatorcontrib>SUH, JI WOON</creatorcontrib><creatorcontrib>JE, HYUN JEONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEE, HYEON GYU</au><au>KIM, EUN SUH</au><au>LEE, JI SOO</au><au>SUH, JI WOON</au><au>JE, HYUN JEONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Nanoparticle for improving intestinal permeability and thereof production method</title><date>2017-11-13</date><risdate>2017</risdate><abstract>The present invention relates to intestinal permeable nanoparticles manufactured by mixing chitosan and dextran sulfate at a weight ratio of 1 : 0.2-1, and to a production method thereof. The chitosan/dextran sulfate nanoparticles manufactured by the present invention shows excellent enterocyte adsorption abilities and collects an object to be collected (target material) which has low solubility, is unstable and has low internal resorption rates such as coenzyme Q10, thereby significantly increasing absorption of the object to be collected to enterocyte and increasing internal resorption rates of the object to be collected.
본 발명은 키토산 및 덱스트란 설페이트를 1 : 0.2 ~ 1 중량비로 혼합하여 제조된 것을 특징으로 하는 장 투과성 나노입자 및 그 제조방법에 관한 것으로, 다. 본 발명에 의해 제조된 키토산/덱스트란 설페이트 나노입자는 우수한 장 세포 흡착능을 발휘하는데, 코엔자임Q10과 같이 용해도가 낮고, 불안정하며 체내 흡수율이 낮은 포집대상물(목적물질)을 포집함으로써, 포집대상물질의 장 세포로의 흡수를 현저히 향상시켜, 이들 포집대상물질의 체내 흡수율을 증진시킬 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLICBEVERAGES MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY ASINGLE OTHER SUBCLASS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
| title | Nanoparticle for improving intestinal permeability and thereof production method |
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