TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF

TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF

링커를 통해 활성제 예컨대 표적화 모이어티, 예컨대 소마토스타틴 수용체 결합 모이어티에 부착된 치료제, 예방제, 또는 진단제의 콘주게이트를 함유하는 나노입자 및 극미립자, 및 약제학적 그것의 제형이 설계되었다. 그와 같은 나노입자 및 극미립자는 활성제 및/또는 개선된 생체분포의 개선된 시간공간적 전달을 제공할 수 있다. 상기 콘주게이트, 상기 입자, 및 그것의 제형을 제조하는 방법이 제공된다. 상기 제형을 그것을 필요로 하는 대상체에게 투여하는 방법이 예를 들면, 암 또는 감염성 질환을 치료 또는 예방하기 위해 제공된다. Nanop...

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Hauptverfasser: BILODEAU MARK T, LIM SOO PATRICK, KADIYALA SUDHAKAR, SWERYDA KRAWIEC BEATA, ALARGOVA ROSSITZA G, BAZINET PATRICK ROSAIRE, DUNBAR CRAIG A, SHINDE RAJESH R, WHITE BRIAN H, WOOSTER RICHARD
Format: Patent
Sprache:eng ; kor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator BILODEAU MARK T
LIM SOO PATRICK
KADIYALA SUDHAKAR
SWERYDA KRAWIEC BEATA
ALARGOVA ROSSITZA G
BAZINET PATRICK ROSAIRE
DUNBAR CRAIG A
SHINDE RAJESH R
WHITE BRIAN H
WOOSTER RICHARD
description 링커를 통해 활성제 예컨대 표적화 모이어티, 예컨대 소마토스타틴 수용체 결합 모이어티에 부착된 치료제, 예방제, 또는 진단제의 콘주게이트를 함유하는 나노입자 및 극미립자, 및 약제학적 그것의 제형이 설계되었다. 그와 같은 나노입자 및 극미립자는 활성제 및/또는 개선된 생체분포의 개선된 시간공간적 전달을 제공할 수 있다. 상기 콘주게이트, 상기 입자, 및 그것의 제형을 제조하는 방법이 제공된다. 상기 제형을 그것을 필요로 하는 대상체에게 투여하는 방법이 예를 들면, 암 또는 감염성 질환을 치료 또는 예방하기 위해 제공된다. Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
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Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.</abstract><oa>free_for_read</oa></addata></record>
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MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
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