O-GlcNAc UDP-GlcNAc C1- C1-phosphonate analogue of UDP-GlcNAc for the inhibition of O-GlcNAc transferase

The present invention relates to C1-phosphonate derivatives of new uridine-5-diphosphate (UDP)-GlcNAc, which is effective for an O-linked N-acetylglucosamine (O-GlcNAc) inhibitor, and to a manufacturing method thereof. By providing an effective compound for inhibiting OGT, the present invention can...

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1. Verfasser:	IM, JUNG KYUN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to C1-phosphonate derivatives of new uridine-5-diphosphate (UDP)-GlcNAc, which is effective for an O-linked N-acetylglucosamine (O-GlcNAc) inhibitor, and to a manufacturing method thereof. By providing an effective compound for inhibiting OGT, the present invention can be used as a useful instrument to study various vital phenomena by protein modification of O-GlcNAc in cells. Further, the present invention can be used as a candidate material for treating cancer, diabetes, and degenerative nerve diseases associated with protein modification of O-GlcNAc or for studying mechanisms thereof. 본 발명은 OGT(O-링크된 N-아세틸글루코사민 ; O-GlcNAc) 억제제로서 효과적인 새로운 유리딘-5'-다이포스페이트(uridine-5'-diphosphate ; UDP)-GlcNAc의 C1-포스페이트 유도체 및 이의 제조방법에 관한 것으로, OGT의 억제에 효과적인 화합물을 제공함으로써 세포내에서 O-GlcNAc의 단백질 변형에 의한 다양한 생명현상들을 연구하는데 유용한 도구가 될 것이며, 더 나아가 O-GlcNAc의 단백질 변형과 관련된 암, 당뇨병, 퇴행성 신경질환의 치료나 메커니즘 연구의 후보물질로 사용될 수 있다.