DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS
본 발명은 다이하이드로피리미딘 화합물 및 이의 약제학적 용도, 특히 HBV 질환을 치료 또는 예방하는데 사용하기 위한, 약제학적 용도를 제공한다. 구체적으로, 본 발명은 명세서에 정의된 바와 정의되는 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염을 제공한다. 또한, 본 발명은 HBV 질환을 치료 및 예방하기 위한, 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물,...
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| creator | ZOU ZHIFU GOLDMANN SIEGFRIED LIU XINCHANG REN QINGYUN LIANG JINSHENG ZHANG YINGJUN |
| description | 본 발명은 다이하이드로피리미딘 화합물 및 이의 약제학적 용도, 특히 HBV 질환을 치료 또는 예방하는데 사용하기 위한, 약제학적 용도를 제공한다. 구체적으로, 본 발명은 명세서에 정의된 바와 정의되는 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염을 제공한다. 또한, 본 발명은 HBV 질환을 치료 및 예방하기 위한, 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염의 용도를 제공한다.
Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_KR20160077050A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>KR20160077050A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_KR20160077050A3</originalsourceid><addsrcrecordid>eNrjZHBx8fSIdAnyD4gM8vT1dPH0c1Vw9vcN8A_1cwlWcPRzUQjxcPUMUnAMCPDxdHYM8fT3U_D0UwjwcAzydXR2DQ0BCvoE8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSSeO8gIwNDMwMDc3MDUwNHY-JUAQA5mSz0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS</title><source>esp@cenet</source><creator>ZOU ZHIFU ; GOLDMANN SIEGFRIED ; LIU XINCHANG ; REN QINGYUN ; LIANG JINSHENG ; ZHANG YINGJUN</creator><creatorcontrib>ZOU ZHIFU ; GOLDMANN SIEGFRIED ; LIU XINCHANG ; REN QINGYUN ; LIANG JINSHENG ; ZHANG YINGJUN</creatorcontrib><description>본 발명은 다이하이드로피리미딘 화합물 및 이의 약제학적 용도, 특히 HBV 질환을 치료 또는 예방하는데 사용하기 위한, 약제학적 용도를 제공한다. 구체적으로, 본 발명은 명세서에 정의된 바와 정의되는 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염을 제공한다. 또한, 본 발명은 HBV 질환을 치료 및 예방하기 위한, 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염의 용도를 제공한다.
Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.</description><language>eng ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160701&DB=EPODOC&CC=KR&NR=20160077050A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160701&DB=EPODOC&CC=KR&NR=20160077050A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZOU ZHIFU</creatorcontrib><creatorcontrib>GOLDMANN SIEGFRIED</creatorcontrib><creatorcontrib>LIU XINCHANG</creatorcontrib><creatorcontrib>REN QINGYUN</creatorcontrib><creatorcontrib>LIANG JINSHENG</creatorcontrib><creatorcontrib>ZHANG YINGJUN</creatorcontrib><title>DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS</title><description>본 발명은 다이하이드로피리미딘 화합물 및 이의 약제학적 용도, 특히 HBV 질환을 치료 또는 예방하는데 사용하기 위한, 약제학적 용도를 제공한다. 구체적으로, 본 발명은 명세서에 정의된 바와 정의되는 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염을 제공한다. 또한, 본 발명은 HBV 질환을 치료 및 예방하기 위한, 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염의 용도를 제공한다.
Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBx8fSIdAnyD4gM8vT1dPH0c1Vw9vcN8A_1cwlWcPRzUQjxcPUMUnAMCPDxdHYM8fT3U_D0UwjwcAzydXR2DQ0BCvoE8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSSeO8gIwNDMwMDc3MDUwNHY-JUAQA5mSz0</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>ZOU ZHIFU</creator><creator>GOLDMANN SIEGFRIED</creator><creator>LIU XINCHANG</creator><creator>REN QINGYUN</creator><creator>LIANG JINSHENG</creator><creator>ZHANG YINGJUN</creator><scope>EVB</scope></search><sort><creationdate>20160701</creationdate><title>DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS</title><author>ZOU ZHIFU ; GOLDMANN SIEGFRIED ; LIU XINCHANG ; REN QINGYUN ; LIANG JINSHENG ; ZHANG YINGJUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20160077050A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>ZOU ZHIFU</creatorcontrib><creatorcontrib>GOLDMANN SIEGFRIED</creatorcontrib><creatorcontrib>LIU XINCHANG</creatorcontrib><creatorcontrib>REN QINGYUN</creatorcontrib><creatorcontrib>LIANG JINSHENG</creatorcontrib><creatorcontrib>ZHANG YINGJUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZOU ZHIFU</au><au>GOLDMANN SIEGFRIED</au><au>LIU XINCHANG</au><au>REN QINGYUN</au><au>LIANG JINSHENG</au><au>ZHANG YINGJUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS</title><date>2016-07-01</date><risdate>2016</risdate><abstract>본 발명은 다이하이드로피리미딘 화합물 및 이의 약제학적 용도, 특히 HBV 질환을 치료 또는 예방하는데 사용하기 위한, 약제학적 용도를 제공한다. 구체적으로, 본 발명은 명세서에 정의된 바와 정의되는 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염을 제공한다. 또한, 본 발명은 HBV 질환을 치료 및 예방하기 위한, 식 (I) 또는 (Ia)를 가지는 화합물, 또는 이의 거울상 이성질체, 부분입체이성질체, 호변이성질체, 수화물, 용매화물 또는 약제학적으로 허용가능한 염의 용도를 제공한다.
Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS |
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