INHIBITORS OF TRANSCRIPTION FACTORS AND USES THEREOF
본 발명은 하기 화학식 I 내지 IV 중 임의의 것의 신규 화합물 및 그의 제약상 조성물을 제공한다. 화학식 I 내지 IV 중 임의의 것의 화합물은 브로모도메인-함유 단백질 (예를 들어, 브로모 및 말단외 단백질 (BET))의 억제제인 것으로 여겨진다. 브로모도메인-함유 단백질의 활성을 억제하기 위해, 및 브로모도메인-함유 단백질과 연관된 질환의 치료 및/또는 예방을 필요로 하는 대상체에서 브로모도메인-함유 단백질과 연관된 질환, 예컨대 증식성 질환을 치료 및/또는 예방하기 위해 본 발명의 화합물 및 제약 조성물을 사용하는 방법,...
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| creator | MARINEAU JASON J FU HARRY HONGNING MCKEOWN MICHAEL R BRADNER JAMES E QI JUN LIU SHUAI ZHANG WEI |
| description | 본 발명은 하기 화학식 I 내지 IV 중 임의의 것의 신규 화합물 및 그의 제약상 조성물을 제공한다. 화학식 I 내지 IV 중 임의의 것의 화합물은 브로모도메인-함유 단백질 (예를 들어, 브로모 및 말단외 단백질 (BET))의 억제제인 것으로 여겨진다. 브로모도메인-함유 단백질의 활성을 억제하기 위해, 및 브로모도메인-함유 단백질과 연관된 질환의 치료 및/또는 예방을 필요로 하는 대상체에서 브로모도메인-함유 단백질과 연관된 질환, 예컨대 증식성 질환을 치료 및/또는 예방하기 위해 본 발명의 화합물 및 제약 조성물을 사용하는 방법, 용도 및 키트가 또한 제공된다.
The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae (I) to (IV) are believed to be inhibitors of bromodomain-containing proteins (e.g., bromo and extra terminal proteins (BETs)). Also provided are methods, uses, and kits using the inventive compounds and pharmaceutical compositions for inhibiting the activity of the bromodomain-containing proteins and for treating and/or preventing in a subject in need thereof diseases associated with bromodomain-containing proteins, such as proliferative diseases. |
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The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae (I) to (IV) are believed to be inhibitors of bromodomain-containing proteins (e.g., bromo and extra terminal proteins (BETs)). Also provided are methods, uses, and kits using the inventive compounds and pharmaceutical compositions for inhibiting the activity of the bromodomain-containing proteins and for treating and/or preventing in a subject in need thereof diseases associated with bromodomain-containing proteins, such as proliferative diseases.</description><language>eng ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; TESTING</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160329&DB=EPODOC&CC=KR&NR=20160034379A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160329&DB=EPODOC&CC=KR&NR=20160034379A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MARINEAU JASON J</creatorcontrib><creatorcontrib>FU HARRY HONGNING</creatorcontrib><creatorcontrib>MCKEOWN MICHAEL R</creatorcontrib><creatorcontrib>BRADNER JAMES E</creatorcontrib><creatorcontrib>QI JUN</creatorcontrib><creatorcontrib>LIU SHUAI</creatorcontrib><creatorcontrib>ZHANG WEI</creatorcontrib><title>INHIBITORS OF TRANSCRIPTION FACTORS AND USES THEREOF</title><description>본 발명은 하기 화학식 I 내지 IV 중 임의의 것의 신규 화합물 및 그의 제약상 조성물을 제공한다. 화학식 I 내지 IV 중 임의의 것의 화합물은 브로모도메인-함유 단백질 (예를 들어, 브로모 및 말단외 단백질 (BET))의 억제제인 것으로 여겨진다. 브로모도메인-함유 단백질의 활성을 억제하기 위해, 및 브로모도메인-함유 단백질과 연관된 질환의 치료 및/또는 예방을 필요로 하는 대상체에서 브로모도메인-함유 단백질과 연관된 질환, 예컨대 증식성 질환을 치료 및/또는 예방하기 위해 본 발명의 화합물 및 제약 조성물을 사용하는 방법, 용도 및 키트가 또한 제공된다. <화학식 I><화학식 II><화학식 III><화학식 IV>
The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae (I) to (IV) are believed to be inhibitors of bromodomain-containing proteins (e.g., bromo and extra terminal proteins (BETs)). Also provided are methods, uses, and kits using the inventive compounds and pharmaceutical compositions for inhibiting the activity of the bromodomain-containing proteins and for treating and/or preventing in a subject in need thereof diseases associated with bromodomain-containing proteins, such as proliferative diseases.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDx9PPwdPIM8Q8KVvB3UwgJcvQLdg7yDAjx9PdTcHN0Bks4-rkohAa7BiuEeLgGufq78TCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSSeO8gIwNDMwMDYxNjc0tHY-JUAQB7Rihv</recordid><startdate>20160329</startdate><enddate>20160329</enddate><creator>MARINEAU JASON J</creator><creator>FU HARRY HONGNING</creator><creator>MCKEOWN MICHAEL R</creator><creator>BRADNER JAMES E</creator><creator>QI JUN</creator><creator>LIU SHUAI</creator><creator>ZHANG WEI</creator><scope>EVB</scope></search><sort><creationdate>20160329</creationdate><title>INHIBITORS OF TRANSCRIPTION FACTORS AND USES THEREOF</title><author>MARINEAU JASON J ; FU HARRY HONGNING ; MCKEOWN MICHAEL R ; BRADNER JAMES E ; QI JUN ; LIU SHUAI ; ZHANG WEI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20160034379A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>MARINEAU JASON J</creatorcontrib><creatorcontrib>FU HARRY HONGNING</creatorcontrib><creatorcontrib>MCKEOWN MICHAEL R</creatorcontrib><creatorcontrib>BRADNER JAMES E</creatorcontrib><creatorcontrib>QI JUN</creatorcontrib><creatorcontrib>LIU SHUAI</creatorcontrib><creatorcontrib>ZHANG WEI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MARINEAU JASON J</au><au>FU HARRY HONGNING</au><au>MCKEOWN MICHAEL R</au><au>BRADNER JAMES E</au><au>QI JUN</au><au>LIU SHUAI</au><au>ZHANG WEI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITORS OF TRANSCRIPTION FACTORS AND USES THEREOF</title><date>2016-03-29</date><risdate>2016</risdate><abstract>본 발명은 하기 화학식 I 내지 IV 중 임의의 것의 신규 화합물 및 그의 제약상 조성물을 제공한다. 화학식 I 내지 IV 중 임의의 것의 화합물은 브로모도메인-함유 단백질 (예를 들어, 브로모 및 말단외 단백질 (BET))의 억제제인 것으로 여겨진다. 브로모도메인-함유 단백질의 활성을 억제하기 위해, 및 브로모도메인-함유 단백질과 연관된 질환의 치료 및/또는 예방을 필요로 하는 대상체에서 브로모도메인-함유 단백질과 연관된 질환, 예컨대 증식성 질환을 치료 및/또는 예방하기 위해 본 발명의 화합물 및 제약 조성물을 사용하는 방법, 용도 및 키트가 또한 제공된다. <화학식 I><화학식 II><화학식 III><화학식 IV>
The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae (I) to (IV) are believed to be inhibitors of bromodomain-containing proteins (e.g., bromo and extra terminal proteins (BETs)). Also provided are methods, uses, and kits using the inventive compounds and pharmaceutical compositions for inhibiting the activity of the bromodomain-containing proteins and for treating and/or preventing in a subject in need thereof diseases associated with bromodomain-containing proteins, such as proliferative diseases.</abstract><oa>free_for_read</oa></addata></record> |
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| title | INHIBITORS OF TRANSCRIPTION FACTORS AND USES THEREOF |
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