ANTIBODY AND METHODS FOR SELECTIVE INHIBITION OF T-CELL RESPONSES
The present invention provides compositions, methods, and assays for treating an inflammatory and/or autoimmune disease, and/or transplanted tissue rejection using anti-α TCR antibodies and antibody fragments. Anti-α TCR antibodies are antibodies which bind to a α TCR. Anti-α TCR antibodies produced...
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| creator | PUISIS JOHN JAMES HERRMANN JAMES JOSEPH FOKTA FRANK J GETTS DANIEL RICHARDT |
| description | The present invention provides compositions, methods, and assays for treating an inflammatory and/or autoimmune disease, and/or transplanted tissue rejection using anti-α TCR antibodies and antibody fragments. Anti-α TCR antibodies are antibodies which bind to a α TCR. Anti-α TCR antibodies produced by the hybridoma TOL101 MCB are also provided. Methods for treatment of an inflammatory disease, an autoimmune disease and for tissue transplant rejection using therapeutic dosing regimen of anti-α TCR antibodies and antibody fragments and for upregulating the numbers of Treg T-cells are also provided |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTIBODY AND METHODS FOR SELECTIVE INHIBITION OF T-CELL RESPONSES |
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