ANTIBODY VARIANT WITH CYSTEINE RESIDUES, ANTIBODY-DRUG CONJUGATE COMPRISING THE ANTIBODY VARIANT, AND METHOD OF MANUFACTURING THEREOF

ANTIBODY VARIANT WITH CYSTEINE RESIDUES, ANTIBODY-DRUG CONJUGATE COMPRISING THE ANTIBODY VARIANT, AND METHOD OF MANUFACTURING THEREOF

PURPOSE: An antibody variant-drug conjugate (mADC) is provided to accurately transfer a drug to target cells with high specificity of an antibody and to enhance treatment effect. CONSTITUTION: An antibody variant is prepared by conjugating a motif containing a cysteine residue of structural formula...

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Hauptverfasser: CHUNG, HYE SHIN, KIM, YONG MO, KWON, SUN HOON, YOU, SUN AH, PARK, SOON JAE, LEE, SUN BAE
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Sprache:eng ; kor
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator CHUNG, HYE SHIN
KIM, YONG MO
KWON, SUN HOON
YOU, SUN AH
PARK, SOON JAE
LEE, SUN BAE
description PURPOSE: An antibody variant-drug conjugate (mADC) is provided to accurately transfer a drug to target cells with high specificity of an antibody and to enhance treatment effect. CONSTITUTION: An antibody variant is prepared by conjugating a motif containing a cysteine residue of structural formula 1 (Xa-[(M_Cys)_n-Xb_n]_n) at the end of a parent antibody. An antibody-drug conjugate contains the antibody variant conjugated with a drug by a thiol group of the cysteine residue. [Reference numerals] (AA) UV-VIS absorbance
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title ANTIBODY VARIANT WITH CYSTEINE RESIDUES, ANTIBODY-DRUG CONJUGATE COMPRISING THE ANTIBODY VARIANT, AND METHOD OF MANUFACTURING THEREOF
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