CANCER THERAPY METHOD

CANCER THERAPY METHOD

This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD...

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Hauptverfasser: FERNANDEZ MASSO JULIO RAUL, OLIVA ARGUELLES BRIZAIDA MAYLIN, GUERRA VALLESPI MARIBEL, MUSACCHIO LASA ALEXIS, GIL VALDES JEOVANIS, REYES ACOSTA OSVALDO
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Sprache:eng ; kor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator FERNANDEZ MASSO JULIO RAUL
OLIVA ARGUELLES BRIZAIDA MAYLIN
GUERRA VALLESPI MARIBEL
MUSACCHIO LASA ALEXIS
GIL VALDES JEOVANIS
REYES ACOSTA OSVALDO
description This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title CANCER THERAPY METHOD
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