HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an a...
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| creator | VENTURINI AMY TRACEY DANIEL E KAYMAKCALAN ZEHRA VELDMAN GEERTRUIDA M WIDOM ANGELA DUNCAN ALEXANDER R WHITE MICHAEL SMITH STEPHEN SAKORAFAS PAUL DU FOU SARAH L SALFELD JOCHEN G MYLES ANGELA FRIEDRICH STUART ROGUSKA MICHAEL ELVIN JOHN G PASKIND MICHAEL LABKOVSKY BORIS DERBYSHIRE ELAINE J BANERJEE SUBHASHIS WARNE NICHOLAS W CARMEN SARA HOLTET THOR LAS |
| description | Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. |
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Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.</description><language>eng ; kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120817&DB=EPODOC&CC=KR&NR=20120091477A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120817&DB=EPODOC&CC=KR&NR=20120091477A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VENTURINI AMY</creatorcontrib><creatorcontrib>TRACEY DANIEL E</creatorcontrib><creatorcontrib>KAYMAKCALAN ZEHRA</creatorcontrib><creatorcontrib>VELDMAN GEERTRUIDA M</creatorcontrib><creatorcontrib>WIDOM ANGELA</creatorcontrib><creatorcontrib>DUNCAN ALEXANDER R</creatorcontrib><creatorcontrib>WHITE MICHAEL</creatorcontrib><creatorcontrib>SMITH STEPHEN</creatorcontrib><creatorcontrib>SAKORAFAS PAUL</creatorcontrib><creatorcontrib>DU FOU SARAH L</creatorcontrib><creatorcontrib>SALFELD JOCHEN G</creatorcontrib><creatorcontrib>MYLES ANGELA</creatorcontrib><creatorcontrib>FRIEDRICH STUART</creatorcontrib><creatorcontrib>ROGUSKA MICHAEL</creatorcontrib><creatorcontrib>ELVIN JOHN G</creatorcontrib><creatorcontrib>PASKIND MICHAEL</creatorcontrib><creatorcontrib>LABKOVSKY BORIS</creatorcontrib><creatorcontrib>DERBYSHIRE ELAINE J</creatorcontrib><creatorcontrib>BANERJEE SUBHASHIS</creatorcontrib><creatorcontrib>WARNE NICHOLAS W</creatorcontrib><creatorcontrib>CARMEN SARA</creatorcontrib><creatorcontrib>HOLTET THOR LAS</creatorcontrib><title>HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING</title><description>Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDwCPV19FNw9AvxdPJ38XQNVgjxcAxRcPL0c1GASHn66BoaARW4KPi6hnj4uwQruPkHKQQE-buEOnv6ufMwsKYl5hSn8kJpbgZlN9cQZw_d1IL8-NTigsTk1LzUknjvICMDQyMDA0tDE3NzR2PiVAEABtAq5Q</recordid><startdate>20120817</startdate><enddate>20120817</enddate><creator>VENTURINI AMY</creator><creator>TRACEY DANIEL E</creator><creator>KAYMAKCALAN ZEHRA</creator><creator>VELDMAN GEERTRUIDA M</creator><creator>WIDOM ANGELA</creator><creator>DUNCAN ALEXANDER R</creator><creator>WHITE MICHAEL</creator><creator>SMITH STEPHEN</creator><creator>SAKORAFAS PAUL</creator><creator>DU FOU SARAH L</creator><creator>SALFELD JOCHEN G</creator><creator>MYLES ANGELA</creator><creator>FRIEDRICH STUART</creator><creator>ROGUSKA MICHAEL</creator><creator>ELVIN JOHN G</creator><creator>PASKIND MICHAEL</creator><creator>LABKOVSKY BORIS</creator><creator>DERBYSHIRE ELAINE J</creator><creator>BANERJEE SUBHASHIS</creator><creator>WARNE NICHOLAS W</creator><creator>CARMEN SARA</creator><creator>HOLTET THOR LAS</creator><scope>EVB</scope></search><sort><creationdate>20120817</creationdate><title>HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING</title><author>VENTURINI AMY ; 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Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING |
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