HIGHLY ENANTIOSELECTIVE BIFUNCTIONAL ORGANOCATALYSTS, PREPARATION METHOD THEREOF, AND METHOD FOR PREPARING CHIRAL AMINO ACID FROM AZLACTONES USING THE SAME

HIGHLY ENANTIOSELECTIVE BIFUNCTIONAL ORGANOCATALYSTS, PREPARATION METHOD THEREOF, AND METHOD FOR PREPARING CHIRAL AMINO ACID FROM AZLACTONES USING THE SAME

PURPOSE: A method for preparing chiral amino acid ester having high stereoselectivity is provided to economically and simply produce N-acyl amino acid ester of highly optical selectivity. CONSTITUTION: A bifunctional organic chiral catalyst compound is denoted by chemical formula 1. A method for pre...

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Bibliographische Detailangaben
Hauptverfasser: LEE, JI WOONG, SONG, CHOON GEUI, BAE, HAN YONG, RYU, TAE HI, OH, JOONG SUK
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PURPOSE: A method for preparing chiral amino acid ester having high stereoselectivity is provided to economically and simply produce N-acyl amino acid ester of highly optical selectivity. CONSTITUTION: A bifunctional organic chiral catalyst compound is denoted by chemical formula 1. A method for preparing the bifunctional chiral organic catalyst comprises a step of reacting amine with 3,4-alkoxy-3-cyclobutene-1,2-dione derivative. A chiral N-acyl amino acid ester is prepared from azlactone by reacting racemic azlactone, (S)-azlactone or (R)-azlactoen with nucleophile under the presence of organic solvent.