THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR
This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of...
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| creator | HOSTOMSKY ZDENEK JONES CHRISTOPHER STEINFELDT HEIDI MARIE CURTIN NICOLA JANE CALVERT ALAN HILARY BORITZKI THEODORE JAMES THOMAS HUW DAVID DEWJI MOHAMED RAZA KLAMERUS KAREN J NEWELL DAVID RICHARD WILLIAMS KAYE JANINE KAUFMAN RHONDA REICH STEVEN DAVID STRATFORD IAN J PLUMMER ELIZABETH RUTH |
| description | This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer. |
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This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070502&DB=EPODOC&CC=KR&NR=20070046183A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070502&DB=EPODOC&CC=KR&NR=20070046183A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HOSTOMSKY ZDENEK</creatorcontrib><creatorcontrib>JONES CHRISTOPHER</creatorcontrib><creatorcontrib>STEINFELDT HEIDI MARIE</creatorcontrib><creatorcontrib>CURTIN NICOLA JANE</creatorcontrib><creatorcontrib>CALVERT ALAN HILARY</creatorcontrib><creatorcontrib>BORITZKI THEODORE JAMES</creatorcontrib><creatorcontrib>THOMAS HUW DAVID</creatorcontrib><creatorcontrib>DEWJI MOHAMED RAZA</creatorcontrib><creatorcontrib>KLAMERUS KAREN J</creatorcontrib><creatorcontrib>NEWELL DAVID RICHARD</creatorcontrib><creatorcontrib>WILLIAMS KAYE JANINE</creatorcontrib><creatorcontrib>KAUFMAN RHONDA</creatorcontrib><creatorcontrib>REICH STEVEN DAVID</creatorcontrib><creatorcontrib>STRATFORD IAN J</creatorcontrib><creatorcontrib>PLUMMER ELIZABETH RUTH</creatorcontrib><title>THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR</title><description>This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAK8XANcgxwDQ3xdFZw9vd18vRzDPH09wsGcQKCPIM9_dwVAvx9IjUcXQJ0gzyd_INdNcECvkB9wa7BCp5-Hp5OniH-QTwMrGmJOcWpvFCam0HZzTXE2UM3tSA_PrW4IDE5NS-1JN47yMjAwNzAwMTM0MLY0Zg4VQBXjC7B</recordid><startdate>20070502</startdate><enddate>20070502</enddate><creator>HOSTOMSKY ZDENEK</creator><creator>JONES CHRISTOPHER</creator><creator>STEINFELDT HEIDI MARIE</creator><creator>CURTIN NICOLA JANE</creator><creator>CALVERT ALAN HILARY</creator><creator>BORITZKI THEODORE JAMES</creator><creator>THOMAS HUW DAVID</creator><creator>DEWJI MOHAMED RAZA</creator><creator>KLAMERUS KAREN J</creator><creator>NEWELL DAVID RICHARD</creator><creator>WILLIAMS KAYE JANINE</creator><creator>KAUFMAN RHONDA</creator><creator>REICH STEVEN DAVID</creator><creator>STRATFORD IAN J</creator><creator>PLUMMER ELIZABETH RUTH</creator><scope>EVB</scope></search><sort><creationdate>20070502</creationdate><title>THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR</title><author>HOSTOMSKY ZDENEK ; JONES CHRISTOPHER ; STEINFELDT HEIDI MARIE ; CURTIN NICOLA JANE ; CALVERT ALAN HILARY ; BORITZKI THEODORE JAMES ; THOMAS HUW DAVID ; DEWJI MOHAMED RAZA ; KLAMERUS KAREN J ; NEWELL DAVID RICHARD ; WILLIAMS KAYE JANINE ; KAUFMAN RHONDA ; REICH STEVEN DAVID ; STRATFORD IAN J ; PLUMMER ELIZABETH RUTH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20070046183A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2007</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HOSTOMSKY ZDENEK</creatorcontrib><creatorcontrib>JONES CHRISTOPHER</creatorcontrib><creatorcontrib>STEINFELDT HEIDI MARIE</creatorcontrib><creatorcontrib>CURTIN NICOLA JANE</creatorcontrib><creatorcontrib>CALVERT ALAN HILARY</creatorcontrib><creatorcontrib>BORITZKI THEODORE JAMES</creatorcontrib><creatorcontrib>THOMAS HUW DAVID</creatorcontrib><creatorcontrib>DEWJI MOHAMED RAZA</creatorcontrib><creatorcontrib>KLAMERUS KAREN J</creatorcontrib><creatorcontrib>NEWELL DAVID RICHARD</creatorcontrib><creatorcontrib>WILLIAMS KAYE JANINE</creatorcontrib><creatorcontrib>KAUFMAN RHONDA</creatorcontrib><creatorcontrib>REICH STEVEN DAVID</creatorcontrib><creatorcontrib>STRATFORD IAN J</creatorcontrib><creatorcontrib>PLUMMER ELIZABETH RUTH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HOSTOMSKY ZDENEK</au><au>JONES CHRISTOPHER</au><au>STEINFELDT HEIDI MARIE</au><au>CURTIN NICOLA JANE</au><au>CALVERT ALAN HILARY</au><au>BORITZKI THEODORE JAMES</au><au>THOMAS HUW DAVID</au><au>DEWJI MOHAMED RAZA</au><au>KLAMERUS KAREN J</au><au>NEWELL DAVID RICHARD</au><au>WILLIAMS KAYE JANINE</au><au>KAUFMAN RHONDA</au><au>REICH STEVEN DAVID</au><au>STRATFORD IAN J</au><au>PLUMMER ELIZABETH RUTH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR</title><date>2007-05-02</date><risdate>2007</risdate><abstract>This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR |
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