PREPARATION METHOD OF 2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE

PREPARATION METHOD OF 2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE

A preparation method of 2-(2-aminoethyl)-1-methylpyrrolidine is provided to reduce the preparation costs by using inexpensive starting materials, and improve preparation yield by efficiently hydrogenating the intermediate. The preparation method of 2-(2-aminoethyl)-1-methylpyrrolidine represented by...

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Bibliographische Detailangaben
Hauptverfasser: YOON, HEUNG SIK, RYU, TAE HI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A preparation method of 2-(2-aminoethyl)-1-methylpyrrolidine is provided to reduce the preparation costs by using inexpensive starting materials, and improve preparation yield by efficiently hydrogenating the intermediate. The preparation method of 2-(2-aminoethyl)-1-methylpyrrolidine represented by the formula(1) comprises the steps of: reacting 1-methyl-2-pyrrolidinone with dimethylsulfate to prepare compounds represented by the formula(2); reacting the compounds represented by the formula(2) with methylcyano acetate to prepare ester compounds represented by the formula(3); decarboxylating the ester compounds represented by the formula(3) to prepare acetonitrile compounds represented by the formula(4); reacting the acetonitrile compounds represented by the formula(4) with acid to prepare acid salt represented by the formula(5); and hydrogenating the acid salt represented by the formula(5), wherein HA is inorganic acid or organic acid.