ESTER COMPOUND AND MEDICINAL USE THEREOF
A novel therapeutic agent for hyperlipemia which is an ester compound represented by the general formula (1"): (1") [wherein R1 and R2 each is hydrogen, optionally substituted aryl, etc.; X is -COO- or - CON(R10)-; R3 and R 4 each is hydrogen, C1- 6 alkyl, C1-6 alkoxy, etc.; R5, R6, and R7...
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| creator | MADONO KENYA IKENOGAMI TAKU TANIGUCHI TOSHIO ODANI NAOYA HAGIWARA ATSUSHI OE YASUHIRO WATANABE SHIZUE KAWAI TAKASHI |
| description | A novel therapeutic agent for hyperlipemia which is an ester compound represented by the general formula (1"): (1") [wherein R1 and R2 each is hydrogen, optionally substituted aryl, etc.; X is -COO- or - CON(R10)-; R3 and R 4 each is hydrogen, C1- 6 alkyl, C1-6 alkoxy, etc.; R5, R6, and R7 each is hydrogen, C1-6 alkyl, C1-6 alkoxy, etc.; R8 and R 9 are the same or different and each is hydrogen, C1-6 alkyl, - CON(R18)(R19), -COO(R20), etc.; rings A, B, and C are the same or different and each is aryl, a heterocycle residue, etc.; Alk1 and Alk2 are the same or different and each is alkanediyl, etc.; and l and m each is an integer of 0 to 3], a prodrug of the ester compound, or a pharmaceutically acceptable salt of either. The therapeutic agent selectively inhibits MTP in the small intestine and hence causes no side effects such as a fatty liver. |
| format | Patent |
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The therapeutic agent selectively inhibits MTP in the small intestine and hence causes no side effects such as a fatty liver.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ESTER COMPOUND AND MEDICINAL USE THEREOF |
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