RECOMBINANT PROTEINS COMPRISING BOTULINUM TOXIN AND CELL PENETRATING PEPTIDE AND COSMETIC COMPOSITION COMPRISING THEREOF

The present invention relates to a recombinant protein comprising a botulinum toxin and a cell-permeable peptide, and a cosmetic composition comprising the same. The cell-permeable peptide according to the present invention allows more efficient skin penetration and/or cell penetration of the botuli...

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Bibliographische Detailangaben
Hauptverfasser:	PARK HYUNSUN, PARK TAEKYU, WONSUP CHOI, KWON DASOM
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a recombinant protein comprising a botulinum toxin and a cell-permeable peptide, and a cosmetic composition comprising the same. The cell-permeable peptide according to the present invention allows more efficient skin penetration and/or cell penetration of the botulinum toxin. Thus, through a cell-permeable recombinant protein obtained by fusing the botulinum toxin and the cell-permeable peptide, the intrinsic efficacy of the botulinum toxin in vivo can be maximized. Also, enhanced convenience is ensured. Accordingly, the recombinant protein can be actively used as a topical agent, especially a cosmetic composition, for the treatment of various diseases or for the aesthetic or cosmetic purposes. 본 발명은 보툴리눔 독소 및 세포 투과성 펩타이드를 포함하는 재조합 단백질과 이를 포함하는 화장료 조성물에 관한 것이다. 본 발명에 따른 세포 투과성 펩타이드는 보다 보툴리눔 독소에 대한 피부 투과 및/또는 세포 투과를 효율적으로 진행되도록 함으로써 상기 보툴리눔 독소와 세포 투과성 펩타이드를 융합한 세포 투과성 재조합 단백질을 통하여, 상기 보툴리눔 독소의 생체 내에서의 고유 효능을 극대화시킬 수 있는 동시에 보다 편의성을 확보함으로써, 다양한 질환 치료, 심미 또는 미용 목적을 위한 국소 작용제, 특히 화장품 조성물로 적극 활용될 수 있다.