DUAL IONIC CROSSLINKED INTERPENETRATING NETWORK OF ALGINATE-CELLULOSE BEADS AND PREPARATION METHOD THEREOF
According to the present invention, tissue-engineered hydrogel beads with improved mechanical properties can be simply and effectively produced by forming a secondary network of biocompatible negative ionic cellulose within a primary network of alginate to form an interpenetrating network (IPN). The...
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| creator | HONG, JI SU CHA, CHAE NYUNG LEE, KANG SEOK |
| description | According to the present invention, tissue-engineered hydrogel beads with improved mechanical properties can be simply and effectively produced by forming a secondary network of biocompatible negative ionic cellulose within a primary network of alginate to form an interpenetrating network (IPN). The hydrogel beads of the present invention have extremely high mechanical strength compared to existing hydrogel beads, allow users to control the stiffness, and exhibit excellent durability against a harsh chemical environment. Also, microorganisms species is encapsulated by using the hydrogel beads for the biomedical application thereof, and thus biological activity and a therapeutic effect of the hydrogel beads can be maximized compared to existing hydrogel beads.
본 발명에 따르면, 알지네이트의 1차 네트워크 내에 생체적합성 음이온성 셀룰로오스의 2차 네트워크를 형성하여 상호침투 네트워크(IPN)을 형성함으로써, 기계적 특성이 향상된 조직공학적 하이드로겔 비드를 간단하고도 효과적으로 제조할 수 있다. 상기 하이드로겔 비드는 종래보다 기계적 강도가 매우 높고 강성도를 제어가능할 뿐만 아니라 가혹한 화학적 환경에 대한 내구성이 우수하다. 또한, 상기 하이드로겔 비드에 의해 생의학적 응용을 위해 미생물종을 캡슐화하여 종래보다 생물학적 활성과 치료 효과를 극대화할 수 있다. |
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본 발명에 따르면, 알지네이트의 1차 네트워크 내에 생체적합성 음이온성 셀룰로오스의 2차 네트워크를 형성하여 상호침투 네트워크(IPN)을 형성함으로써, 기계적 특성이 향상된 조직공학적 하이드로겔 비드를 간단하고도 효과적으로 제조할 수 있다. 상기 하이드로겔 비드는 종래보다 기계적 강도가 매우 높고 강성도를 제어가능할 뿐만 아니라 가혹한 화학적 환경에 대한 내구성이 우수하다. 또한, 상기 하이드로겔 비드에 의해 생의학적 응용을 위해 미생물종을 캡슐화하여 종래보다 생물학적 활성과 치료 효과를 극대화할 수 있다.</description><language>eng ; kor</language><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181214&DB=EPODOC&CC=KR&NR=101929293B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181214&DB=EPODOC&CC=KR&NR=101929293B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HONG, JI SU</creatorcontrib><creatorcontrib>CHA, CHAE NYUNG</creatorcontrib><creatorcontrib>LEE, KANG SEOK</creatorcontrib><title>DUAL IONIC CROSSLINKED INTERPENETRATING NETWORK OF ALGINATE-CELLULOSE BEADS AND PREPARATION METHOD THEREOF</title><description>According to the present invention, tissue-engineered hydrogel beads with improved mechanical properties can be simply and effectively produced by forming a secondary network of biocompatible negative ionic cellulose within a primary network of alginate to form an interpenetrating network (IPN). The hydrogel beads of the present invention have extremely high mechanical strength compared to existing hydrogel beads, allow users to control the stiffness, and exhibit excellent durability against a harsh chemical environment. Also, microorganisms species is encapsulated by using the hydrogel beads for the biomedical application thereof, and thus biological activity and a therapeutic effect of the hydrogel beads can be maximized compared to existing hydrogel beads.
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본 발명에 따르면, 알지네이트의 1차 네트워크 내에 생체적합성 음이온성 셀룰로오스의 2차 네트워크를 형성하여 상호침투 네트워크(IPN)을 형성함으로써, 기계적 특성이 향상된 조직공학적 하이드로겔 비드를 간단하고도 효과적으로 제조할 수 있다. 상기 하이드로겔 비드는 종래보다 기계적 강도가 매우 높고 강성도를 제어가능할 뿐만 아니라 가혹한 화학적 환경에 대한 내구성이 우수하다. 또한, 상기 하이드로겔 비드에 의해 생의학적 응용을 위해 미생물종을 캡슐화하여 종래보다 생물학적 활성과 치료 효과를 극대화할 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | DUAL IONIC CROSSLINKED INTERPENETRATING NETWORK OF ALGINATE-CELLULOSE BEADS AND PREPARATION METHOD THEREOF |
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