A PH RESPONSIVE CYCLODEXTRIN DERIVATIVE, A PREPARATION METHOD THEROF AND A PH RESPONSIVE CONJUGATE OF THE CYCLODEXTRIN DERIVATIVE AND A DRUG
The present invention relates to a pH-responsive cyclodextrin derivative, a preparation method thereof, and a pH-responsive conjugate of the pH-responsive cyclodextrin derivative and a drug, and more specifically, to a cyclodextrin derivative having a novel structure, a preparation method thereof, a...
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| creator | SONG, YOUNG JUN PARK, EU DDEUM KANG, SUN YOUNG PIAOYINGLAN KIM, SUK WHA LEE, YAN CHOI, JAE HOON KIM, YOUNG EUN HUR, WOO JUNE CHOI, TAE HYUN MIN, HYE JEONG CHOI, LA MEE |
| description | The present invention relates to a pH-responsive cyclodextrin derivative, a preparation method thereof, and a pH-responsive conjugate of the pH-responsive cyclodextrin derivative and a drug, and more specifically, to a cyclodextrin derivative having a novel structure, a preparation method thereof, and a pH-responsive conjugate of the pH-responsive cyclodextrin derivative and a drug. The cyclodextrin derivative has a novel structure formed by a covalent bond between a maleic anhydride derivative and a cyclodextrin or a cyclodextrin derivative, in which a residue of the maleic anhydride derivative bonds to a primary hydroxyl group of cyclodextrin or a terminal functional group, such as NH_2, N_3, or amino acid, of a cyclodextrin derivative to produce a pH-responsive cyclodextrin derivative.
본 발명은 pH 응답성 사이클로덱스트린 유도체, 이의 제조방법 및 상기 사이클로덱스트린 유도체와 약물의 pH 응답성 결합체에 관한 것으로, 더욱 상세하게는 사이클로덱스트린 또는 이의 유도체와 말레산 무수물 유도체의 공유 결합에 의해 형성된 새로운 구조의 사이클로덱스트린 유도체로서, 사이클로덱스트린의 일차 히드록실기 또는 사이클로덱스트린 유도체의 NH, N또는 아미노산과 같은 말단 작용기에 말레산 무수물 유도체 잔기가 결합되어 형성되는 pH 응답성 사이클로덱스트린 유도체, 이의 제조방법 및 상기 사이클로덱스트린 유도체와 약물의 pH 응답성 결합체에 관한 것이다. |
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본 발명은 pH 응답성 사이클로덱스트린 유도체, 이의 제조방법 및 상기 사이클로덱스트린 유도체와 약물의 pH 응답성 결합체에 관한 것으로, 더욱 상세하게는 사이클로덱스트린 또는 이의 유도체와 말레산 무수물 유도체의 공유 결합에 의해 형성된 새로운 구조의 사이클로덱스트린 유도체로서, 사이클로덱스트린의 일차 히드록실기 또는 사이클로덱스트린 유도체의 NH, N또는 아미노산과 같은 말단 작용기에 말레산 무수물 유도체 잔기가 결합되어 형성되는 pH 응답성 사이클로덱스트린 유도체, 이의 제조방법 및 상기 사이클로덱스트린 유도체와 약물의 pH 응답성 결합체에 관한 것이다.</description><language>eng ; kor</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; POLYSACCHARIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160520&DB=EPODOC&CC=KR&NR=101622851B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160520&DB=EPODOC&CC=KR&NR=101622851B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SONG, YOUNG JUN</creatorcontrib><creatorcontrib>PARK, EU DDEUM</creatorcontrib><creatorcontrib>KANG, SUN YOUNG</creatorcontrib><creatorcontrib>PIAOYINGLAN</creatorcontrib><creatorcontrib>KIM, SUK WHA</creatorcontrib><creatorcontrib>LEE, YAN</creatorcontrib><creatorcontrib>CHOI, JAE HOON</creatorcontrib><creatorcontrib>KIM, YOUNG EUN</creatorcontrib><creatorcontrib>HUR, WOO JUNE</creatorcontrib><creatorcontrib>CHOI, TAE HYUN</creatorcontrib><creatorcontrib>MIN, HYE JEONG</creatorcontrib><creatorcontrib>CHOI, LA MEE</creatorcontrib><title>A PH RESPONSIVE CYCLODEXTRIN DERIVATIVE, A PREPARATION METHOD THEROF AND A PH RESPONSIVE CONJUGATE OF THE CYCLODEXTRIN DERIVATIVE AND A DRUG</title><description>The present invention relates to a pH-responsive cyclodextrin derivative, a preparation method thereof, and a pH-responsive conjugate of the pH-responsive cyclodextrin derivative and a drug, and more specifically, to a cyclodextrin derivative having a novel structure, a preparation method thereof, and a pH-responsive conjugate of the pH-responsive cyclodextrin derivative and a drug. The cyclodextrin derivative has a novel structure formed by a covalent bond between a maleic anhydride derivative and a cyclodextrin or a cyclodextrin derivative, in which a residue of the maleic anhydride derivative bonds to a primary hydroxyl group of cyclodextrin or a terminal functional group, such as NH_2, N_3, or amino acid, of a cyclodextrin derivative to produce a pH-responsive cyclodextrin derivative.
본 발명은 pH 응답성 사이클로덱스트린 유도체, 이의 제조방법 및 상기 사이클로덱스트린 유도체와 약물의 pH 응답성 결합체에 관한 것으로, 더욱 상세하게는 사이클로덱스트린 또는 이의 유도체와 말레산 무수물 유도체의 공유 결합에 의해 형성된 새로운 구조의 사이클로덱스트린 유도체로서, 사이클로덱스트린의 일차 히드록실기 또는 사이클로덱스트린 유도체의 NH, N또는 아미노산과 같은 말단 작용기에 말레산 무수물 유도체 잔기가 결합되어 형성되는 pH 응답성 사이클로덱스트린 유도체, 이의 제조방법 및 상기 사이클로덱스트린 유도체와 약물의 pH 응답성 결합체에 관한 것이다.</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>POLYSACCHARIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOhxVAjwUAhyDQ7w9wv2DHNVcI509vF3cY0ICfL0U3BxDfIMcwwBiusoABUGuQY4BgG5_n4Kvq4hHv4uCiEerkH-bgqOfi4KGAb5-3mFujuGuCoAFQDV4TIZqtklKNSdh4E1LTGnOJUXSnMzKLu5hjh76KYW5MenFhckJqfmpZbEewcZGhiaGRlZmBo6ORkaE6cKAD3MQDk</recordid><startdate>20160520</startdate><enddate>20160520</enddate><creator>SONG, YOUNG JUN</creator><creator>PARK, EU DDEUM</creator><creator>KANG, SUN YOUNG</creator><creator>PIAOYINGLAN</creator><creator>KIM, SUK WHA</creator><creator>LEE, YAN</creator><creator>CHOI, JAE HOON</creator><creator>KIM, YOUNG EUN</creator><creator>HUR, WOO JUNE</creator><creator>CHOI, TAE HYUN</creator><creator>MIN, HYE JEONG</creator><creator>CHOI, LA MEE</creator><scope>EVB</scope></search><sort><creationdate>20160520</creationdate><title>A PH RESPONSIVE CYCLODEXTRIN DERIVATIVE, A PREPARATION METHOD THEROF AND A PH RESPONSIVE CONJUGATE OF THE CYCLODEXTRIN DERIVATIVE AND A DRUG</title><author>SONG, YOUNG JUN ; PARK, EU DDEUM ; KANG, SUN YOUNG ; PIAOYINGLAN ; KIM, SUK WHA ; LEE, YAN ; CHOI, JAE HOON ; KIM, YOUNG EUN ; HUR, WOO JUNE ; CHOI, TAE HYUN ; MIN, HYE JEONG ; CHOI, LA MEE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR101622851BB13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>POLYSACCHARIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>SONG, YOUNG JUN</creatorcontrib><creatorcontrib>PARK, EU DDEUM</creatorcontrib><creatorcontrib>KANG, SUN YOUNG</creatorcontrib><creatorcontrib>PIAOYINGLAN</creatorcontrib><creatorcontrib>KIM, SUK WHA</creatorcontrib><creatorcontrib>LEE, YAN</creatorcontrib><creatorcontrib>CHOI, JAE HOON</creatorcontrib><creatorcontrib>KIM, YOUNG EUN</creatorcontrib><creatorcontrib>HUR, WOO JUNE</creatorcontrib><creatorcontrib>CHOI, TAE HYUN</creatorcontrib><creatorcontrib>MIN, HYE JEONG</creatorcontrib><creatorcontrib>CHOI, LA MEE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SONG, YOUNG JUN</au><au>PARK, EU DDEUM</au><au>KANG, SUN YOUNG</au><au>PIAOYINGLAN</au><au>KIM, SUK WHA</au><au>LEE, YAN</au><au>CHOI, JAE HOON</au><au>KIM, YOUNG EUN</au><au>HUR, WOO JUNE</au><au>CHOI, TAE HYUN</au><au>MIN, HYE JEONG</au><au>CHOI, LA MEE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PH RESPONSIVE CYCLODEXTRIN DERIVATIVE, A PREPARATION METHOD THEROF AND A PH RESPONSIVE CONJUGATE OF THE CYCLODEXTRIN DERIVATIVE AND A DRUG</title><date>2016-05-20</date><risdate>2016</risdate><abstract>The present invention relates to a pH-responsive cyclodextrin derivative, a preparation method thereof, and a pH-responsive conjugate of the pH-responsive cyclodextrin derivative and a drug, and more specifically, to a cyclodextrin derivative having a novel structure, a preparation method thereof, and a pH-responsive conjugate of the pH-responsive cyclodextrin derivative and a drug. The cyclodextrin derivative has a novel structure formed by a covalent bond between a maleic anhydride derivative and a cyclodextrin or a cyclodextrin derivative, in which a residue of the maleic anhydride derivative bonds to a primary hydroxyl group of cyclodextrin or a terminal functional group, such as NH_2, N_3, or amino acid, of a cyclodextrin derivative to produce a pH-responsive cyclodextrin derivative.
본 발명은 pH 응답성 사이클로덱스트린 유도체, 이의 제조방법 및 상기 사이클로덱스트린 유도체와 약물의 pH 응답성 결합체에 관한 것으로, 더욱 상세하게는 사이클로덱스트린 또는 이의 유도체와 말레산 무수물 유도체의 공유 결합에 의해 형성된 새로운 구조의 사이클로덱스트린 유도체로서, 사이클로덱스트린의 일차 히드록실기 또는 사이클로덱스트린 유도체의 NH, N또는 아미노산과 같은 말단 작용기에 말레산 무수물 유도체 잔기가 결합되어 형성되는 pH 응답성 사이클로덱스트린 유도체, 이의 제조방법 및 상기 사이클로덱스트린 유도체와 약물의 pH 응답성 결합체에 관한 것이다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | A PH RESPONSIVE CYCLODEXTRIN DERIVATIVE, A PREPARATION METHOD THEROF AND A PH RESPONSIVE CONJUGATE OF THE CYCLODEXTRIN DERIVATIVE AND A DRUG |
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