PRODUCTIONPROCESSOFS-PHENYL-L-CYSTEINE
PURPOSE: A process for producing S-phenyl-1-cysteine is provided to obtain S-phenyl-1-cysteine useful as an intermediate of pharmaceuticals and agricultural compounds with a higher purity and a greater yield. CONSTITUTION: The process for producing S-phenyl-L-cysteine comprises the steps of: (a) adj...
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creator | FUKUHARA, NOBUHIRO FUKUTA, KAZUHIRO |
description | PURPOSE: A process for producing S-phenyl-1-cysteine is provided to obtain S-phenyl-1-cysteine useful as an intermediate of pharmaceuticals and agricultural compounds with a higher purity and a greater yield. CONSTITUTION: The process for producing S-phenyl-L-cysteine comprises the steps of: (a) adjusting the pH of an enzymatic reaction mixture containing crystals of S-phenyl-L-cysteine to an acidic level, so that the crystals of S-phenyl-L-cysteine precipitated in the reaction mixture are dissolved; (b) adding activated carbon to the reaction mixture and then maintaining the resultant reaction mixture while aerating with an oxygen-containing gas, whereby a solid matter and unreacted thiophenol are adsorbed on the activated carbon and unreacted thiophenol not adsorbed on the activated carbon is insolubilized; (c) removing the activated carbon and insolubilized matter from the reaction mixture to obtain an S-phenyl-L-cysteine solution; and (d) adding an alkali to the S-phenyl-L-cysteine solution to precipitate crystals of S-phenyl-L-cysteine, and then recovering the crystals of S-phenyl-L-cysteine. |
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CONSTITUTION: The process for producing S-phenyl-L-cysteine comprises the steps of: (a) adjusting the pH of an enzymatic reaction mixture containing crystals of S-phenyl-L-cysteine to an acidic level, so that the crystals of S-phenyl-L-cysteine precipitated in the reaction mixture are dissolved; (b) adding activated carbon to the reaction mixture and then maintaining the resultant reaction mixture while aerating with an oxygen-containing gas, whereby a solid matter and unreacted thiophenol are adsorbed on the activated carbon and unreacted thiophenol not adsorbed on the activated carbon is insolubilized; (c) removing the activated carbon and insolubilized matter from the reaction mixture to obtain an S-phenyl-L-cysteine solution; and (d) adding an alkali to the S-phenyl-L-cysteine solution to precipitate crystals of S-phenyl-L-cysteine, and then recovering the crystals of S-phenyl-L-cysteine.</description><edition>7</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000315&DB=EPODOC&CC=KR&NR=100250416B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000315&DB=EPODOC&CC=KR&NR=100250416B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FUKUHARA, NOBUHIRO</creatorcontrib><creatorcontrib>FUKUTA, KAZUHIRO</creatorcontrib><title>PRODUCTIONPROCESSOFS-PHENYL-L-CYSTEINE</title><description>PURPOSE: A process for producing S-phenyl-1-cysteine is provided to obtain S-phenyl-1-cysteine useful as an intermediate of pharmaceuticals and agricultural compounds with a higher purity and a greater yield. CONSTITUTION: The process for producing S-phenyl-L-cysteine comprises the steps of: (a) adjusting the pH of an enzymatic reaction mixture containing crystals of S-phenyl-L-cysteine to an acidic level, so that the crystals of S-phenyl-L-cysteine precipitated in the reaction mixture are dissolved; (b) adding activated carbon to the reaction mixture and then maintaining the resultant reaction mixture while aerating with an oxygen-containing gas, whereby a solid matter and unreacted thiophenol are adsorbed on the activated carbon and unreacted thiophenol not adsorbed on the activated carbon is insolubilized; (c) removing the activated carbon and insolubilized matter from the reaction mixture to obtain an S-phenyl-L-cysteine solution; and (d) adding an alkali to the S-phenyl-L-cysteine solution to precipitate crystals of S-phenyl-L-cysteine, and then recovering the crystals of S-phenyl-L-cysteine.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFALCPJ3CXUO8fT3A7KcXYOD_d2CdQM8XP0ifXR9dJ0jg0NcPf1ceRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJvHeQoYGBkamBiaGZk5OhMXGqAJWaJQw</recordid><startdate>20000315</startdate><enddate>20000315</enddate><creator>FUKUHARA, NOBUHIRO</creator><creator>FUKUTA, KAZUHIRO</creator><scope>EVB</scope></search><sort><creationdate>20000315</creationdate><title>PRODUCTIONPROCESSOFS-PHENYL-L-CYSTEINE</title><author>FUKUHARA, NOBUHIRO ; FUKUTA, KAZUHIRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR100250416BB13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2000</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>FUKUHARA, NOBUHIRO</creatorcontrib><creatorcontrib>FUKUTA, KAZUHIRO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FUKUHARA, NOBUHIRO</au><au>FUKUTA, KAZUHIRO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PRODUCTIONPROCESSOFS-PHENYL-L-CYSTEINE</title><date>2000-03-15</date><risdate>2000</risdate><abstract>PURPOSE: A process for producing S-phenyl-1-cysteine is provided to obtain S-phenyl-1-cysteine useful as an intermediate of pharmaceuticals and agricultural compounds with a higher purity and a greater yield. CONSTITUTION: The process for producing S-phenyl-L-cysteine comprises the steps of: (a) adjusting the pH of an enzymatic reaction mixture containing crystals of S-phenyl-L-cysteine to an acidic level, so that the crystals of S-phenyl-L-cysteine precipitated in the reaction mixture are dissolved; (b) adding activated carbon to the reaction mixture and then maintaining the resultant reaction mixture while aerating with an oxygen-containing gas, whereby a solid matter and unreacted thiophenol are adsorbed on the activated carbon and unreacted thiophenol not adsorbed on the activated carbon is insolubilized; (c) removing the activated carbon and insolubilized matter from the reaction mixture to obtain an S-phenyl-L-cysteine solution; and (d) adding an alkali to the S-phenyl-L-cysteine solution to precipitate crystals of S-phenyl-L-cysteine, and then recovering the crystals of S-phenyl-L-cysteine.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE |
title | PRODUCTIONPROCESSOFS-PHENYL-L-CYSTEINE |
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