METHOD OF PREPARING 3-AMINO-1-HYDROXYPROPANE-1,1-DIPHOSPHONIC ACID

A preparation of 3-amino-1-hydroxypropane-1,1-diphosphonic acid includes the steps of: mixing N-alkoxycarbonyl- beta -alanine, phosphorous chloride and phosphorous acid in the ratio of 1:1:1 DIFFERENCE 1:3:3 in a reaction solvent, xylene at 70 DEG -140 DEG C.; hydrolyzing; and obtaining 3-amino-1-hy...

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Hauptverfasser:	JEONG, YEONG-HOON, LEE, GI-YEONG, KIM, YONG-HYEON, HAM, WON-HOON, OH, CHANG-YOUNG
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	A preparation of 3-amino-1-hydroxypropane-1,1-diphosphonic acid includes the steps of: mixing N-alkoxycarbonyl- beta -alanine, phosphorous chloride and phosphorous acid in the ratio of 1:1:1 DIFFERENCE 1:3:3 in a reaction solvent, xylene at 70 DEG -140 DEG C.; hydrolyzing; and obtaining 3-amino-1-hydroxypropane-1,1-diphosphonic acid as a product, thus decreasing the production of unidentified by-products and giving and low production cost by using xylene instead of chlorobenzene as a reaction solvent.