SYNTHETIC PEPTIDE AND ANTIBODY THERETO
The synthetic peptides have amino-acid sequences which correspond in whole or in part to the amino-acid sequence of prothrombin and are antigenic, and they are used for immunising an animal and for purifying specific antibodies, and the antibodies against these peptides are used to determine the F2/...
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| creator | BUERUNAA SHIYUTEYUUBAA HERUMAN PERUTSUAA |
| description | The synthetic peptides have amino-acid sequences which correspond in whole or in part to the amino-acid sequence of prothrombin and are antigenic, and they are used for immunising an animal and for purifying specific antibodies, and the antibodies against these peptides are used to determine the F2/F1+2 fragments. Hitherto used for the determination of the contents of the F2/F1+2 fragments have been antibodies induced by immunisation with natural, highly purified prothrombin F2/F1+2 fragments. The isolation of these prothrombin fragments is elaborate and costly, and the antibodies raised therewith show cross-reactions with intact prothrombin. Used for the immunisation according to the invention are synthetic peptides which have amino-acid sequences which correspond in whole or in part to the amino-acid sequence of prothrombin and are antigenic. The resulting antibodies react specifically with the antigen to be used for immunisation; if the peptides contain the carboxy-terminal amino-acid sequence of the F2/F1+2 fragments resulting after cleavage of the prothrombin molecule with factor Xa, the antibodies which are raised react specifically with the F2/F1+2 fragments but not with intact native prothrombin so that it is possible to obtain information about the degree of activation of prothrombin. |
| format | Patent |
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Hitherto used for the determination of the contents of the F2/F1+2 fragments have been antibodies induced by immunisation with natural, highly purified prothrombin F2/F1+2 fragments. The isolation of these prothrombin fragments is elaborate and costly, and the antibodies raised therewith show cross-reactions with intact prothrombin. Used for the immunisation according to the invention are synthetic peptides which have amino-acid sequences which correspond in whole or in part to the amino-acid sequence of prothrombin and are antigenic. The resulting antibodies react specifically with the antigen to be used for immunisation; if the peptides contain the carboxy-terminal amino-acid sequence of the F2/F1+2 fragments resulting after cleavage of the prothrombin molecule with factor Xa, the antibodies which are raised react specifically with the F2/F1+2 fragments but not with intact native prothrombin so that it is possible to obtain information about the degree of activation of prothrombin.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890315&DB=EPODOC&CC=JP&NR=S6470498A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890315&DB=EPODOC&CC=JP&NR=S6470498A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BUERUNAA SHIYUTEYUUBAA</creatorcontrib><creatorcontrib>HERUMAN PERUTSUAA</creatorcontrib><title>SYNTHETIC PEPTIDE AND ANTIBODY THERETO</title><description>The synthetic peptides have amino-acid sequences which correspond in whole or in part to the amino-acid sequence of prothrombin and are antigenic, and they are used for immunising an animal and for purifying specific antibodies, and the antibodies against these peptides are used to determine the F2/F1+2 fragments. Hitherto used for the determination of the contents of the F2/F1+2 fragments have been antibodies induced by immunisation with natural, highly purified prothrombin F2/F1+2 fragments. The isolation of these prothrombin fragments is elaborate and costly, and the antibodies raised therewith show cross-reactions with intact prothrombin. Used for the immunisation according to the invention are synthetic peptides which have amino-acid sequences which correspond in whole or in part to the amino-acid sequence of prothrombin and are antigenic. The resulting antibodies react specifically with the antigen to be used for immunisation; if the peptides contain the carboxy-terminal amino-acid sequence of the F2/F1+2 fragments resulting after cleavage of the prothrombin molecule with factor Xa, the antibodies which are raised react specifically with the F2/F1+2 fragments but not with intact native prothrombin so that it is possible to obtain information about the degree of activation of prothrombin.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFALjvQL8XAN8XRWCHANCPF0cVVw9HMB4hBPJ3-XSAWgXJBriD8PA2taYk5xKi-U5mZQcHMNcfbQTS3Ij08tLkhMTs1LLYn3Cgg2MzE3MLG0cDQmQgkAkikjnQ</recordid><startdate>19890315</startdate><enddate>19890315</enddate><creator>BUERUNAA SHIYUTEYUUBAA</creator><creator>HERUMAN PERUTSUAA</creator><scope>EVB</scope></search><sort><creationdate>19890315</creationdate><title>SYNTHETIC PEPTIDE AND ANTIBODY THERETO</title><author>BUERUNAA SHIYUTEYUUBAA ; HERUMAN PERUTSUAA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS6470498A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1989</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BUERUNAA SHIYUTEYUUBAA</creatorcontrib><creatorcontrib>HERUMAN PERUTSUAA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BUERUNAA SHIYUTEYUUBAA</au><au>HERUMAN PERUTSUAA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SYNTHETIC PEPTIDE AND ANTIBODY THERETO</title><date>1989-03-15</date><risdate>1989</risdate><abstract>The synthetic peptides have amino-acid sequences which correspond in whole or in part to the amino-acid sequence of prothrombin and are antigenic, and they are used for immunising an animal and for purifying specific antibodies, and the antibodies against these peptides are used to determine the F2/F1+2 fragments. Hitherto used for the determination of the contents of the F2/F1+2 fragments have been antibodies induced by immunisation with natural, highly purified prothrombin F2/F1+2 fragments. The isolation of these prothrombin fragments is elaborate and costly, and the antibodies raised therewith show cross-reactions with intact prothrombin. Used for the immunisation according to the invention are synthetic peptides which have amino-acid sequences which correspond in whole or in part to the amino-acid sequence of prothrombin and are antigenic. The resulting antibodies react specifically with the antigen to be used for immunisation; if the peptides contain the carboxy-terminal amino-acid sequence of the F2/F1+2 fragments resulting after cleavage of the prothrombin molecule with factor Xa, the antibodies which are raised react specifically with the F2/F1+2 fragments but not with intact native prothrombin so that it is possible to obtain information about the degree of activation of prothrombin.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | SYNTHETIC PEPTIDE AND ANTIBODY THERETO |
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