BETA-LACTAM INTERMEDIATE

NEW MATERIAL:Optically active 4-alkoxyazetidin-2-one compound of formula I (R is hydroxyl-protecting group; R is H or amino-protecting group; R is 1-4C aliphatic hydrocarbon group). EXAMPLE:(3R,4R,5R)-3-[1-(t-butyldimethylsiloxy)ethyl-4-methoxy-azetidi n-2-one. USE:A synthetic intermediate for penem...

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Hauptverfasser:	WATANABE KIYOSHI, SHIMAZAKI MASAMI, OHASHI TAKEHISA, FUKAE MASABUMI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:Optically active 4-alkoxyazetidin-2-one compound of formula I (R is hydroxyl-protecting group; R is H or amino-protecting group; R is 1-4C aliphatic hydrocarbon group). EXAMPLE:(3R,4R,5R)-3-[1-(t-butyldimethylsiloxy)ethyl-4-methoxy-azetidi n-2-one. USE:A synthetic intermediate for penem-type beta-lactam antibiotic substance. The compound is characterized by the presence of alkoxy group at 4-site. PREPARATION:The compound of formula I can be produced by reacting 3-[1-(t- butyldimethylsiloxy)ethyl]-4-acetoxyazetidin-2-one of formula II with sodium alcoholate as a base in an alkanol.