JPS6216942B
The compounds of general formula I, wherein R to R , m and n have the meaning given in Claim 1, are valuable medicaments which are suitable for the treatment of diabetic angiopathy. They are prepared by either reacting an amidoxime of formula II with epichlorohydrin to give an epoxide of formula IV...
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| creator | SZENTIVANYI MATYAS NAGY PETER LITERATI VIRAG SANDOR SIMAY ANTAL FARAGO KATALIN KISS ILONA TAKACS KALMAN |
| description | The compounds of general formula I, wherein R to R , m and n have the meaning given in Claim 1, are valuable medicaments which are suitable for the treatment of diabetic angiopathy. They are prepared by either reacting an amidoxime of formula II with epichlorohydrin to give an epoxide of formula IV and then reacting the epoxide with an amine of formula III or by directly reacting the amidoxime of formula II with a 3-amino-2-hydroxy-1-halogenopropane of formula Va, wherein X represents halogen, or a 3-amino-1,2-epoxypropane of formula Vb. Compounds of formula I, wherein R denotes hydrogen, are also prepared by reacting an amidoxime of formula II with a 2-phenyl-5-halogenomethyloxazolidine of formula VI, wherein X represents halogen, after which the ring compound obtained, of formula VII, is cleaved hydrolytically. |
| format | Patent |
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They are prepared by either reacting an amidoxime of formula II with epichlorohydrin to give an epoxide of formula IV and then reacting the epoxide with an amine of formula III or by directly reacting the amidoxime of formula II with a 3-amino-2-hydroxy-1-halogenopropane of formula Va, wherein X represents halogen, or a 3-amino-1,2-epoxypropane of formula Vb. Compounds of formula I, wherein R denotes hydrogen, are also prepared by reacting an amidoxime of formula II with a 2-phenyl-5-halogenomethyloxazolidine of formula VI, wherein X represents halogen, after which the ring compound obtained, of formula VII, is cleaved hydrolytically.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1987</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870415&DB=EPODOC&CC=JP&NR=S6216942B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870415&DB=EPODOC&CC=JP&NR=S6216942B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SZENTIVANYI MATYAS</creatorcontrib><creatorcontrib>NAGY PETER LITERATI</creatorcontrib><creatorcontrib>VIRAG SANDOR</creatorcontrib><creatorcontrib>SIMAY ANTAL</creatorcontrib><creatorcontrib>FARAGO KATALIN</creatorcontrib><creatorcontrib>KISS ILONA</creatorcontrib><creatorcontrib>TAKACS KALMAN</creatorcontrib><title>JPS6216942B</title><description>The compounds of general formula I, wherein R to R , m and n have the meaning given in Claim 1, are valuable medicaments which are suitable for the treatment of diabetic angiopathy. They are prepared by either reacting an amidoxime of formula II with epichlorohydrin to give an epoxide of formula IV and then reacting the epoxide with an amine of formula III or by directly reacting the amidoxime of formula II with a 3-amino-2-hydroxy-1-halogenopropane of formula Va, wherein X represents halogen, or a 3-amino-1,2-epoxypropane of formula Vb. Compounds of formula I, wherein R denotes hydrogen, are also prepared by reacting an amidoxime of formula II with a 2-phenyl-5-halogenomethyloxazolidine of formula VI, wherein X represents halogen, after which the ring compound obtained, of formula VII, is cleaved hydrolytically.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1987</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOD2Cgg2MzI0szQxcuJhYE1LzClO5YXS3AxKbq4hzh66qQX58anFBYnJqXmpJfFIOpyMjIlSBACEfBxv</recordid><startdate>19870415</startdate><enddate>19870415</enddate><creator>SZENTIVANYI MATYAS</creator><creator>NAGY PETER LITERATI</creator><creator>VIRAG SANDOR</creator><creator>SIMAY ANTAL</creator><creator>FARAGO KATALIN</creator><creator>KISS ILONA</creator><creator>TAKACS KALMAN</creator><scope>EVB</scope></search><sort><creationdate>19870415</creationdate><title>JPS6216942B</title><author>SZENTIVANYI MATYAS ; NAGY PETER LITERATI ; VIRAG SANDOR ; SIMAY ANTAL ; FARAGO KATALIN ; KISS ILONA ; TAKACS KALMAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS6216942BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1987</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SZENTIVANYI MATYAS</creatorcontrib><creatorcontrib>NAGY PETER LITERATI</creatorcontrib><creatorcontrib>VIRAG SANDOR</creatorcontrib><creatorcontrib>SIMAY ANTAL</creatorcontrib><creatorcontrib>FARAGO KATALIN</creatorcontrib><creatorcontrib>KISS ILONA</creatorcontrib><creatorcontrib>TAKACS KALMAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SZENTIVANYI MATYAS</au><au>NAGY PETER LITERATI</au><au>VIRAG SANDOR</au><au>SIMAY ANTAL</au><au>FARAGO KATALIN</au><au>KISS ILONA</au><au>TAKACS KALMAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>JPS6216942B</title><date>1987-04-15</date><risdate>1987</risdate><abstract>The compounds of general formula I, wherein R to R , m and n have the meaning given in Claim 1, are valuable medicaments which are suitable for the treatment of diabetic angiopathy. They are prepared by either reacting an amidoxime of formula II with epichlorohydrin to give an epoxide of formula IV and then reacting the epoxide with an amine of formula III or by directly reacting the amidoxime of formula II with a 3-amino-2-hydroxy-1-halogenopropane of formula Va, wherein X represents halogen, or a 3-amino-1,2-epoxypropane of formula Vb. Compounds of formula I, wherein R denotes hydrogen, are also prepared by reacting an amidoxime of formula II with a 2-phenyl-5-halogenomethyloxazolidine of formula VI, wherein X represents halogen, after which the ring compound obtained, of formula VII, is cleaved hydrolytically.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | JPS6216942B |
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