AZACYCLOALKANE DERIVATIVE
NEW MATERIAL:An azacycloalkane derivative expressed by formula I (R is alkyl; m is 2-4; n is 2-15). EXAMPLE:1-(6-Pentyloxycyclohexyl)azacyclopentan-2-one. USE:Capable of being blended with an absorption accelerator useful for the pharmaceutical industry or cosmetics, e.g. quasi-drugs, etc., and agri...
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| creator | SHIMOZONO YUJI TSUJI MASAYOSHI YATANI TERUMI INOUE TOSHITAKA KATSUKI MASUMI NAKAJIMA MIKIO SAIDA MASARU SAKAI MICHIYORI |
| description | NEW MATERIAL:An azacycloalkane derivative expressed by formula I (R is alkyl; m is 2-4; n is 2-15). EXAMPLE:1-(6-Pentyloxycyclohexyl)azacyclopentan-2-one. USE:Capable of being blended with an absorption accelerator useful for the pharmaceutical industry or cosmetics, e.g. quasi-drugs, etc., and agricultural chemicals, insecticides, etc., having improved enhancing action on penetrability and permeability of drugs into biomembranes, e.g. skin, mucosa, etc., and further individual antimicrobial action and high safety with very weak local irritancy to the biomembranes and systemic toxicity, etc. PREPARATION:For example, a compound expressed by formula IV is reacted in the presence of an alkali catalyst, etc., to form a compound expressed by formula II (M is alkali metal ion), which is then reacted with a compound expressed by formula V (X is halogen, mesyl, etc.) to afford a compound expressed by formula III. The resultant compound expressed by formula III is further reacted with an alcohol expressed by the formula R-OH in the presence of an alkali catalyst to give the aimed compound expressed by formula I. |
| format | Patent |
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EXAMPLE:1-(6-Pentyloxycyclohexyl)azacyclopentan-2-one. USE:Capable of being blended with an absorption accelerator useful for the pharmaceutical industry or cosmetics, e.g. quasi-drugs, etc., and agricultural chemicals, insecticides, etc., having improved enhancing action on penetrability and permeability of drugs into biomembranes, e.g. skin, mucosa, etc., and further individual antimicrobial action and high safety with very weak local irritancy to the biomembranes and systemic toxicity, etc. PREPARATION:For example, a compound expressed by formula IV is reacted in the presence of an alkali catalyst, etc., to form a compound expressed by formula II (M is alkali metal ion), which is then reacted with a compound expressed by formula V (X is halogen, mesyl, etc.) to afford a compound expressed by formula III. The resultant compound expressed by formula III is further reacted with an alcohol expressed by the formula R-OH in the presence of an alkali catalyst to give the aimed compound expressed by formula I.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1987</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870721&DB=EPODOC&CC=JP&NR=S62164662A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870721&DB=EPODOC&CC=JP&NR=S62164662A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHIMOZONO YUJI</creatorcontrib><creatorcontrib>TSUJI MASAYOSHI</creatorcontrib><creatorcontrib>YATANI TERUMI</creatorcontrib><creatorcontrib>INOUE TOSHITAKA</creatorcontrib><creatorcontrib>KATSUKI MASUMI</creatorcontrib><creatorcontrib>NAKAJIMA MIKIO</creatorcontrib><creatorcontrib>SAIDA MASARU</creatorcontrib><creatorcontrib>SAKAI MICHIYORI</creatorcontrib><title>AZACYCLOALKANE DERIVATIVE</title><description>NEW MATERIAL:An azacycloalkane derivative expressed by formula I (R is alkyl; m is 2-4; n is 2-15). EXAMPLE:1-(6-Pentyloxycyclohexyl)azacyclopentan-2-one. USE:Capable of being blended with an absorption accelerator useful for the pharmaceutical industry or cosmetics, e.g. quasi-drugs, etc., and agricultural chemicals, insecticides, etc., having improved enhancing action on penetrability and permeability of drugs into biomembranes, e.g. skin, mucosa, etc., and further individual antimicrobial action and high safety with very weak local irritancy to the biomembranes and systemic toxicity, etc. PREPARATION:For example, a compound expressed by formula IV is reacted in the presence of an alkali catalyst, etc., to form a compound expressed by formula II (M is alkali metal ion), which is then reacted with a compound expressed by formula V (X is halogen, mesyl, etc.) to afford a compound expressed by formula III. The resultant compound expressed by formula III is further reacted with an alcohol expressed by the formula R-OH in the presence of an alkali catalyst to give the aimed compound expressed by formula I.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1987</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJB0jHJ0jnT28Xf08Xb0c1VwcQ3yDHMM8Qxz5WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8V4BwWZGhmYmZmZGjsbEqAEAKCEgbw</recordid><startdate>19870721</startdate><enddate>19870721</enddate><creator>SHIMOZONO YUJI</creator><creator>TSUJI MASAYOSHI</creator><creator>YATANI TERUMI</creator><creator>INOUE TOSHITAKA</creator><creator>KATSUKI MASUMI</creator><creator>NAKAJIMA MIKIO</creator><creator>SAIDA MASARU</creator><creator>SAKAI MICHIYORI</creator><scope>EVB</scope></search><sort><creationdate>19870721</creationdate><title>AZACYCLOALKANE DERIVATIVE</title><author>SHIMOZONO YUJI ; TSUJI MASAYOSHI ; YATANI TERUMI ; INOUE TOSHITAKA ; KATSUKI MASUMI ; NAKAJIMA MIKIO ; SAIDA MASARU ; SAKAI MICHIYORI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS62164662A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1987</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIMOZONO YUJI</creatorcontrib><creatorcontrib>TSUJI MASAYOSHI</creatorcontrib><creatorcontrib>YATANI TERUMI</creatorcontrib><creatorcontrib>INOUE TOSHITAKA</creatorcontrib><creatorcontrib>KATSUKI MASUMI</creatorcontrib><creatorcontrib>NAKAJIMA MIKIO</creatorcontrib><creatorcontrib>SAIDA MASARU</creatorcontrib><creatorcontrib>SAKAI MICHIYORI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHIMOZONO YUJI</au><au>TSUJI MASAYOSHI</au><au>YATANI TERUMI</au><au>INOUE TOSHITAKA</au><au>KATSUKI MASUMI</au><au>NAKAJIMA MIKIO</au><au>SAIDA MASARU</au><au>SAKAI MICHIYORI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AZACYCLOALKANE DERIVATIVE</title><date>1987-07-21</date><risdate>1987</risdate><abstract>NEW MATERIAL:An azacycloalkane derivative expressed by formula I (R is alkyl; m is 2-4; n is 2-15). EXAMPLE:1-(6-Pentyloxycyclohexyl)azacyclopentan-2-one. USE:Capable of being blended with an absorption accelerator useful for the pharmaceutical industry or cosmetics, e.g. quasi-drugs, etc., and agricultural chemicals, insecticides, etc., having improved enhancing action on penetrability and permeability of drugs into biomembranes, e.g. skin, mucosa, etc., and further individual antimicrobial action and high safety with very weak local irritancy to the biomembranes and systemic toxicity, etc. PREPARATION:For example, a compound expressed by formula IV is reacted in the presence of an alkali catalyst, etc., to form a compound expressed by formula II (M is alkali metal ion), which is then reacted with a compound expressed by formula V (X is halogen, mesyl, etc.) to afford a compound expressed by formula III. The resultant compound expressed by formula III is further reacted with an alcohol expressed by the formula R-OH in the presence of an alkali catalyst to give the aimed compound expressed by formula I.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | AZACYCLOALKANE DERIVATIVE |
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